The Yersinia pseudotuberculosis complex: Characterization and delineation of a new species, Yersinia wautersii

Savin, Cyril; Martin, Liliane; Bouchier, Christiane; Filali, Sofia; Chenau, Jérôme; Zhou, Zhemin; Bécher, François; Fukushima, Hiroshi; Thomson, Nicholas R.; Scholz, Holger C.; Carniel, Élisabeth

doi:10.1016/j.ijmm.2014.02.002

Cited by 52 publications

(39 citation statements)

References 49 publications

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“…Our Yps LFI was also tested with Y. similis and Y. wautersii, two species that were recently described and are closely related to Y. pseudotuberculosis and (in the case of Y. wautersii) presumably pathogenic for human (46,47), and gave negative results.…”

Section: Discussionmentioning

confidence: 99%

Fast and Sensitive Detection of Enteropathogenic Yersinia by Immunoassays

et al. 2015

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Yersinia enterocolitica and Yersinia pseudotuberculosis, the two Yersinia species that are enteropathogenic for humans, are distributed worldwide and frequently cause diarrhea in inhabitants of temperate and cold countries. Y. enterocolitica is a major cause of foodborne disease resulting from consumption of contaminated pork meat and is further associated with substantial economic cost. However, investigation of enteropathogenic Yersinia species is infrequently performed routinely in clinical laboratories because of their specific growth characteristics, which make difficult their isolation from stool samples. Moreover, current isolation procedures are time-consuming and expensive, thus leading to underestimates of the incidence of enteric yersiniosis, inappropriate prescriptions of antibiotic treatments, and unnecessary appendectomies. The main objective of the study was to develop fast, sensitive, specific, and easy-to-use immunoassays, useful for both human and veterinary diagnosis. T he genus Yersinia belongs to the family of Enterobacteriaceae and is composed of three human-pathogenic species: Yersinia pestis, the causative agent of the plague, and Yersinia enterocolitica and Y. pseudotuberculosis, responsible for human enteric yersiniosis. Enteric yersiniosis is a foodborne disease caused by consumption of contaminated food or water (1) and can be transmitted between humans through the fecal-oral route. The disease is usually characterized by a self-limiting acute infection beginning in the intestine and is often limited to the ileocecal junction for Y. enterocolitica. In contrast, Y. pseudotuberculosis often disseminates deeply to the mesenteric lymph nodes. Clinical presentation is characterized by enterocolitis (diarrhea, abdominal pain, fever, and sometimes vomiting) (2), which predominates in young children and is often self-limiting. However, diarrhea is a predominant symptom of Y. enterocolitica infection whereas abdominal pain is more usual in Y. pseudotuberculosis infection. Moreover, Y. pseudotuberculosis can also cause different clinical symptoms such as scarlatinoid rash, conjunctivitis, acute organ failure, and toxic shock syndrome often reported in Far East (3). For both enteropathogenic Yersinia species, more-serious infections and sepsis can also occur, particularly in new-born, elderly, and immunocompromised patients. Sometimes, the infection appears as a pseudoappendicular syndrome in which mesenteric lymph nodes are involved, thus possibly leading to unnecessary appendectomies (4). Some secondary complications such as reactive arthritis and erythema nodosum are sometimes observed (5, 6). Rarely, Y. enterocolitica is responsible for a serious sepsis incident after transfusion of contaminated red blood cell preparations (7).Y. enterocolitica and Y. pseudotuberculosis are widespread worldwide, with a higher incidence in cold and temperate regions. pseudotuberculosis serotypes I and III are the prevailing isolated strains (9). The incidence of human enteric yersiniosis has been estimated to...

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Section: Discussionmentioning

confidence: 99%

Fast and Sensitive Detection of Enteropathogenic Yersinia by Immunoassays

et al. 2015

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“…2008) and the newly characterised Y. wautersii (previously referred to as the ‘Korean group’) that is proposed to have pathogenic potential (Savin et al . 2014). …”

Section: Biology Of the Genus Yersiniamentioning

confidence: 99%

“…2011; Savin et al . 2014), which led to the proposal that the O-antigen serotyping scheme should apply to all members of this complex (Laukkanen-Ninios et al . 2011; De Castro et al .…”

Section: O Serotypes In the Yersinia Pseudotuberculosis Complexmentioning

confidence: 99%

Genetics and evolution of Yersinia pseudotuberculosis O-specific polysaccharides: a novel pattern of O-antigen diversity

Kenyon

Cunneen

Reeves

2017

FEMS Microbiology Reviews

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O-antigen polysaccharide is a major immunogenic feature of the lipopolysaccharide of Gram-negative bacteria, and most species produce a large variety of forms that differ substantially from one another. There are 18 known O-antigen forms in the Yersinia pseudotuberculosis complex, which are typical in being composed of multiple copies of a short oligosaccharide called an O unit. The O-antigen gene clusters are located between the hemH and gsk genes, and are atypical as 15 of them are closely related, each having one of five downstream gene modules for alternative main-chain synthesis, and one of seven upstream modules for alternative side-branch sugar synthesis. As a result, many of the genes are in more than one gene cluster. The gene order in each module is such that, in general, the earlier a gene product functions in O-unit synthesis, the closer the gene is to the 5΄ end for side-branch modules or the 3΄ end for main-chain modules. We propose a model whereby natural selection could generate the observed pattern in gene order, a pattern that has also been observed in other species.

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“…Although this strain has been isolated in Sweden, it was shown to carry several genes found in Russian isolates that cause a specific and severe disease known as Far East scarlet-like fever (4). We initially thought that this strain was a Y. pseudotuberculosis isolate; however, recent phenotypic and genetic characterization of Korean group strains indicate that this group forms a new and potentially pathogenic species of Yersinia named Yersinia wautersii (42). Our results thus suggest that IS-RFLP might also have the power to differentiate closely related but distinct species within the Y. pseudotuberculosis complex.…”

Section: Discussionmentioning

confidence: 79%