Theoretical study of multicomponent continuous countercurrent chromatography based on connected 4-zone units

Keßler, L. C.; Seidel‐Morgenstern, A.

doi:10.1016/j.chroma.2006.05.012

Cited by 38 publications

(20 citation statements)

References 41 publications

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“…The common approach for such multicomponent process is the simple application of SMB cascades [73,[125][126][127][128] or the use of internal loops with enrichment stages in sequential (eight sections) SMB units [129]. Nonetheless, there are also nonconventional SMB operation solutions that allow the achievement of more than two high-purity products in the same unit, as the one commercialized by the Japan Organo Co.…”

Section: Multicomponent Separationsmentioning

confidence: 98%

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Gomes

Rodrigues

2011

Chem Eng & Technol

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This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE® unit is addressed to better exemplify a state-ofthe-art SMB lab-scale process development and demonstration.

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Section: Multicomponent Separationsmentioning

confidence: 98%

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Gomes

Rodrigues

2011

Chem Eng & Technol

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“…12, right) simulated for the case of linear isotherms. Due the fact that the combination of closed loops and complete internal recycling of one outlet stream (here the effluent between zones V and VI) does not allow all mass balance constraints to be met [84], an additional solvent reduction step is implemented (see section D above), thus rendering complete separation possible [88]. Such a continuous concentration step offers the additional advantage of increasing product concentrations in the streams leaving the lower subunit.…”

Section: G Ternary and Pseudo-ternary Separationsmentioning

confidence: 99%

“…Recently, a fivezone open-loop process was suggested which can completely resolve a ternary mixture [46]. Several schemes offering the possibility to separate quaternary mixtures were proposed in [87,88].…”

Section: G Ternary and Pseudo-ternary Separationsmentioning

confidence: 99%

New Developments in Simulated Moving Bed Chromatography

2008

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Chromatographic separation processes are widely used to isolate and purify value added products. Most frequently, such separation processes are performed exploiting the principles of injecting samples of the feed mixture in a repetitive periodic manner and collecting the target products batchwise. In the early 1960s, an alternative operation principle based on using several columns connected in series and exploiting a continuous countercurrent movement between the mobile and stationary phases initiated significant improvements in performing specific separation processes in the petrochemical and sugar industries. In the last decade, the so-called simulated moving bed (SMB) chromatography has rapidly entered the pharmaceutical industry. In particular enantioseparations using chiral stationary phases have become a strong driving force to develop more sophisticated concepts of continuous chromatography. Currently, the growing interest in efficient methods for the downstream processing of biomolecules enhances interest in SMB processes. This paper gives a brief overview of the new suggestions and trends. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [accessed July 4, 2008

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“…The very name of the technique has been a matter of controversy as in most cases there is absolutely no countercurrent circulation of phases: Only one of the liquids flows while the other one is stationary. Moreover, a significant number of reports use countercurrent chromatography when refer-ring to SMB [35,36]. Unfortunately, after almost 60 years from its invention, given the broad acceptance of the name and that of the acronym CCC by the users of the technique, it does not seem appropriate to change it.…”

Section: Instrumentation and Solvent Systemsmentioning

confidence: 99%

Countercurrent Chromatography, Scope and Perspectives: Application to Chirotechnology

Minguillón

2011

Chem Eng & Technol

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Countercurrent chromatography (CCC) is a liquid-liquid separation technique particularly adapted to preparative separations. In spite of the broad range of applications possible, CCC is mainly applied to the purification of natural products from complex mixtures, field in which some of the characteristics of CCC make it advantageous over other more common chromatographic modalities. Nevertheless, CCC has much to offer in biotechnological purification and enantioseparation. The general characteristics, advantages and drawbacks of CCC, together with its application in dieverse contexts, in paricular enantioseparations, are discussed. IntroductionThe purity requirements demanded in the production of biopharmaceuticals and fine chemicals for the manufacture of active pharmaceutical ingredients (API) have led to a renewed and widespread interest in preparative chromatography [1,2]. The theoretical understanding of the main factors controlling the process, and therefore the possibility to predict its outcome [3,4], has promoted a change in the industrial mentality from the previous reticence. After the wide realization of the cost effectiveness of this purification approach, chromatography has recently become the preferred method for rapidly accessing products of high added value, such as enantiomers [5,6] and biopharmaceuticals [7,8]. Simulated moving bed (SMB), a continuous liquid-solid technique that permits an improved use of the expensive stationary phase, has played a significant role in bringing chromatography closer to the industrial users. Nevertheless, one of the main disadvantages of SMB is the considerable investment required in equipment.Among the possible alternatives easily adapted to be run in continuous mode, countercurrent chromatography (CCC), a liquid-liquid technique in which the separation of components in a mixture is based on their different partitioning into two immiscible liquids [9][10][11][12], can be considered. Although CCC was described in the 1960s [13] and therefore cannot be contemplated as a new technique, in the recent years the increasing development and adoption of preparative chromatography have had a knock-on effect on CCC. As a consequence, the number of publications and studies dealing with CCC has considerably increased. The particular selectivity, high loading capacity and low solvent demand per amount of substrate processed are the reasons that justify the interest in CCC. CCC versus HPLC: Advantages and DrawbacksThe most characteristic feature of CCC, the absence of a solid support, greatly determines its properties, advantages and limitations. Two immiscible liquids, acting as stationary and mobile phase, respectively, are involved in the chromatographic process. The usual way to maintain one of the liquids stationary while the other is passing through requires the establishment of a centrifugal force in the instrument. The difference in density of the two liquids involved completes the job. Nevertheless, to handle liquids in such a way demands moving parts, rotors, gears...

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Theoretical study of multicomponent continuous countercurrent chromatography based on connected 4-zone units

Cited by 38 publications

References 41 publications

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

New Developments in Simulated Moving Bed Chromatography

Countercurrent Chromatography, Scope and Perspectives: Application to Chirotechnology

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