The association of radiographic progression with serum R-spondin 1 (RSPO1) levels or Dickkopf-1 (DKK1)/RSPO1 ratios in rheumatoid arthritis patients: clinical evidence for reciprocal inhibition between DKK1 and RSPO1

Choi, Byung-Se; Chang, Song Ho; Cho, H J; Kang, Eun Ha; Shin, Kichul; Song, Yeong Wook; Lee, Y J

doi:10.3109/03009742.2014.905629

Cited by 6 publications

(2 citation statements)

References 34 publications

(57 reference statements)

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“…As a result, it was concluded that RSPO1 had therapeutic potential as an anabolic agent in arthritis. Another study reported significantly lower serum RSPO1 concentrations in rheumatoid arthritis patients compared to matched controls, and anti-TNF-α therapy significantly increased serum RSPO1 levels (33). The current study found a positive correlation between RSPO1 levels and TNF-α levels.…”

Section: Discussionsupporting

confidence: 67%

R-Spondin1 and tumor necrosis factor-alpha in infertile women with polycystic ovary syndrome: relationships with insulin resistance and other parameters

Gürbüz¹,

Gökmen²,

MADENLİ>

et al. 2023

Journal of Health Sciences and Medicine

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Aim: To evaluate the relationship between R-spondin1 (RSPO1) and Tumor Necrosis Factor-Alpha (TNF-α) levels with insulin resistance (IR) and other parameters in infertile women with polycystic ovary syndrome (PCOS). Material and Method: This case-control prospective observational study was carried out on 84 patients admitted to the University of Health Sciences Etlik Zübeyde Hanım Training and Research Hospital Gynecology and IVF Clinic and Medistate Hospital Gynecology and IVF Clinic between September 2020 and June 2021. Women aged 18-36 years diagnosed with infertility and PCOS constituted the PCOS group. Women who were diagnosed with infertility but not PCOS formed the control group. Cases were divided according to their body mass index (BMI) values into obese (BMI≥25) and non-obese (BMI

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Section: Discussionsupporting

confidence: 67%

R-Spondin1 and tumor necrosis factor-alpha in infertile women with polycystic ovary syndrome: relationships with insulin resistance and other parameters

Gürbüz¹,

Gökmen²,

MADENLİ>

et al. 2023

Journal of Health Sciences and Medicine

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“… 17 34 More recently, a relative reduction of serum levels of DKK1 was documented after treatment with anti-TNF. 39 …”

Section: Tnf Inhibition and Systemic Bone Lossmentioning

confidence: 99%

Bone and TNF in rheumatoid arthritis: clinical implications

Manara

Sinigaglia

2015

RMD Open

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Experimental data have demonstrated that tumour necrosis factor (TNF) plays a significant role in systemic and local bone loss related to rheumatoid arthritis (RA). In clinical studies on patients with RA, treatment with TNF inhibitors was able to arrest systemic bone loss assessed by bone mineral density and bone turnover markers, but there is scarce evidence of a clinically meaningful effect of TNF inhibition in preventing fractures. TNF inhibitors showed a higher efficacy in reducing radiographic progression related to the disease compared to methotrexate in randomised clinical trials. Data from observational studies seem to confirm the effectiveness of anti-TNF therapy in reducing joint damage evolution.

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The serum level of Dickkopf-1 in patients with rheumatoid arthritis: A systematic review and meta-analysis

Zhang

Wang

et al. 2018

International Immunopharmacology

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The association of radiographic progression with serum R-spondin 1 (RSPO1) levels or Dickkopf-1 (DKK1)/RSPO1 ratios in rheumatoid arthritis patients: clinical evidence for reciprocal inhibition between DKK1 and RSPO1

Abstract: In this study, the presence of RSPO1 in the circulation was shown for the first time. Our results suggest that the serum DKK1/RSPO1 ratio represents a better predictor of structural progression than either DKK1 or RSPO1 levels alone in RA patients.

Cited by 6 publications

References 34 publications

R-Spondin1 and tumor necrosis factor-alpha in infertile women with polycystic ovary syndrome: relationships with insulin resistance and other parameters

R-Spondin1 and tumor necrosis factor-alpha in infertile women with polycystic ovary syndrome: relationships with insulin resistance and other parameters

Bone and TNF in rheumatoid arthritis: clinical implications

The serum level of Dickkopf-1 in patients with rheumatoid arthritis: A systematic review and meta-analysis

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