Theoretical evaluation of dispersed droplet radii in submicron oil-in-water emulsions

Silvestri, Shawn; Lostritto, Richard T.

doi:10.1016/0378-5173(89)90138-5

Cited by 8 publications

(2 citation statements)

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“…The nanoemulsions were formed using high surfactant concentration (1:1 surfactant to oil phase) and low shear rates (400 rpm) (low energy emulsification method) (Morais et al, 2006), indicating that the oil droplets are surrounded by a multi-lamellar surfactant film (Silvestri and Lostritto, 1989). The film arrangement of CremophorRH40 1 and Span80 1 in water and canola oil solutions, based on surface/interfacial elasticity and viscosity measurements, has been previously reported by our group (Morais et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

In vitro release testing methods for vitamin E nanoemulsions

Morais

Burgess

2014

International Journal of Pharmaceutics

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Section: Discussionmentioning

confidence: 99%

In vitro release testing methods for vitamin E nanoemulsions

Morais

Burgess

2014

International Journal of Pharmaceutics

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“…Both freshly prepared and 1month-old emulsions had polydispersity values of approximately 1.04 (Table 1). Polydispersity values greater than 1.40 are considered to indicate polydispersity (21).…”

Section: Emulsion Stabilitymentioning

confidence: 99%

A novel in vitro release method for submicron-sized dispersed systems

1999

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Sink conditions are often violated when using conventional release methods for dispersed systems. A novel reverse dialysis bag method was designed to overcome this problem. Model drug transport rates from submicron emulsions obtained using the conventional diffusion cell method and this novel method were compared. In the side-by-side diffusion cell method, emulsions were placed in the donor chamber and surfactant/buffer solutions in the receiver chamber. In the novel dialysis bag method, emulsions were diluted infinitely in the donor phase and surfactant/buffer solutions were placed in the receiver phase (dialysis bags). Slow release rates and linear release profiles were obtained using the side-by-side diffusion cell method apparently due to limited model drug solubility in the donor chamber resulting in violation of sink conditions. Biphasic release profiles were obtained using the dialysis bag method apparently due to an initial rapid release of free and micellar solubilized model drug from the donor to the receiver chambers followed by slow release from the oil droplets. Using both release methods, an initial increase and latter decrease in release rates were observed with increase in surfactant concentration. The initial increase was considered to be due to a decrease in the model drug oil-in-water partition coefficients and the subsequent decrease in release rates was due to micellar shape change (spheres to rods) causing a decrease in diffusion rates. Sink conditions were violated using the side-by-side diffusion cell method but were maintained in the dialysis bag method since emulsions were diluted infinitely in the donor phase.

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Degradation of tragacanth by high shear and turbulent forces during microfluidization

Silvestri

Gabrielson

1991

International Journal of Pharmaceutics

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Theoretical evaluation of dispersed droplet radii in submicron oil-in-water emulsions

Cited by 8 publications

References 1 publication

In vitro release testing methods for vitamin E nanoemulsions

In vitro release testing methods for vitamin E nanoemulsions

A novel in vitro release method for submicron-sized dispersed systems

Degradation of tragacanth by high shear and turbulent forces during microfluidization

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