The β-blocker propranolol affects cAMP-dependent signaling and induces the stress response in Mediterranean mussels, Mytilus galloprovincialis

Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers

“…Glutathione peroxidase (GPx) plays an important protective role by acting as a scavenger for high levels of hydrogen peroxide; during this process, glutathione is oxidized and loses its protective antioxidant potential (Nunes et al, 2006). Some pharmaceutical compounds may stimulate the production of ROS, eliciting oxidative damage to aquatic organisms including fish and invertebrates as verified in studies with acetaminophen (Solé et al, 2010;Gómez-Oliván et al, 2012;Antunes et al, 2013;Sung et al, 2014), chlorpromazine (Li et al, 2008), sodium diclofenac (Oviedo-Gómez et al, 2010;Parolini and Binelli, 2012;Parolini et al, 2013;Nava-Álvarez et al, 2014) and propranolol (Solé et al, 2010;Franzellitti et al, 2011).…”

General stress, detoxification pathways, neurotoxicity and genotoxicity evaluated in Ruditapes philippinarum exposed to human pharmaceuticals

“…In addition, biochemical biomarkers (considered to be parameters of chemical exposure and effect) have indicated the presence, availability, and toxicity of pharmaceuticals in several studies. For example, the induction of activities of biotransformation enzymes and oxidative stress, have indicated cellular detoxification against these compounds in D. polymorpha (Contardo-Jara et al, 2011), M. galloprovincialis (Franzellitti et al, 2011(Franzellitti et al, , 2013Martín-Díaz et al, 2009a, Venerupis decussata and Venerupis philippinarum (clams) (Antunes et al, 2013), Corbicula fluminea (clam) (Aguirre-Martínez et al, 2015a, 2015bChen et al, 2014), Oncorhynchus mykiss (fish) (Gagné et al, 2006;Li et al, 2011), and Hediste diversicolor (polychaete) (Maranho, et al 2014) among others. Toxicity of these compounds have also been evaluated through neurotoxic and genotoxic effects in V. philippinarum (Munari et al, 2014), H. diversicolor (Maranho et al, 2014), Ampelisca brevicornis (amphipod) (Maranho et al, 2015), Elliptio complanata (mussel) , M. galloprovincialis (Franzellitti et al, 2013), and D. polymorpha (Quinn et al, 2011) to name a few.…”

Genotoxicity and activation of cellular defenses in transplanted zebra mussels Dreissena polymorpha along the Seine river

“…PgP has been demonstrated to be involved in excretion of PAHs from cells (Kurelec, 1995) and hence indicated the process by which the mussel eliminates the pollutants from its cells, suggesting a detoxification process in mussels transplanted. An up-regulation of P-gP mRNA was also observed after mussel exposure to the β-blocker metroprolol (Contardo-Jara et al, 2010) and to the propanolol (Franzellitti et al, 2011), thus demonstrating elimination process. However, for the severely contaminated site located at Triel (Michel et al, 2013), P-gP expression was lower.…”