The Wnt signaling pathway and rheumatoid arthritis

Rabelo, Francieli de Sousa; Mota, Lícia Maria Henrique da; Lima, Rodrigo Aires Corrêa; Lima, Francisco Aires Corrêa; Barra, Gustavo Barcelos; Carvalho, Jozélio Freire de; Amato, Angélica Amorim

doi:10.1016/j.autrev.2009.08.003

Cited by 64 publications

(27 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with RA, the synovial membrane expresses higher levels of Wnt and Fz than it does in patients without RA. In activated state, the Wnt proteins bind to the receptors of the Fz proteins on the cell surface, and the Wnt/Fz complex controls tissue formation during embryogenesis, joint formation and limb development [34]. There is evidence that Wnt1 is overexpressed in RA patients, stimulating the production of fibronectin and pro-MMP-3 [35].…”

Section: Discussionmentioning

confidence: 98%

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts

et al. 2015

View full text Add to dashboard Cite

“…Alterations or defects in the LRP5 and LRP6-mediated signaling pathway are associated with several human inflammatory diseases(11, 12). Interestingly, increased wnt ligand expression is observed in several inflammatory diseases (13–17). Although DCs are present in low number in the CNS under homeostatic conditions, their numbers increase drastically during autoimmune inflammation, infection or trauma(18).…”

Section: Introductionmentioning

confidence: 99%

Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation

Suryawanshi

Manoharan

Yuan

et al. 2015

The Journal of Immunology

115

View full text Add to dashboard Cite

Breakdown in immunological tolerance to self-antigens or uncontrolled inflammation results in autoimmune disorders. Dendritic cells (DCs) play an important role in regulating the balance between inflammatory and regulatory responses in the periphery. However, factors in the tissue microenvironment and the signaling networks critical for programming DCs to control chronic inflammation and promote tolerance are unknown. Here, we show that wnt ligand-mediated activation of β-catenin signaling in DCs is critical for promoting tolerance and limiting neuroinflammation. DC-specific deletion of key upstream (LRP5/6) or downstream mediators (β-catenin) of canonical wnt-signaling in mice exacerbated experimental autoimmune encephalomyelitis (EAE) pathology. Mechanistically, loss of LRP5/6-β-catenin-mediated signaling in DCs led to an increased Th1/ Th17 cell differentiation whereas reduced regulatory T cell response. This was due to increased production of pro-inflammatory cytokines and decreased production of anti-inflammatory cytokines such as IL-10 and IL-27 by DCs lacking LRP5/6-β-catenin signaling. Consistent with these findings, pharmacological activation of canonical wnt/β-catenin signaling delayed EAE onset and diminished CNS pathology. Thus, the activation of canonical wnt signaling in DCs limits effector T cell responses and represents a potential therapeutic approach to control autoimmune neuroinflammation.

show abstract

“…The Wnt signalling pathway is thought to play an important role in the regulation of bone remodelling, promoting the differentiation of mesenchymal progenitors into osteoblasts and inhibiting the formation of osteoclasts (2)(3)(4). Thus, research interest concerning Wnt signalling regulators in inflammatory arthropathy has increased.…”

mentioning

confidence: 97%

The association of radiographic progression with serum R-spondin 1 (RSPO1) levels or Dickkopf-1 (DKK1)/RSPO1 ratios in rheumatoid arthritis patients: clinical evidence for reciprocal inhibition between DKK1 and RSPO1

Choi

Chang

Cho

et al. 2014

Scandinavian Journal of Rheumatology

View full text Add to dashboard Cite

show abstract

The Wnt signaling pathway and rheumatoid arthritis

Cited by 64 publications

References 34 publications

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts

Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation

The association of radiographic progression with serum R-spondin 1 (RSPO1) levels or Dickkopf-1 (DKK1)/RSPO1 ratios in rheumatoid arthritis patients: clinical evidence for reciprocal inhibition between DKK1 and RSPO1

Contact Info

Product

Resources

About