“…If a sample contains a large number of substances, representing a wide range of distribution ratios, it is advantageous to consider the use of programmed changes in temperature (10), flow ( tration of a reagent (13,14) in order to minimize the time required. However, one should not overlook the fact that there is an interplay, for example, between flow rate of the carrier and rate of temperature change which can, in turn, be optimized.…”