Theoretical model of thalassemic erythrocyte shape transformation

Pawłowski, Piotr H.; Burzyńska, Beata; Zielenkiewicz, Piotr

doi:10.1016/j.jtbi.2008.06.029

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The previous study of Bilto and Assaf 36 showed that there is an increase in the amount of iron and ferritin in the serum of Iraqi thalassemia patients, accumulation of iron leads to increase absorption of iron in the intestine, the main cause of oxidative damage to organelles of the cell and erythrocytes in thalassemia patients is due to increase in iron overload 37 . And that damage is due to susceptible of thalassemia patients' erythrocytes to auto-oxidant in comparison to the control group 38 .This susceptible is due to high content of polyunsaturated fatty acid in the membrane of erythrocytes and the high concentration of hemoglobin and oxygen in cell which is the main source of ROC 39 , and is also because the inability of erythrocytes to synthesis damage components of cells 40 .…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Hematological Study with the Appreciation of some Immunological Parameters in Thalassemia Patients at Kerbala Province

Al-Dedah¹,

Al-Wazni²,

Abbas³

et al. 2018

J Pure Appl Microbiol

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Thalassemia is a genetic disorder occurs as a result of the imbalance in the construction of haemoglobin chains cause haemolytic anaemia. This study was aimed to evaluate the serum level of immunological parameters (Transforming growth factor beta1, Interleukin-23) and hematological parameters in patients with alpha and beta thalassemia at Kerbala province. And was conducted at Kerbala Children's Hospital / Thalassemia Department / Kerbala Governorate during the period from November 2017 to May 2018. Seventy patients involved 48 beta thalassemia patients and 22 alpha thalassemia patients with age ranged 10-20 years old and ten matched healthy controls were enrolled in the study. Result exposed non-significant increase (p>0.05) in IL-23 and TGF-β in thalassemia patients compared with control group. In β-thalassemia patients the results of the current study indicated that non-significant positive correlation between IL-23 with WBC, there was non-significant positive correlation between TGF-β1 with WBC and PLT. As for β-thalassemia patients the present study showed non-significant positive correlation between IL-23 with Hb and WBC, and there was non-significant positive correlation between TGF-β1 with WBC. The study showed changes in the immunological parameters in patients with thalassemia of both types, as the serum level of both IL-23 and TGF-β1 were raised in addition to changes in hematological and Biochemical parameters.

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Section: Discussionmentioning

confidence: 99%

Biochemical and Hematological Study with the Appreciation of some Immunological Parameters in Thalassemia Patients at Kerbala Province

Al-Dedah¹,

Al-Wazni²,

Abbas³

et al. 2018

J Pure Appl Microbiol

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“…Finally, this method could have an implication for determination of abnormal morphology and irregular shape of RBCs in sickle-cell diseases 36 such as Thalassemia. 37,38…”

Section: Resultsmentioning

confidence: 99%

An innovative shape equation to quantify the morphological characteristics of parasitized red blood cells by Plasmodium falciparum and Plasmodium vivax

Karimi

Navidbakhsh

Haghi

et al. 2013

Proc Inst Mech Eng H

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The morphology of red blood cells is affected significantly during maturation of malaria parasites, Plasmodium falciparum and Plasmodium vivax. A novel shape equation is presented that defines shape of parasitized red blood cells by P. falciparum (Pf-red blood cells) and P. vivax (Pv-red blood cells) at four stages of infection. The Giemsa-stained thin blood films are prepared using blood samples collected from healthy donors, patients having P. falciparum and P. vivax malaria. The diameter and thickness of healthy red blood cells plus Pf-red blood cells and Pv-red blood cells at each stage of infection are measured from their optical images using Olysia and Scanning Probe Image Processor softwares, respectively. Using diameters and thicknesses of parasitized red blood cells, a shape equation is fitted and relative two-dimensional shapes are plotted using MATHEMATICA. The shape of Pf-red blood cell drastically changes at ring stage as its thickness increases by 82%, while Pv-red blood cell remains biconcave (30% increase in thickness). By trophozoite and subsequent schizont stage, the Pf-red blood cell entirely loses its biconcave shape and becomes near spherical (diameter and thickness of ~8 µm). The Pv-red blood cell remains biconcave throughout the parasite development even though its volume increases. These results could have practical use for faster diagnosis, prediction, and treatment of human malaria and sickle-cell diseases.

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Effect of Oxidative Stress on Membrane Proteins in Thalassemia and Iron Deficiency Anemia

Ariyurek

Aksoy

2011

Indian J Pediatr

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Theoretical model of thalassemic erythrocyte shape transformation

Cited by 3 publications

References 15 publications

Biochemical and Hematological Study with the Appreciation of some Immunological Parameters in Thalassemia Patients at Kerbala Province

Biochemical and Hematological Study with the Appreciation of some Immunological Parameters in Thalassemia Patients at Kerbala Province

An innovative shape equation to quantify the morphological characteristics of parasitized red blood cells by Plasmodium falciparum and Plasmodium vivax

Effect of Oxidative Stress on Membrane Proteins in Thalassemia and Iron Deficiency Anemia

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