The κ-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety

Marco, Eva M.; Llorente, Ricardo; Pérez-Álvarez, Laura; Moreno, Enrique; Guaza, Carmen; Viveros, María-Paz

doi:10.1016/j.bbr.2005.05.005

Cited by 27 publications

(18 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While normally suggestive of an anxiolytic-like action, this change was not paralleled by an increase in percent open arm time (Table 4) and appeared to derive as much from a decrease in closed-arm entries as an increase in open-arm entries-an interpretation confirmed statistically when the closed-arm entry score was factored out in an analysis of covariance. This negative finding with nor-BNI in the mouse plus-maze is again consistent with previous studies over a comparable dose range in rats and several mouse strains (Tsuda et al 1996;Agmo and Belzung 1998;Berrendero and Maldonado 2002;Marin et al 2003;Saitoh et al 2004;Balerio et al 2005;Marco et al 2005).…”

Section: Discussionsupporting

confidence: 91%

Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes

et al. 2006

View full text Add to dashboard Cite

Recent evidence suggests differential involvement of opioid receptor subtypes in the anxiolytic efficacy of diverse compounds including conventional benzodiazepines. The insensitivity of 129 mice to the anxiolytic action of chlordiazepoxide, coupled with their atypical anxiolytic response to naloxone (but not more selective opioid receptor antagonists), suggests an abnormality in anxiety-related neurocircuitry involving opioid-GABA interactions.

show abstract

Section: Discussionsupporting

confidence: 91%

Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Systemic administration of high doses of nicotine can also have the independent effect of reducing locomotor activity (Marco et al, 2005, Ouagazzal et al, 1999aTucci et al, 2003b).This effect is also seen after local application into the lateral septal nucleus (Ouagazzal et al, 1999b), suggesting this area is important for mediating the effects on locomotor activity. This is in contrast with the dorsal hippocampus, where local administration of nicotine has an anxiogenic effect, but does not change locomotor activity (File et al, 1998).…”

Section: Unconditioned Anxietymentioning

confidence: 92%

“…Similar to other anxiogenic drugs, both cannabinoids (Viveros et al, 2005b) and nicotine (Marco et al, 2005) can induce increased anxiety together with stimulation of adrenocortical activity. However, the two effects are dissociable.…”

Section: Unconditioned Anxietymentioning

confidence: 99%

Nicotine and cannabinoids: Parallels, contrasts and interactions

Viveros

Marco

File

2006

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

“…For example, while caffeine also increased rearing behavior in the Open Field and BPM, as well as holepoking in the holeboard and BPM (Collins et al 1979,Geyer et al 1986,Meliska and Loke 1984,Rao et al 1999, nicotine had no effect on rearing behavior in the Open Field or BPM (Geyer et al 1986,Meliska andLoke 1984). In fact, higher doses of nicotine reduced the amounts of locomotion and holepoking behavior (Marco et al 2005,Marks et al 1986), likely due to hypothermic effects. Likewise phencyclidine can raise or lower exploratory levels dependent upon dose (Krebs-Thompson et al 1998).…”

Section: Assessing Multivariate Behavioral Profilesmentioning

confidence: 99%

A reverse-translational approach to bipolar disorder: Rodent and human studies in the Behavioral Pattern Monitor

Young

Minassian

Paulus

et al. 2007

Neuroscience & Biobehavioral Reviews

106

View full text Add to dashboard Cite

Mania is the defining feature of Bipolar Disorder (BD). There has been limited progress in understanding the neurobiological underpinnings of BD mania and developing novel therapeutics, in part due to a paucity of relevant animal models with translational potential. Hyperactivity is a cardinal symptom of mania, traditionally measured in humans using observer-rated scales. Multivariate assessment of unconditioned locomotor behavior using the rat Behavioral Pattern Monitor (BPM) developed in our laboratory has shown that hyperactivity includes complex multifaceted behaviors. The BPM has been used to demonstrate differential effects of drugs on locomotor activity and exploratory behavior in rats. Studies of genetically engineered mice in a mouse BPM have confirmed its utility as a cross-species tool. In a "reverse-translational" approach to this work, we developed the human BPM to characterize motor activity in BD patients. Increased activity, object interactions, and altered locomotor patterns provide multidimensional phenotypes to model in the rodent BPM. This unique approach to modeling BD provides an opportunity to identify the neurobiology underlying BD mania and test novel antimanic agents. KeywordsBipolar Disorder; mania; locomotor activity; exploratory; rat; mouse; Behavioral Pattern Monitor; Open Field; hyperactivity Modeling BD maniaBipolar disorder (BD) is a severe psychiatric disorder that affects approximately 2-7% of the general population (Friedman et al. 2006). Mania is the defining feature of BD although patients can also manifest depressive symptoms. During the manic episodes of BD, patients exhibit impulsive behavior, hypersexuality, pressured speech, flight of ideas, and motor hyperactivity, which have been conceptualized as inhibitory failures of behavior and thought (Goodwin and Jamison 1990). These symptoms profoundly impair and disrupt social, occupational, and family life in individuals with BD (Post et al. 2003). Despite the prevalence of this disorder, surprisingly few studies (Franks et al. 1983,Gooding and Tallent 2001,Murphy et al. 1999, have attempted to develop adequate translational models to elucidate the neurobiology * Correspondence should be sent to: Martin P. Paulus, M.D. Department of Psychiatry, UCSD, La Jolla, California, 92093-9116 Phone: (858) Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeurosci Biobehav Rev. Author manuscript; available in PMC 2008 January 1. Published in final edited form as:Neurosci Biobehav Rev. 2007 ; 31(6): 882-896. NIH-PA Author ManuscriptNIH-PA Author Manu...

show abstract

The κ-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety

Cited by 27 publications

References 30 publications

Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes

Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes

Nicotine and cannabinoids: Parallels, contrasts and interactions

A reverse-translational approach to bipolar disorder: Rodent and human studies in the Behavioral Pattern Monitor

Contact Info

Product

Resources

About