The Zanthoxylum schinifolium seed oil modulates immune function under the biological safety level

Seo, Joung‐Wook; Park, Dae-Hun; Li, Yongchun; Kang, Hur-Je; Xu, Hao; Kim, Young‐Jin; Lee, Jong-Hwa; Lee, Myung-Sup; Lee, In Chul; Lee, Yun Lyul; Ahn, Jae-Bum; Cho, Soon-Chang; Lee, Min-Jae

doi:10.1007/s13273-012-0022-8

Cited by 7 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fruits from this genus are commonly used as spices, antiseptics, and insecticides worldwide. Earlier studies have shown that Zanthoxylum plants have antioxidant, antibacterial, insecticidal, immunomodulatory, anti-malignant cell proliferation, anti-inflammatory, and analgesic properties [2][3][4][5][6][7]. Zanthoxylum acanthopodium DC., mainly distributed in China, Myanmar, India, and Nepal, is used as a medicine to cure many diseases and as a spice in cooking by local people [1].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antifungal, Anti-Inflammatory, Antiviral, and Larvicidal Activities of the Essential Oils of Zanthoxylum acanthopodium DC. from China and Myanmar

Yang

Song

et al. 2022

Molecules

View full text Add to dashboard Cite

Zanthoxylum acanthopodium DC. is a widely used traditional medicinal plant to treat fever, flu, stomachache, traumatic injury, and mosquito bite in tropical and subtropical Asia. This study aimed to investigate the antifungal, anti-inflammatory, antiviral, and larvicidal activities of its fruit essential oil. The essential oil sample from China (EOZC) was mainly composed of limonene (29.78%) and β-myrcene (26.65%), while the sample from Myanmar (EOZM) was dominated by Terpinen-4-ol (43.35%). Both essential oils showed antifungal activity, with 90% minimum inhibitory concentration (MIC90) values ranging from 26.3 to 499 μg/mL. By obviously inhibiting nitric oxide (NO) in RAW 264.7 cells, EOZC (IC50, 16 μg/mL) showed comparable anti-inflammatory activity to the positive control L-NMMA (IC50, 12.2 μg/mL). EOZM showed significant antiviral activity against the dengue virus with an IC50 value of 13 μg/mL. Additionally, both EOZC and EOZM demonstrated dose-dependent larvicidal activity against Aedes albopictus, with LC50 and LC90 values ranging from 45.8 to 144.0 μg/mL. Our results contribute a theoretical foundation for the further application of Zanthoxylum acanthopodium DC. as an antifungal and anti-inflammatory ingredient in the pharmaceutical industry and further indicate that it has the potential to be developed as a new source of natural and eco-friendly medicine for the prevention and treatment of dengue virus.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antifungal, Anti-Inflammatory, Antiviral, and Larvicidal Activities of the Essential Oils of Zanthoxylum acanthopodium DC. from China and Myanmar

Yang

Song

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…Recently, research to find immune modulating materials in natural products is being actively carried out [19,20,21,22,23]. This research has produced many immune modulating candidates including those with immunostimulating properties such as Stephania delavayi Diels., Zanthoxylum schinifolium , Alpinia galanga , and Panax ginseng, although the method of activation differs between the materials.…”

Section: Discussionmentioning

confidence: 99%

“…suppresses TNF-α [ 8 ]. IFN-γ improves chronic granulomatous disease and malignant osteopetrosis [ 23 ]; IL-2 regulates lymphocyte differentiation, immune responses, and homeostasis and especially controls regulatory T (T Reg ) cells and differentiating CD4 T cells [ 10 ]; and IFN-γ and IL-2 are decreased by acute swim stress [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Immunostimulating Effects of Extract of <i>Acanthopanax sessiliflorus</i>

et al. 2013

View full text Add to dashboard Cite

As malfunction/absence of immune cells causes a variety of immunosuppressive disorders and chemical synthetic drugs for curing these diseases have many adverse effects, vigorous studies are being conducted. The Acanthopanax family has been used as traditional medicines for gastric ulcer, diabetes, etc. and culinary materials in East-South Asia. In this study, the immunostimulating properties of A. sessiliflorus were evaluated. A. sessiliflorus increased not only the splenocyte number but also immune-related cytokines such as TNF-α. However, it could not upregulate the expressions of IFN-γ and IL-2. A. sessiliflorus increased the swimming time, and comparison of organ weights relative to body weights for immune-related organs such as the spleen and thymus after a forced swim test showed that it could recover the spleen and thymus weights. It also increased the expression of TNF-α and slightly increased the concentration of IFN-γ but not IL-2. From the results, we concluded that as A. sessiliflorus has not only a host defense effect but also a stress-ameliorating property, further study it will be a promising material of immunostimulating material.

show abstract

“…Nativo da China, Japão e Coréia, Z. schinifolium é uma arbusto aromático com folhas caducifólias, que cresce a 5-7 m (Paik et al 2005). Seu fruto é amplamente utilizado como um condimento e tempero na Coréia e outros países do Leste Asiático, o óleo extraído das sementes ainda é usado nestes países na medicina tradicional para dor epigástrica, atividade anticancerígena, anti-inflamatória (Seo et al 2012), antidiabetes (Fang et al 2010) e para revigorar a circulação do sangue e como analgésico (Cui et al 2009, Min et al 2011.…”

Section: Zanthoxylum Schinifolium Sieb Et Zuccunclassified

Compostos químicos isolados de extratos e óleos essenciais do gênero Zanthoxylum Linnaeus (Rutaceae) e seu potencial antimicrobiano

Filho

Sousa

Santos

et al. 2020

Hoehnea

View full text Add to dashboard Cite

RESUMO Este artigo de revisão reporta ao estudo químico e farmacológico de metabolitos secundários isolados de 20 espécies do gênero Zanthoxylum Linnaeus. Os constituintes químicos voláteis e fixos das espécies desse gênero foram isolados e caracterizados por métodos analíticos. Esta revisão foi realizada através da busca organizada de Dissertações de Mestrado, Teses de Doutorado e principalmente artigos científicos publicados sobre estudos fotoquímicos e atividades antimicrobianas das espécies do gênero Zanthoxylum disponíveis nos Periódicos CAPES, PubMed, ScienceDirect, Scopus, Scielo e Google Acadêmico entre 1985 e 2019. As espécies apresentaram composição química diversificada onde predominam alcaloides, terpenos e cumarinas com diferentes tipos de atividades antimicrobianas, tais como: antifúngica, antibiótica, antiprotozoário e antiviral.

show abstract

The Zanthoxylum schinifolium seed oil modulates immune function under the biological safety level

Cited by 7 publications

References 11 publications

Chemical Composition and Antifungal, Anti-Inflammatory, Antiviral, and Larvicidal Activities of the Essential Oils of Zanthoxylum acanthopodium DC. from China and Myanmar

Chemical Composition and Antifungal, Anti-Inflammatory, Antiviral, and Larvicidal Activities of the Essential Oils of Zanthoxylum acanthopodium DC. from China and Myanmar

Immunostimulating Effects of Extract of <i>Acanthopanax sessiliflorus</i>

Compostos químicos isolados de extratos e óleos essenciais do gênero Zanthoxylum Linnaeus (Rutaceae) e seu potencial antimicrobiano

Contact Info

Product

Resources

About