Effects of Food on Drug Absorption

Marasanapalle, Venugopal P.; Li, Xiaoling; Jasti, Bhaskara

doi:10.1002/9781118067598.ch14

Cited by 5 publications

(6 citation statements)

References 94 publications

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“…This mechanism has been suggested for the decrease in the bioavailability of benzoic and salicylic acid in the presence of free fatty acids. 20 Impacts of Food Matrices on PFOA Bioaccessibility. Three in vitro methods were used to determine PFOA bioaccessibility in the presence of foods.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…In addition, the bioavailability of drugs (e.g., lipoic acid and cilazapril) with molecular structures similar to PFOA is reduced when taken with foods. 20,21 PFOA orally administered to rats has been shown to be readily absorbed (93%). 22 Mice also absorbed a substantial amount of PFOA after oral administration (>50− 74%).…”

Section: In Mammalsmentioning

confidence: 99%

“…For example, using an in vivo rat model, Pu et al demonstrated the influence of soil organic carbon on the bioavailability of pentachlorophenol (PCP) in contaminated soils. In addition, the bioavailability of drugs (e.g., lipoic acid and cilazapril) with molecular structures similar to PFOA is reduced when taken with foods. , PFOA orally administered to rats has been shown to be readily absorbed (93%) . Mice also absorbed a substantial amount of PFOA after oral administration (>50–74%) .…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Bioavailability and In Vitro Bioaccessibility of Perfluorooctanoic Acid (PFOA) in Food Matrices: Correlation Analysis and Method Development

et al. 2014

Environ. Sci. Technol.

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Food is a major source of human exposure to perfluorooctanoic acid (PFOA), however, PFOA bioavailability in food has not been studied. An in vivo mouse model and three in vitro methods (unified BARGE method, UBM; physiologically based extraction test, PBET; and in vitro digestion method, IVD) were used to determine the relative bioavailability and bioaccessibility of PFOA in the presence of 17 foods. PFOA was mixed with foods of different nutritional compositions and fed to mice over a 7-d period. PFOA relative bioavailability was determined by comparing PFOA accumulation in the liver following PFOA exposure via food to that in water. PFOA bioavailability relative to water ranged from 4.30 ± 0.80 to 69.0 ± 11.9% and was negatively correlated with lipid content (r = 0.76). This was possibly due to competitive sorption of free fatty acids with PFOA onto transporters on intestine epithelial cells. Besides, cations in the gastrointestinal tract, such as Ca(2+) and Mg(2+), are capable of complexing PFOA and partitioning to the lipid phase. On the other hand, when assessed using in vitro assays, PFOA bioaccessibility varied with methods, being 8.7-73% (UBM), 9.8-99% (PBET), and 21-114% (IVD). PFOA bioaccessibility was negatively correlated with lipid content when assessed using UBM (r = 0.82); however, a poor correlation with food composition was observed for PBET and IVD (r = 0.01-0.50). When in vivo and in vitro data were compared, a strong correlation was observed for UBM (r = 0.79), but poor relationships were observed for PBET and IVD (r = 0.11-0.22). This was probably because the higher lipolysis ability and presence of Ca(2+) and Mg(2+) in the gastrointestinal fluid of UBM resulted in a lower potential to form stable micelles compared to PBET and IVD. These results indicated that PFOA relative bioavailability was mainly affected by lipid content in foods, and UBM has the potential to determine PFOA bioaccessibility in food samples.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: In Mammalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Vivo Bioavailability and In Vitro Bioaccessibility of Perfluorooctanoic Acid (PFOA) in Food Matrices: Correlation Analysis and Method Development

et al. 2014

Environ. Sci. Technol.

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“…Presence of food in stomach can alter the rate and/or extent of drug absorption either by food induced physiological changes in GIT, or by interaction between food components and drug molecules directly or indirectly [51]. Physiological changes that impart significance effect on drug absorption due to presence of food in GIT are prolonged/ delayed gastric retention time, lower gastric emptying rate, increased gastric secretions [41], variation in GI pH, enhanced bile and pancreatic secretions and splanchnic circulation [52].…”

Section: Factors Altering Dexibuprofen Absorption In Dexibuprofen-foomentioning

confidence: 99%

Effect of an Al/Mg Hydroxide Antacid and Food on the Pharmacokinetics of Dexibuprofen

et al. 2020

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Objectives In this communication we report an important findings, the effect of Al/Mg hydroxide antacid and food on the pharmacokinetics of dexibuprofen when administered concomitantly. Methods Subjects were divided into four groups, each containing 6 subjects, to evaluate the effect of antacid and food on pharmacokinetic of dexibuprofen. A new HPLC method was developed and validated for plasma sample analysis. Mobile phase was comprised of Acetonitrile: Methanol: 0.05M Phosphate buffer (40:10:50), pH was adjusted to 6.85±0.01 with NaOH. Mobile phase was eluted through C18-ODS column and drug was detected at 223 nm. Plasma was obtained and stored at − 70°C until analysis. Drug was extracted from each plasma sample of volunteer and quantified by using HPLC technique. Results A decrease in dexibuprofen absorption was observed in Test Group-1 when administered with Antacid as compared to Controlled Group-1. Mean Cmax values showed a significant (p value 0.035) decrease from 44.14±2.3 to 33.1±0.8 μg/mL. Tmax, Area under curve, t1/2, Cl, Vd and Ke were not affected significantly. AUC increased from 195.7±8.9 μg.hr/mL to 222.8±14.7 μg.hr/mL. In contrast, test Group-2 showed an increase in dexibuprofen absorption. t1/2 increased significantly from 4.505±0.19 hrs to 6.216±0.36 hrs whereas Ke reduced from 0.159±0.00 to 0.116±0.006 hrs-1. Cmax increased from 44.877±2.263 to 51.721±0.096 μg/mL. Conclusion It is concluded that concomitant intake of Al/Mg hydroxide antacid or food with dexibuprofen has an impact to significantly alter its pharmacokinetic parameters.

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“…Above there is a list of some typical examples of food/drug interactions. Interested readers may refer to Marasanapalle et al (2011 and Sørensen (2002).…”

Section: Foodmentioning

confidence: 99%