Thein VitroEffect on T Cell Function of Soluble IL-2Rα from Advanced Ovarian Cancer Ascites

Elg, Steven A.; Hill, Robert B.; Heldman, Leslie S.; Ramakrishnan, Sundaram

doi:10.1006/gyno.1997.4741

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Ovarian cancer is often accompanied by ascites, which shows a highly variable molecular composition between EOC patients (128). Numerous immunosuppressive factors have been identified in ascites, including IL-10 (129-132), Fas ligand (133)(134)(135)(136)(137)(138)(139)(140), TNF-a (35,141,142), TGFb (130,132,143,144), VEGF (20-22, 35, 145, 146), B7-H1/PD-L1 (29,31,147), B7-H4 (60,(148)(149)(150), SDF-1 (151), EBAG9/RCAS1 (152)(153)(154), and soluble IL-2 receptor (155)(156)(157). Thus, the contribution of various immunoregulatory factors to the composition and function of TILs is a complex issue.…”

Section: Which Factors Influence the Composition And Function Of Tumomentioning

confidence: 99%

The impact of T‐cell immunity on ovarian cancer outcomes

Nelson

2008

Immunological Reviews

144

119

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Ovarian cancer remains a challenging disease for which improved treatments are urgently needed. Most patients present with advanced disease that is highly responsive to surgery combined with platinum- and taxane-based chemotherapy, with a state of minimal residual disease being achieved in many cases. However, chemotherapy-resistant recurrent tumors typically appear within 1-5 years and are ultimately fatal. Recently, several groups have shown that ovarian tumors are often infiltrated by activated T cells at the time of diagnosis, and patients with dense infiltrates of CD3+CD8+ T cells experience unexpectedly favorable progression-free and overall survival. Other cell types in the immune infiltrate oppose anti-tumor immunity, including CD4+CD25+FoxP3+ regulatory T cells, CD8+ regulatory T cells, macrophages, and dendritic cells. The composition of immune infiltrates is shaped by the expression of cytokines, chemokines, antigens, major histocompatibility complex molecules, and costimulatory molecules. The relationship between these various immunological factors is reviewed here with a strong emphasis on outcomes data so as to create a knowledge base that is well grounded in clinical reality. With improved understanding of the functional properties of natural CD8+ T-cell responses to ovarian cancer, there is great potential to improve clinical outcomes by amplifying host immunity.

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