The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1

Sun, Mengyao; Wang, Dandan; Sun, Jian; Zhao, Xiaohua; Cai, Si; Wu, Qiu-Xue; Tao, Jie; Ni, Zhenhua; Sun, Jianyue; Tang, Qingfeng

doi:10.1016/s1875-5364(19)30022-6

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…Although specific targets vary, most natural products aimed to prevent drug resistance by downregulating Akt and NF-κB and following pathways (Figure 4). Bufalin from Venenum bufonis and the Zuo Jin Wan formula effectively down-regulated Akt [139,143]. Similarly, the mineral isorhamnetin from Quercetin inhibited cell viability and prevented drug resistance by downregulating NF-κB [130].…”

Section: Chemotherapy Resistance and Natural Products In Gastric Cancermentioning

confidence: 98%

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Emerging Potential of Naturally Occurring Molecules against Gastric Cancer: Insights Molecular Mechanism and Therapeutic Targets

Kang¹,

Hwang²,

Shin³

et al. 2021

Preprint

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Gastric cancer, also known as stomach cancer, is a cancer which develops from the lining of the stomach. Accumulated evidences and epidemiological studies have been indicated that natural products play an important role in gastric cancer prevention and treatment, although its mechanism of action did not elucidate yet. Particularly, experimental studies have been showed that natural products displayed a protective effect against gastric cancer via numerous molecular mechanisms such as suppression of cell metastasis, anti-angiogenesis, inhibition of cell proliferation, induction of apoptosis, and modulation of autophagy. Although chemotherapy remains the standard treatment for advanced gastric cancer along with surgery, radiation therapy, hormone therapy and immunotherapy, but its adverse side effects including neutropenia, stomatitis, mucositis, diarrhea, nausea, and emesis are well documented. Additionally, intake of naturally occurring phytochemicals could increase the efficacy of gastric chemotherapy and chemotherapeutics resistance. However, natural product structural stability and powerful bioactivity are important to develop novel treatments for gastric cancer that may minimize such adverse effects. Therefore, the purpose of this review is to summarize the potential therapeutic effects of natural products on prevention and treatment of gastric cancer with intensive molecular mechanisms of action, bioavailability, and safety efficacy.

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Section: Chemotherapy Resistance and Natural Products In Gastric Cancermentioning

confidence: 98%

“…Fructus (Rutaceae) in the ratio of 6:1. Sun et al reported that Zuo Jin Wan Formula induced apoptosis in primary DDP-resistant gastric carcinoma cells by stimulating cofilin-1 mitochondrial translocation [143]. Translocation of cofilin-1 was mediated by Akt.…”

Section: Chemotherapy Resistance and Natural Products In Gastric Cancermentioning

confidence: 99%

Emerging Potential of Naturally Occurring Molecules against Gastric Cancer: Insights Molecular Mechanism and Therapeutic Targets

Kang¹,

Hwang²,

Shin³

et al. 2021

Preprint

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“…As well as the monomers and extracts derived from TCMs, an increasing body of evidence suggests that TCM formulas possess anticancer properties, too. Zuo Jin Wan (ZJW) has been used in the treatment of gastrointestinal and liver diseases in China for ages ( Chao et al, 2011 ; Sun et al, 2019 ), which is composed of Rhizoma Coptidis and Evodia Rutaecarpa at a ratio of 6:1. Berberine and evodiamine are two key elements of ZJW extract and possess anti-tumorigenic activity, respectively ( Ayati et al, 2017 ; Wang et al, 2019 ).…”

Section: Effect Of Tcm Formulas On Crcmentioning

confidence: 99%

Potential Role of Traditional Chinese Medicines by Wnt/β-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy

et al. 2021

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Colorectal cancer (CRC) has become a global public health problem because of its high incidence and mortality rate worldwide. The previous clinical treatment for CRC mainly involves conventional surgery, chemotherapy, and radiotherapy. With the development of tumor molecular targeted therapy, small molecule inhibitors present a great advantage in improving the survival of patients with advanced CRC. However, various side effects and drug resistance induced by chemotherapy are still the major obstacles to improve the clinical benefit. Thus, it is crucial to find new and alternative drugs for CRC treatment. Traditional Chinese medicines (TCMs) have been proved to have low toxicity and multi-target characteristics. In the last few decades, an increasing number of studies have demonstrated that TCMs exhibit strong anticancer effects in both experimental and clinical models and may serve as alternative chemotherapy agents for CRC treatment. Notably, Wnt/β-catenin signaling pathway plays a vital role in the initiation and progression of CRC by modulating the stability of β-catenin in the cytoplasm. Targeting Wnt/β-catenin pathway is a novel direction for developing therapies for CRC. In this review, we outlined the anti-tumor effects of small molecular inhibitors on CRC through Wnt/β-catenin pathway. More importantly, we focused on the potential role of TCMs against tumors by targeting Wnt/β-catenin signaling at different stages of CRC, including precancerous lesions, early stage of CRC and advanced CRC. Furthermore, we also discussed perspectives to develop potential new drugs from TCMs via Wnt/β-catenin pathway for the treatment of CRC.

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“…18,19 Furthermore, ZJW extracts inhibit CRC cells growth and invasion, and enhance the sensitivity of chemotherapy of CRC cells and gastric cancer cells to chemotherapy. [20][21][22] Similar to other TCM formulae, ZJW involves multiple components, targets, and pathways against tumors. However, its major bioactive ingredients and pharmacological molecular mechanism against CRC remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

<p>Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer</p>

Huang

Zhang

et al. 2020

DDDT

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Background: Zuojinwan (ZJW), a famous Chinese medicine formula, has been widely used to treat colorectal cancer (CRC). However, its bioactive compounds, potential targets, and molecular mechanism remain largely elusive. Aim: A network pharmacology-based strategy combined with molecular docking studies and in vitro validation were employed to investigate bioactive compounds, potential targets, and molecular mechanism of ZJW against CRC. Materials and Methods: Bioactive compounds and potential targets of ZJW, as well as related genes of CRC, were acquired from public databases. Important ingredients, potential targets, and signaling pathways were determined through bioinformatics analysis, including protein-protein interaction (PPI), the Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, molecular docking and cell experiments were performed to further verify the findings. Results: A total of 36 bioactive ingredients of ZJW and 163 gene targets of ZJW were identified. The network analysis revealed that quercetin, baicalein, wogonin, beta-sitosterol, and isorhamnetin may be candidate agents. The AKT1, JUN, CDKN1A, BCL2L1, and NCOA1 could become potential drug targets. The KEGG indicated that PI3K-AKT signaling pathway may play an important role in the effect of ZJW against CRC. Molecular docking suggested that quercetin, baicalein, and wogonin combined well with AKT1 and JUN. The in vitro experiment showed that quercetin, the most important ingredient of ZJW, could induce apoptosis of HCT116 cells through PI3K-Akt signaling pathway. This finding was congruent with the prediction obtained through the network pharmacology approach. Conclusion: This study comprehensively illuminated the active ingredients, potential targets, and molecular mechanism of ZJW against CRC. It also provided a promising approach to uncover the scientific basis and therapeutic mechanism of traditional Chinese medicine (TCM) formula treating for disease.

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The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1

Cited by 7 publications

References 34 publications

Emerging Potential of Naturally Occurring Molecules against Gastric Cancer: Insights Molecular Mechanism and Therapeutic Targets

Emerging Potential of Naturally Occurring Molecules against Gastric Cancer: Insights Molecular Mechanism and Therapeutic Targets

Potential Role of Traditional Chinese Medicines by Wnt/β-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy

<p>Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer</p>

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