The WHO Pandemic Influenza Preparedness Framework

Fidler, David P.; Gostin, Lawrence O.

doi:10.1001/jama.2011.960

Cited by 67 publications

(28 citation statements)

References 3 publications

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“…Pandemic influenzas have even more profound mortality impacts, with more than 50 million influenza-related deaths reported in 1918–9 [6]. The ongoing susceptibility of populations to pandemic influenza was emphasized by the rapid international spread of swine-origin H1N1 influenza in 2009 [7], [8], [9]. Further, the anticipated human-to-human transmission of avian-origin H5N1 influenza, which has already claimed 335 lives worldwide (www.who.int/csr/disease/avian_influenza/) by zoonotic transmission, serves as an obvious indicator of the persisting risk of pandemics [9], [10].…”

Section: Introductionmentioning

confidence: 99%

Synergistic TLR2/6 and TLR9 Activation Protects Mice against Lethal Influenza Pneumonia

et al. 2012

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Lower respiratory tract infections caused by influenza A continue to exact unacceptable worldwide mortality, and recent epidemics have emphasized the importance of preventative and containment strategies. We have previously reported that induction of the lungs' intrinsic defenses by aerosolized treatments can protect mice against otherwise lethal challenges with influenza A virus. More recently, we identified a combination of Toll like receptor (TLR) agonists that can be aerosolized to protect mice against bacterial pneumonia. Here, we tested whether this combination of synthetic TLR agonists could enhance the survival of mice infected with influenza A/HK/8/68 (H3N2) or A/California/04/2009 (H1N1) influenza A viruses. We report that the TLR treatment enhanced survival whether given before or after the infectious challenge, and that protection tended to correlate with reductions in viral titer 4 d after infection. Surprisingly, protection was not associated with induction of interferon gene expression. Together, these studies suggest that synergistic TLR interactions can protect against influenza virus infections by mechanisms that may provide the basis for novel therapeutics.

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Section: Introductionmentioning

confidence: 99%

Synergistic TLR2/6 and TLR9 Activation Protects Mice against Lethal Influenza Pneumonia

et al. 2012

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“…Fundamental structural barriers embedded in public health governance systems arise as the result of lack of trust (Pisani and AbouZahr, 2010; Fidler and Gostin, 2011; van Panhuis et al, 2014). Perceptions of risk to patient privacy and intellectual property, as well as the fear of misinterpretation and potential misuse of data are some of the biggest challenges to the sharing of sequence data and the exchange of contextual information (van Panhuis et al, 2014).…”

Section: Barriers To Integration and Sharing Of Whole Genome Sequencementioning

confidence: 99%

Context Is Everything: Harmonization of Critical Food Microbiology Descriptors and Metadata for Improved Food Safety and Surveillance

et al. 2017

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Globalization of food networks increases opportunities for the spread of foodborne pathogens beyond borders and jurisdictions. High resolution whole-genome sequencing (WGS) subtyping of pathogens promises to vastly improve our ability to track and control foodborne disease, but to do so it must be combined with epidemiological, clinical, laboratory and other health care data (called “contextual data”) to be meaningfully interpreted for regulatory and health interventions, outbreak investigation, and risk assessment. However, current multi-jurisdictional pathogen surveillance and investigation efforts are complicated by time-consuming data re-entry, curation and integration of contextual information owing to a lack of interoperable standards and inconsistent reporting. A solution to these challenges is the use of ‘ontologies’ - hierarchies of well-defined and standardized vocabularies interconnected by logical relationships. Terms are specified by universal IDs enabling integration into highly regulated areas and multi-sector sharing (e.g., food and water microbiology with the veterinary sector). Institution-specific terms can be mapped to a given standard at different levels of granularity, maximizing comparability of contextual information according to jurisdictional policies. Fit-for-purpose ontologies provide contextual information with the auditability required for food safety laboratory accreditation. Our research efforts include the development of a Genomic Epidemiology Ontology (GenEpiO), and Food Ontology (FoodOn) that harmonize important laboratory, clinical and epidemiological data fields, as well as existing food resources. These efforts are supported by a global consortium of researchers and stakeholders worldwide. Since foodborne diseases do not respect international borders, uptake of such vocabularies will be crucial for multi-jurisdictional interpretation of WGS results and data sharing.

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“…HPAI viruses that cause human infections are available to the global animal and public health sectors under the terms of the WHO Pandemic Influenza Preparedness Framework (Fidler and Gostin 2011;WHO 2009c …”

Section: Databases Bioinformatics and Related Toolsmentioning

confidence: 99%

Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses

Donis

2014

Influenza Pathogenesis and Control - Volume I

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In response to the ongoing threat to animal and human health posed by HPAI endemic in poultry, Asia (H5N1) and North America (H7N3) have revived efforts to reduce pandemic risk by disease control at the source and improved pandemic vaccines. Discovery of conserved neutralization epitopes in the HA, which mediate broad protection within and across HA subtypes have changed the paradigm of "broadly reactive" or "universal" vaccine design. Development of such vaccines would benefit from comparative antigenic analysis of viruses with increasing divergence within (and between) HA subtypes. A review of recent work to define the antigenic properties of HPAI viruses revealed data generated through an array of experimental approaches. This information has supported diagnostics and vaccine development for animal and human health. Further harmonization of analytical methods is needed to determine the antigenic relationships among multiple lineages of rapidly evolving HPAI viruses.

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The WHO Pandemic Influenza Preparedness Framework

Cited by 67 publications

References 3 publications

Synergistic TLR2/6 and TLR9 Activation Protects Mice against Lethal Influenza Pneumonia

Synergistic TLR2/6 and TLR9 Activation Protects Mice against Lethal Influenza Pneumonia

Context Is Everything: Harmonization of Critical Food Microbiology Descriptors and Metadata for Improved Food Safety and Surveillance

Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses

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