Theoretical calculation of some chemical properties of the cannabidiol (CBD) molecule

Abstract

Lately, many products with the active ingredient cannabidiol (CBD) have been sold around the world. Cannabidiol is an annual herb of the cannabis plant that is known to have no euphoric effects. Another type of terpenophenolic compound known as cannabinoids is also preserved in the structure of the cannabis plant. Products containing CBD are offered on the market as drugs, food supplements or dietary supplements. The US Food and Drug Administration FDA (Food and Drug Administration) has approved the oral solution of Epidiolex (cannabidiol) [CBD] for the treatment of epilepsy in patients aged two years and over. The legal assessment of commercial products containing cannabidiol (CBD) depends on the composition of the drugs available in pharmacies. Depending on whether the drugs also contain tetrahydrocannabinol (THC) in their structure in addition to CBD, criminal narcotics convictions are also decisive. In our study, some parameters related to the chemical structure of the cannabidiol (CBD) molecule were calculated using the Gaussian 09W program and the GaussView 5.0 interface program.

The Skin and Natural Cannabinoids–Topical and Transdermal Applications

“…These difficulties not only led to the use of permeability enhancers such as oleic acid and ethanol but also techniques that modify the characteristics of the molecule by using microemulsions, physical amplifiers (microneedles and electroporation), iontophoresis, ultrasound, magnetophoresis, encapsulation in micro-/nanogels, nanoparticles, and nanocarriers [25,73,76]. Cannabidiolic acid (CBDA) 4.86 [154] Cannabidiol (CBD) 5.79 [155] Cannabinodiol (CBND) 6.00 [156] Δ9-trans-tetrahidrocannabinol (THC) 7.26 [157] Δ8-trans-tetrahidrocannabinol (Δ8-THC) 7.4 [156] Cannabigerol (CBG) 7.47 [158] Cannabidiol (CBD) 5.79 [155] Pharmaceuticals 2023, 16, x FOR PEER REVIEW 16 of 35…”

“…Cannabidiolic acid (CBDA) 4.86 [154] Cannabidiol (CBD) 5.79 [155] Cannabinodiol (CBND) 6.00 [156] Δ9-trans-tetrahidrocannabinol (THC) 7.26 [157] Δ8-trans-tetrahidrocannabinol (Δ8-THC) 7.4 [156] Cannabigerol (CBG) 7.47 [158] ∆9-trans-tetrahidrocannabinol (THC) 7.26 [157] Pharmaceuticals 2023, 16, x FOR PEER REVIEW 16 of 35…”