Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses

Donis, Ruben O.

doi:10.1007/82_2014_422

Cited by 4 publications

(3 citation statements)

References 186 publications

(169 reference statements)

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“…Currently, there is no universal vaccine against AIVs for poultry [46]. A comprehensive compilation of seed strains or subunit sources has previously been evaluated [47,48]. AIV is a non-eradicable zoonosis due to rapid antigenic drift and multiple virus reservoirs in wildlife [49].…”

Section: Conventional Aiv Vaccines Of Poultrymentioning

confidence: 99%

Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Rajamanonmani

Chan

Prabakaran

2022

Viruses

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The poultry industry is the largest source of meat and eggs for human consumption worldwide. However, viral outbreaks in farmed stock are a common occurrence and a major source of concern for the industry. Mortality and morbidity resulting from an outbreak can cause significant economic losses with subsequent detrimental impacts on the global food supply chain. Mass vaccination is one of the main strategies for controlling and preventing viral infection in poultry. The development of broadly protective vaccines against avian viral diseases will alleviate selection pressure on field virus strains and simplify vaccination regimens for commercial farms with overall savings in husbandry costs. With the increasing number of emerging and re-emerging viral infectious diseases in the poultry industry, there is an urgent need to understand the strategies for broadening the protective efficacy of the vaccines against distinct viral strains. The current review provides an overview of viral vaccines and vaccination regimens available for common avian viral infections, and strategies for developing safer and more efficacious viral vaccines for poultry.

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Section: Conventional Aiv Vaccines Of Poultrymentioning

confidence: 99%

Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Rajamanonmani

Chan

Prabakaran

2022

Viruses

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“…There is also significant performance variability between laboratories due to multi-step signal amplification or reliance on experienced operators. Given these inevitable limitations of the current MN assay, there is a need to transform the MN assay to be safe, high-throughput, robust, easy to standardize, and automation compatible( 15 ).…”

Section: Introductionmentioning

confidence: 99%

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

Creanga

Gillespie

Fisher

et al. 2020

Preprint

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A number of broadly neutralizing antibodies (bnAbs) to influenza virus have been isolated, characterized and developed as potential countermeasures for seasonal influenza epidemic and pandemic. Deep characterization of these bnAbs and polyclonal sera is critical to our understanding of influenza immunity and for desgining universal influenza vaccines. However, conventional influenza virus neutralization assays with live viruses require high-containment laboratories and are difficult to standardize and roboticize. Here, we built a panel of engineered influenza viruses carrying a fluorescent reporter gene to replace an essential viral gene. This restricts virus replication to cells expressing the missing viral gene in trans, allowing it to be manipulated in a biosafety level 2 environment. Using this system, we characterize the neutralization profile of a set of published and new bnAbs with a panel consisting of 55 viruses that spans the near complete antigenic evolution of human H1N1 and H3N2 viruses, as well as pandemic viruses such as H5N1 and H7N9. Our system opens opportunities to systematically characterize influenza immunity in greater depth, including the response directed at the viral hemagglutinin stem, a major target of universal influenza vaccines.

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“…The emergence and spread of highly pathogenic avian in uenza (HPAI) A (H5N1) viruses have fueled concerns of a potential zoonotic poultry pandemic [1], and spurred efforts towards developing vaccines against A (H5N1) in uenza viruses, as well as improving vaccine production methods [2]. Current licensed vaccines including adjuvanted formulation are predominately inactivated whole avian in uenza H5N1, and have been available for the control of outbreaks in poultry [3].…”

Section: Introductionmentioning

confidence: 99%

High immune efficacy against different avian influenza H5N1 viruses by oral administration of a Saccharomyces cerevisiae-based vaccine in chickens

Han

Cen

Gao

et al. 2020

Preprint

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BackgroundA safe and effective vaccine is the best way to control large-scale highly pathogenic avian influenza virus (HPAI) A (H5N1) outbreaks. Saccharomyces cerevisiae (S. cerevisiae) is an ideal mucosal delivery vector for vaccine development, and we have previously shown that conventional injection administration with a S. cerevisiae-based vaccine (EBY100/pYD1-HA) was protective against homologous H5N1 virus in a mouse model. Due to the diameter of S. cerevisiae is around 10 μm which results in a severe inflammation by injection route, therefore, oral administration is a more suitable approach for EBY100/pYD1-HA conferring cross-protection in poultry. ResultsWe extended our work by evaluating the immunogenicity and cross-protective efficacy of oral vaccination with EBY100/pYD1-HA in the chicken model. Oral immunization with EBY100/pYD1-HA could induce robust serum IgG, mucosal IgA and cellular immune responses. Importantly, EBY100/pYD1-HA provided complete cross-protection against different H5N1 viruses challenge. ConclusionsThese findings suggest EBY100/pYD1-HA, a promising H5N1 oral vaccine candidate, can avoid potential reassortment of other avian influenza viruses in oral administration of live virus vaccines and overcome the drawbacks of conventional injection route. Importantly, this platform will be able to provide opportunities for broader applications in poultry during HPAI A (H5N1) outbreaks.

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Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses

Cited by 4 publications

References 186 publications

Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

High immune efficacy against different avian influenza H5N1 viruses by oral administration of a Saccharomyces cerevisiae-based vaccine in chickens

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