Theoretical model of reticulocyte to erythrocyte shape transformation

Mechanokinetic model of cell membrane: Theoretical analysis of plasmalemma homeostasis, growth and division

“…This may not be a good idea in studies of growing, remodeling or stretched cells, exchanging their membrane material with the cell interior (Wolfe and Steponkus, 1983). Our previous work (Pawlowski et al, 2006) shows that an opposite assumption of an openmembrane system may be valuable for the description of changes in cell shape during its maturation. In developing this open-system concept, we propose a mechanokinetics model of cell membrane relating its mechanical properties to the kinetics of membrane budding and endo-exo traffic, both being tension dependent.…”

Theoretical model of thalassemic erythrocyte shape transformation

“…Computer simulations of thalassemic cell shape transformation were performed according to the standard model of reticulocyte to erythrocyte shape transformation (Pawlowski et al, 2006), modified in selected parameters. Briefly, starting with the initial sphere (reticulocyte) of 150 (mm 3 ) volume, the unknown R a -azimuthal radius, R t -tangential radius, and H 1 , H 2 -cell ''poles'' distances from the ''equator'' plane, were randomly and simultaneously changed 1000 times in 1% intervals around the actual values, at fixed other parameters of the model, to find the maximal decrease in the free energy of the system.…”

“…To reach the goal, the recently proposed theoretical model of reticulocyte to erythrocyte shape transformation (Pawlowski et al, 2006) has been applied. Thus, by modifying its standard parameters, i.e., decreasing the minimal cell volume and increasing the magnitude of membrane leaflet tension and bending elasticity modulus, we could numerically simulate the evolution of reticulocyte shapes towards microcytes or small ovals.…”

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a b s t r a c tOur earlier model of reticulocyte shape transformation [Pawlowski, P.H., Burzynska, B., Zielenkiewicz, P., 2006. Theoretical model of reticulocyte to erythrocyte shape transformation.

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Visualization study of motion and deformation of red blood cells in a microchannel with straight, divergent and convergent sections

“…The former is a multi-protein complex formed by structural proteins. It interacts with the lipid bilayer and transmembrane proteins to provide the RBC with strength and plasticity [2]. The lipid bilayer is a thin membrane made of two layers of phospholipid molecules.…”