The yield of endometrial aspiration in women with various risk factors and bleeding abnormalities

Nelson, Anita L.; Vasquez, Lisa; Tabatabai, Roya; Im, Samuel S.

doi:10.1186/s40834-016-0020-7

Cited by 7 publications

(3 citation statements)

References 61 publications

(54 reference statements)

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“…[ 9 ] and Kaur et al . [ 10 ] in India as well as in western countries [ 11 12 ] where endometrial aspiration was compared with traditional methods for adequacy of samples.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Uterine Bleeding- evaluation by Endometrial Aspiration

Singh¹

2018

J Mid-life Health

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Endometrial evaluation is generally indicated in cases presenting with abnormal uterine bleeding (AUB), especially in women more than 35 years of age. AUB encompasses a variety of presentation, for example, heavy menstrual bleeding, frequent bleeding, irregular vaginal bleeding, postcoital and postmenopausal bleeding to name a few. Many methods are used for the evaluation of such cases, with most common being sonography and endometrial biopsy with very few cases requiring more invasive approach like hysteroscopy. Endometrial aspiration is a simple and safe office procedure used for this purpose.Materials and Methods:We retrospectively analyzed cases of AUB where endometrial aspiration with Pipette (Medgyn) was done in outpatient department between January 2015 and April 2016. Case records (both paper and electronic) were used to retrieve data.Results:One hundred and fifteen cases were included in the study after applying inclusion and exclusion criteria. Most cases were between 46 and 50 years of age followed by 41–45 years. No cases were below 25 or more than 65 years of age. Heavy menstrual bleeding was the most common presentation of AUB. Adequate samples were obtained in 86% of cases while 13.9% of cases' sample was inadequate for opinion, many of which were later underwent hysteroscopy and/or dilatation and curettage (D and C) in operation theater; atrophic endometrium was the most common cause for inadequate sample. Uterine malignancy was diagnosed in three cases.Discussion:Endometrial aspiration has been compared with traditional D and C as well as postoperative histopathology in various studies with good results. Many such studies are done in India as well as in western countries confirming good correlation with histopathology and adequate tissue sample for the pathologist to give a confident diagnosis. No complication or side effect was noted with the use of this device.Conclusion:Endometrial aspiration is a simple, safe, and effective method to sample endometrium in cases of AUB avoiding risk of anesthesia and is less time-consuming. Many similar devices are also available in the market and need to be popularized in all parts of the country.

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“…[ 9 ] and Kaur et al . [ 10 ] in India as well as in western countries [ 11 12 ] where endometrial aspiration was compared with traditional methods for adequacy of samples.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Uterine Bleeding- evaluation by Endometrial Aspiration

Singh¹

2018

J Mid-life Health

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“…Early diagnosis of EC in younger patients is suggested to be lower and can easily be misdiagnosed as abnormal uterine bleeding, whereas older patients are more likely to be diagnosed at an early stage [ 8 ]. Nelson et al [ 9 ] found no association between increasing age and the prevalence of endometrial hyperplasia, which was more common in women aged < 40 years than in those aged 40–50 years. Clinically, patients younger than 45 years were defined as having early onset EC.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for predicting overall survival in patients with early-onset endometrial cancer

Zhang,

Li,

Zhang

et al. 2023

BMC Cancer

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Background This study aimed to investigate the differences in the clinicopathological characteristics of younger and older patients with endometrial cancer (EC) and develop a nomogram to assess the prognosis of early onset EC in terms of overall survival. Methods Patients diagnosed with EC from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015 were selected. Clinicopathological characteristics were compared between younger and older patients, and survival analysis was performed for both groups. Prognostic factors affecting overall survival in young patients with EC were identified using Cox regression. A nomogram was created and internal validation was performed using the consistency index, decision curve analysis, receiver operating characteristic curves, and calibration curves. External validation used data from 70 patients with early onset EC. Finally, Kaplan-Meier curves were plotted to compare survival outcomes across the risk subgroups. Results A total of 1042 young patients and 12,991 older patients were included in this study. Younger patients were divided into training (732) and validation (310) cohorts in a 7:3 ratio. Cox regression analysis identified age, tumorsize, grade, FIGO stage(International Federation of Gynecology and Obstetrics) and surgery as independent risk factors for overall survival, and a nomogram was constructed based on these factors. Internal and external validations demonstrated the good predictive power of the nomogram. In particular, the C-index for the overall survival nomogram was 0.832 [95% confidence interval (0.797–0.844)] in the training cohort and 0.839 (0.810–0.868) in the internal validation cohort. The differences in the Kaplan-Meier curves between the different risk subgroups were statistically significant. Conclusions In this study, a nomogram for predicting overall survival of patients with early onset endometrial cancer based on the SEER database was developed to help assess the prognosis of patients and guide clinical treatment.

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“…Endometrial carcinoma, which is the most frequent gynecologic malignancy in the United States, often presents with abnormal uterine bleeding. As a result, endometrial sampling is part of the diagnostic evaluation for AUB in women with risk factors, including obesity, null parity, significant family history and postmenopausal bleeding [1][2][3]. The specific indication for performing endometrial biopsy, however, varies amongst expert panels.…”

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confidence: 99%