Theophylline product and dosing interval selection for chronic asthma

Hendeles, Leslie; Weinberger, Miles

doi:10.1016/0091-6749(85)90643-8

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Changes Caused By Food Intake That May Affect Drug Absorption1

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1988

2023

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Cited by 15 publications

(1 citation statement)

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“…An interaction with food may cause "dose dumping" for some sustainedrelease-or controlled-release formulations such as theo-24, resulting in serious and prolonged high circulating drug levels (Hendeles and Weiberger, 1985;Zhi et al ., 1995;Welling, 1996). Coadministration of controlled-release formulations with food results in slower absorption rate and a higher fraction of drug undergoing presystemic metabolism (Welling, 1996).…”

Section: Changes Caused By Food Intake That May Affect Drug Absorptionmentioning

confidence: 99%