Theophylline: a review of population pharmacokinetic analyses

J., Y.; Jiang, D. Q.; Meng, Jianhua; Li, M. X.; Zhao, Hai; Wang, Y.; Wang, L. Q.

doi:10.1111/jcpt.12435

Cited by 36 publications

(26 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Clearly, this means that the results of our meta-analysis do not allow the placement of xanthines within the global COPD therapeutic framework. However, theophylline, being cheap and widely available, remains one of the most widely prescribed drugs for COPD treatment in developing countries [60]. Doxofylline, which presently is used in some regions of the world, can offer an alternative safer treatment, because of the lower risk of adverse events when compared with conventional "high-dose" theophylline, making blood monitoring unnecessary.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety profile of xanthines in COPD: a network meta-analysis

et al. 2018

View full text Add to dashboard Cite

Theophylline can still have a role in the management of stable chronic obstructive pulmonary disease (COPD), but its use remains controversial, mainly due to its narrow therapeutic window. Doxofylline, another xanthine, is an effective bronchodilator and displays a better safety profile than theophylline. Therefore, we performed a quantitative synthesis to compare the efficacy and safety profile of different xanthines in COPD.The primary end-point of this meta-analysis was the impact of xanthines on lung function. In addition, we assessed the risk of adverse events by normalising data on safety as a function of person-weeks. Data obtained from 998 COPD patients were selected from 14 studies and meta-analysed using a network approach.The combined surface under the cumulative ranking curve (SUCRA) analysis of efficacy (change from baseline in forced expiratory volume in 1 s) and safety (risk of adverse events) showed that doxofylline was superior to aminophylline (comparable efficacy and significantly better safety), bamiphylline (significantly better efficacy and comparable safety), and theophylline (comparable efficacy and significantly better safety).Considering the overall efficacy/safety profile of the investigated agents, the results of this quantitative synthesis suggest that doxofylline seems to be the best xanthine for the treatment of COPD.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy and safety profile of xanthines in COPD: a network meta-analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A. niger, Aspergillus tubingensis, Aspergillus fumigatus, Aspergillus acidus, Aspergillus awamori, A. tamarii, Blastobotrys adeninivorans, Candida tropicalis, Fusarium graminearum, Pichia farinosa, Rasamsonia byssochlamydoides, Rasamsonia emersonii, Rasamsonia cylindrospora, Rhizomucor pusillus, Rhizomucor tauricus and Thermomyces lanuginosus have been detected in pu-erh tea [28][29][30][31]. Theophylline has several applications in therapeutics, especially as anti-asthmatic, anticancer, anti-cellulite and combinatorial drug [32][33][34]. Caffeine content fluctuates during the SSF, which has associated with the fungi appearing in SSF [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Isolation, characterization and application of theophylline-degrading Aspergillus fungi

Zhou

Xia

et al. 2020

Microb Cell Fact

View full text Add to dashboard Cite

Background: Caffeine, theobromine and theophylline are main purine alkaloid in tea. Theophylline is the downstream metabolite and it remains at a very low level in Camellia sinensis. In our previous study, Aspergillus sydowii could convert caffeine into theophylline in solid-state fermentation of pu-erh tea through N-demethylation. In this study, tea-derived fungi caused theophylline degradation in the solid-state fermentation. The purpose of this study is identify and isolate theophylline-degrading fungi and investigate their application in production of methylxanthines with theophylline as feedstock through microbial conversion.Results: Seven tea-derived fungi were collected and identified by ITS, β-tubulin and calmodulin gene sequences, Aspergillus ustus, Aspergillus tamarii, Aspergillus niger and A. sydowii associated with solid-state fermentation of pu-erh tea have shown ability to degrade theophylline in liquid culture. Particularly, A. ustus and A. tamarii could degrade theophylline highly significantly (p < 0.01). 1,3-dimethyluric acid, 3-methylxanthine, 3-methyluric acid, xanthine and uric acid were detected consecutively by HPLC in A. ustus and A. tamarii, respectively. The data from absolute quantification analysis suggested that 3-methylxanthine and xanthine were the main degraded metabolites in A. ustus and A. tamarii, respectively. 129.48 ± 5.81 mg/L of 3-methylxanthine and 159.11 ± 10.8 mg/L of xanthine were produced by A. ustus and A. tamarii in 300 mg/L of theophylline liquid medium, respectively. Conclusions:For the first time, we confirmed that isolated A. ustus, A. tamarii degrade theophylline through N-demethylation and oxidation. We were able to biologically produce 3-methylxanthine and xanthine efficiently from theophylline through a new microbial synthesis platform with A. ustus and A. tamarii as appropriate starter strains.

show abstract

“…Hence, HP-β-CYD is used in this study [11]. Recently, the anticancer consequence of HP-β-CYD has been revealed and proved in vivo in mouse model of leukemia [12].…”

Section: -Introductionmentioning

confidence: 99%

“…However, in rising countries, Theophylline (THP) is at a halt the first-line treatment in patients with asthma and COPD, because it is low-priced and widely accessible. A growing amount of confirmation has recommended that low-dose THP has anti-inflammatory and immune modulatory effects in asthma and COPD and thus, THP has fascinated a large amount of awareness and importance [12,13]. THP fast metabolizers, as are started especially in the middle of children and smoking adults, may necessitate a further, regular interval than once-a-day dosing, and greater fluctuations in theophylline levels should be predictable [14].…”

Section: -Introductionmentioning

confidence: 99%

Synthesis and Characterization of Host Guest Inclusion Complexes of Cyclodextrin Molecules with Theophylline by Diverse Methodologies

et al. 2020

View full text Add to dashboard Cite

Steady host–guest inclusion complexes have been produced with medicinally important guest molecule theophylline within aqueous α-Cyclodextrin and HP-β-Cyclodextrin. α-and HP-β-Cyclodextrins have been established with favorable structural features for inclusion with Theophylline which include diversified applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing, pesticides, foodstuffs etc. Theophylline is one of the most widely accepted drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, even if it has been used clinically for many years. With both α and HP-β-Cyclodextrins it is found that 1:1 hosts-guest inclusion complexes are formed with the guest molecule theophylline. The construction and quality of the inclusion complexes have been characterized by using conductivity measurement, surface tension study, and Job’s method. The inclusion phenomenon has been confirmed by FTIR spectroscopy, proton NMR study. Association constants and thermodynamic parameters have been evaluated for the created inclusion complexes by ultraviolet spectroscopy.

show abstract

Theophylline: a review of population pharmacokinetic analyses

Cited by 36 publications

References 55 publications

Efficacy and safety profile of xanthines in COPD: a network meta-analysis

Efficacy and safety profile of xanthines in COPD: a network meta-analysis

Isolation, characterization and application of theophylline-degrading Aspergillus fungi

Synthesis and Characterization of Host Guest Inclusion Complexes of Cyclodextrin Molecules with Theophylline by Diverse Methodologies

Contact Info

Product

Resources

About