In vitro release testing methods for vitamin E nanoemulsions

Morais, Jacqueline M.; Burgess, Diane J.

doi:10.1016/j.ijpharm.2014.08.063

Cited by 40 publications

(15 citation statements)

References 51 publications

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“…On the basis of previous studies, 25 an Agilent 1200 series HPLC system and a Finnigan LCQ Advantage ion-trap mass spectrometer (Thermo Fisher Scientific, Waltham, MA, USA) equipped with an electrospray ionization source operating in positive ion mode were used for the analysis of plasma samples. Separation was achieved by isocratic elution using an Alltima C 18 column (250×4.6 mm, 5 μm), and the injection volume was 20 μL.…”

Section: Methodsmentioning

confidence: 99%

Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D

Hou

Jia

2016

DDDT

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BackgroundThe main purpose of this research was to design a self-nanoemulsifying drug delivery system (SNEDDS) for improving the bioavailability of cyclovirobuxine D as a poorly water-soluble drug.Materials and methodsSolubility trials, emulsifying studies, and pseudo-ternary phase diagrams were used to screen the SNEDDS formulations. The optimized drug-loaded SNEDDS was prepared at a mass ratio of 3:24:38:38 for cyclovirobuxine D, oleic acid, Solutol SH15, and propylene glycol, respectively. The optimized formulation was characterized in terms of physicochemical and pharmacokinetic parameters compared with marketed cyclovirobuxine D tablets.ResultsThe optimized cyclovirobuxine-D-loaded SNEDDS was spontaneously dispersed to form a nanoemulsion with a globule size of 64.80±3.58 nm, which exhibited significant improvement of drug solubility, rapid absorption rate, and enhanced area under the curve, together with increased permeation and decreased efflux. Fortunately, there was a nonsignificant cytotoxic effect toward Caco-2 cells. The relative bioavailability of SNEDDS was 200.22% in comparison with market tablets, in rabbits.ConclusionSNEDDS could be a potential candidate for an oral dosage form of cyclovirobuxine D with improved bioavailability.

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Section: Methodsmentioning

confidence: 99%

Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D

Hou

Jia

2016

DDDT

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“…NE was fabricated by wash-out method [12] . In this method, water phase wasadded continuously to the mixture of oil phase (mustard oil), surfactant (tween-80) and the functional compound (Vitamin E acetate).…”

Section: Preparation Of Nanoemulsionmentioning

confidence: 99%

“…The droplet diameter greatly affects the in vitro release capacity from the dispersed to continuous phases [12] . The average diameter for formulated NE (z-average) was found to be 86.45 ± 3.61 nm with the polydispersivity index (PDI) as 0.391 ± 0.43.…”

Section: Droplet Size Distribution and Zeta Potentialmentioning

confidence: 99%

Fabrication of Food Grade Vitamin E Nanoemulsion by Low Energy Approach, Characterization and Its Application

Dasgupta

Ranjan

Mundra

et al. 2015

International Journal of Food Properties

136

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The present study was carried out to fabricate the food grade vitamin E acetate nanoemulsion (NE) using edible mustard oil and to evaluate its improved bioactivities. A food-grade vitamin E acetate nanoemulsion was fabricated using the edible mustard oil and surfactant tween-80 and flocculation was not observed for 15 days. The nanoemulsion was characterized for droplet morphology and size distribution using atomic force microscope and zetasizer respectively. We observe a stable nanoemulsion of spherical morphology and a size distribution of 86.45 ± 3.61 nm. Further, the HPLC method was used to determine the vitamin E acetate concentration and encapsulation efficiency for the stable nanoemulsion. These nanoemulsions showed improved bioactivity -antioxidant and antimicrobial activity and could be potentially used to increase the shelf life of fruit juice. International Journal of Food PropertiesA c c e p t e d M a n u s c r i p t 2

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“…According to the lower release amount and slower release rate of RA from NLC and NE compared to the solution, it could be remarked that both of them exhibited a controlled release pattern. The prolonged release of RA from NE was suggested to result from the rate-limiting step of RA diffusion across the interfacial film between the internal and external phases of NE [9,50], whereas the prolonged release of RA from NLC resulted from the Fickian diffusion of RA throughout the lipid matrix of NLC [51]. The release profiles of NLC can vary from very fast release, medium release, or extremely prolonged release depending on the matrix structure, the method of production, the solubilizing properties of the surfactant for the incorporated active, and the solubility of the active in the lipid matrix [52].…”

Section: In Vitro Release Profile Of Dermal Delivery System Containinmentioning

confidence: 99%

Dermal Delivery Enhancement of Natural Anti-Ageing Compounds from Ocimum sanctum Linn. Extract by Nanostructured Lipid Carriers

et al. 2020

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This study aimed to develop nanodelivery systems for enhancing the Ocimum sanctum Linn. extract delivery into the skin. Rosmarinic acid (RA) was used as a marker for the quantitative determination of the extract by high-performance liquid chromatography. Nanostructured lipid carriers (NLC), nanoemulsion, liposome, and niosome, were developed and characterized for internal droplet size, polydispersity index (PDI), and zeta potential using photon correlation spectroscopy. Irritation properties of each formulations were investigated by hen’s egg test on the chorioallantoic membrane. In vitro release, skin permeation, and skin retention are determined. NLC was suggested as the most suitable system since it enhances the dermal delivery of RA with the significant skin retention amount of 27.1 ± 1.8% (p < 0.05). Its internal droplet size, PDI, and zeta potential were 261.0 ± 5.3 nm, 0.216 ± 0.042, and −45.4 ± 2.4 mV, respectively. RA released from NLC with a sustained release pattern with the release amount of 1.29 ± 0.15% after 24 h. NLC induced no irritation and did not permeate through the skin. Therefore, NLC containing O. sanctum extract was an attractive dermal delivery system that was safe and enhanced dermal delivery of RA. It was suggested for further used as topical anti-ageing products.

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In vitro release testing methods for vitamin E nanoemulsions

Cited by 40 publications

References 51 publications

Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D

Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D

Fabrication of Food Grade Vitamin E Nanoemulsion by Low Energy Approach, Characterization and Its Application

Dermal Delivery Enhancement of Natural Anti-Ageing Compounds from Ocimum sanctum Linn. Extract by Nanostructured Lipid Carriers

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