The Yin and Yang of dietary gluten transgressions in real-life scenarios of celiac patients

Lerner, Aaron; Tenbusch, Matthias

doi:10.1186/s12916-020-01535-8

“…Those three interrelated pathways are the basis for our current novel hypothesis, whereby, two very common environmental domains, plants and microbes, and gluten and mTG, respectively, are joining together to induce autoimmunity and other gluten-dependent inflammatory diseases 4 , 7 , 9 , 22 , 26 , 27 , 32 , 39 , 41 . Interestingly, gluten avoidance was recently reported to alleviate symptoms and disease activity of non-celiac ADs 81 , 82 , 102 – 106 , although, gluten withdrawal is not devoid of side effects 107 – 109 . Taken together, both external factors, the mTG and gluten-containing nutrients, can operate as the mythological Trojan horse to drive luminal and extra-intestinal ADs 29 .…”

Section: Discussionmentioning

confidence: 99%

Cross-reactivity and sequence similarity between microbial transglutaminase and human tissue antigens

Lerner,

Benzvi,

Vojdani

2023

Sci Rep

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Microbial transglutaminase (mTG) is a bacterial survival factor, frequently used as a food additive to glue processed nutrients. As a result, new immunogenic epitopes are generated that might drive autoimmunity. Presently, its contribution to autoimmunity through epitope similarity and cross-reactivity was investigated. Emboss Matcher was used to perform sequence alignment between mTG and various antigens implicated in many autoimmune diseases. Monoclonal and polyclonal antibodies made specifically against mTG were applied to 77 different human tissue antigens using ELISA. Six antigens were detected to share significant homology with mTG immunogenic sequences, representing major targets of common autoimmune conditions. Polyclonal antibody to mTG reacted significantly with 17 out of 77 tissue antigens. This reaction was most pronounced with mitochondrial M2, ANA, and extractable nuclear antigens. The results indicate that sequence similarity and cross-reactivity between mTG and various tissue antigens are possible, supporting the relationship between mTG and the development of autoimmune disorders 150W.

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“…Interestingly, gluten avoidance was recently reported to alleviate symptoms and disease activity of nonceliac ADs 81,82, 102-106 , although, gluten withdrawal is not devoid of side effects [107][108][109] . Taken together, both external factors, the mTG and gluten-containing nutrients, can operate as the mythological Trojan horse to drive luminal and extra-intestinal ADs 29 .…”

Section: Discussionmentioning

confidence: 99%

Cross-Reactivity and sequence similarity between microbial transglutaminase and human antigens: expanded exposome of autoimmune diseases

Lerner

¹

,

Benzvi

²

,

Vojdani

³

2023

Preprint

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0

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Microbial transglutaminase (mTG) is a bacterial survival factor, frequently used as a food additive to glue processed nutrients. As a result, new immunogenic epitopes are generated that might drive autoimmunity. Presently, its contribution to autoimmunity through epitope similarity and cross-reactivity was investigated. Emboss Matcher was used to perform sequence alignment between mTG and various antigens implicated in many autoimmune diseases. Monoclonal and polyclonal antibodies made specifically against mTG were applied to 77 different human tissue antigens using ELISA. Six antigens were detected to share significant homology with mTG immunogenic sequences, representing major targets of common autoimmune conditions. Polyclonal antibody to mTG reacted significantly with 17 out of 77 tissue antigens. This reaction was most pronounced with mitochondrial M2, ANA, and extractable nuclear antigens. The results indicate that sequence similarity and cross-reactivity between mTG and various tissue antigens are possible, supporting the relationship between mTG and the development of autoimmune disorders. 150W

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Gluten-free diet can ameliorate the symptoms of non-celiac autoimmune diseases

Lerner

¹

,

Carvalho

²

,

Kotrova

³

et al. 2021

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Context A gluten-free diet (GFD) is the recommended treatment for gluten-dependent disease. In addition, gluten withdrawal is popular and occasionally is suggested as a treatment for other autoimmune diseases (ADs). Objective The current systematic review summarizes those entities and discusses the logic behind using a GFD in classical non–gluten-dependentADs. Data Sources A search for medical articles in PubMed/MEDLINE, Web of Sciences, LILACS, and Scielo published between 1960 and 2020 was conducted, using the key words for various ADs and GFDs. Data Exxtraction Eight-three articles were included in the systematic review (using PRISMA guidelines). Data Analysis Reduction in symptoms of ADs after observance of a GFD was observed in 911 out of 1408 patients (64.7%) and in 66 out of the 83 selected studies (79.5%). The age of the patients ranged from 9 months to 69 years. The duration of the GFD varied from 1 month to 9 years. A GFD can suppress several harmful intraluminal intestinal events. Potential mechanisms and pathways for the action of GFD in the gut – remote organs’ axis have been suggested. Conclusion A GFD might represent a novel nutritional therapeutic strategy for classical non–gluten-dependent autoimmune conditions.

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The Yin and Yang of dietary gluten transgressions in real-life scenarios of celiac patients

Cited by 6 publications

References 9 publications

Cross-reactivity and sequence similarity between microbial transglutaminase and human tissue antigens

Cross-reactivity and sequence similarity between microbial transglutaminase and human tissue antigens

Cross-Reactivity and sequence similarity between microbial transglutaminase and human antigens: expanded exposome of autoimmune diseases

Gluten-free diet can ameliorate the symptoms of non-celiac autoimmune diseases

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