The Skin and Natural Cannabinoids–Topical and Transdermal Applications

Abstract

The chemical constituents of the Cannabis plant known as cannabinoids have been extensively researched for their potential therapeutic benefits. The use of cannabinoids applied to the skin as a potential method for both skin-related benefits and systemic administration has attracted increasing interest in recent years. This review aims to present an overview of the most recent scientific research on cannabinoids used topically, including their potential advantages for treating a number of skin conditions like psoriasis, atopic dermatitis, and acne. Additionally, with a focus on the pharmacokinetics and security of this route of administration, we investigate the potential of the transdermal delivery of cannabinoids as a method of systemic administration. The review also discusses the restrictions and difficulties related to the application of cannabinoids on the skin, emphasizing the potential of topical cannabinoids as a promising route for both localized and systemic administration. More studies are required to fully comprehend the efficacy and safety of cannabinoids in various settings.

Socratic lectures 10 - Part I

“…The therapeutic potential of the cannabinoid CBD has been particularly researched and studied as it is abundant in the cannabis plant and has a relatively favourable legal status compared to THC. Recently, extensive review articles have been published on the therapeutic potential of phytocannabinoids, particularly cannabidiol, focusing on its effect on skin health, disease (Baswan et al, 2020;Martins et al, 2022) and delivery mechanisms (Filipiuc et al, 2023). Natural cannabinoids, including CBD, have been shown to have a positive effect in the treatment of many skin diseases (Baswan et al, 2020).…”

Breast Cancer Exposomics

“…Generally, environmental xenobiotics enter the human body through different absorption surfaces/barriers from input compartments: skin and its appendages, by topical application and absorption, gastro-intestinal mucosa, by ingestion and absorption, and the pulmonary alveolar–capillary membrane, by inhalation. To begin with, EDCs from personal care products are easily absorbed by the skin into systemic circulation after topical application, and can be detected in blood, urine, and breast milk [ 86 , 87 ]. However, Rylander et al (2019) concluded that intensive use of skin care products did not increase the BCR [ 86 ].…”

Comprehensive Insight into Cutaneous Application of Hemp

“…ECS regulates cell growth and differentiation as well as immune and inflammatory responses (Table 2). The endocannabinoids produced in the skin, N-arachidonoyletahnolamine (AEA) and 2-arachidonoylglycerol (2-AG), are binding to the main endocannabinoid receptors CB1 and CB2, as well as other receptors-TRPV1 belonging to Transient Receptor Potential (TRP) channels and PPARγ and PPARα from the Proliferator-Activated Receptors (PPAR) family [3,9]. Anti-inflammatory activity by inhibition of macrophage-1 polarization…”