“…In addition, T-type channels generate "window currents," in which, at certain potentials, a proportion of channels are open but not inactivated, leading to an inward calcium current, which contributes to membrane stability. It follows that changes in the channel milieu, which determine whether channels are open, closed, or inactivated, will influence the window current, which, in turn, will have consequences on neuronal excitability, a chain of events that may underlie seizure initiation (Williams et al 1997;Perez-Reyes 2003;Crunelli et al 2005;Contreras 2006;Cain and Snutch 2010). Finally, T-type channels also influence neuronal firing in a calcium-dependent manner by controlling intracellular calcium concentration and interacting with calcium-activated potassium channels (Simms and Zamponi 2014).…”