THEORETICAL VALIDATION OF MEDICINAL PROPERTIES OF Curcuma longa Linn

Abstract

Molecular property and bio-activity scores of seven curcuminoids derivative of Curcuma longa Linn present in Curcuma longa Linn were predicted using molinspiration software. For all the essential oil compounds, miLog P values were observed to be 5 this shows these compounds were not easily permeable across the cell membrane. TPSA in the assortment of 0.00 -66.76 (well below 160Å2) and n violations= 1 or 0, molecular mass < 5 [10], N0 of hydrogen bond donors ≤ 5 (the sum of OHs and NHs), No of hydrogen bond acceptor ≤ 10 (The sum of Os and Ns) were pragmatic for these compounds. This designates that these compounds were found to obey Lipinski's rule and can simply bind to the receptor and further used for the calculation of bioactivity score. The bioactivity score calculated by the activity score of GPCR ligand, ion channel modulator, nuclear receptor ligand, kinase inhibitor, protease inhibitor and enzyme inhibitor.

In Silico, to Determine the Active Compounds of Black Tea and Turmeric in Increasing the Activity of the Enzyme Sod

“…The test ligand is an active compound of turmeric rhizome which belongs to the curcuminoid and terpenoid groups. Suryawanshi & Kulkarni, (2020) stated that seven curcuminoid compounds complied with Lipinski. Dongare et al (2019) stated that as many as ten terpenoid compounds complied with Lipinski.…”