Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Rajamanonmani, Ravikumar; Chan, Janlin; Prabakaran, Mookkan

doi:10.3390/v14061195

“…In IBV, suboptimal vaccination alters the evolutionary dynamics of the viruses and can contribute to the production of escape mutants [122][123][124]. Finding broadly neutralizing IBV vaccines remains a significant challenge for the poultry industry [125][126][127][128][129].…”

Section: Harms Of Coronavirus Vaccinationmentioning

confidence: 99%

The Novelty of mRNA Vaccines and Potential Harms: A Scoping Review

Halma¹,

Rose²,

Lawrie³

2023

Preprint

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Pharmacovigilance databases are showing evidence of injury in the context of the COVID-19 modified mRNA shots. According to recent publications, adverse event reports linked to the mRNA COVID-19 products largely point to the spike protein as an aetiological agent of adverse events, but we propose that the platform itself may be culpable. To assess the safety of current and future mRNA vaccines, further analysis on the risks due to the platform itself, and not specifically the expressed antigen. If harm can be exclusively and conclusively attributed to the spike protein, then it is possible that future mRNA vaccines expressing other antigens will be safe. If harms are attributable to the platform itself, then regardless of the toxicity, or lack thereof, of the chosen payload therein, the platform may be inherently unsafe, pending modification. In this work, we examine previous studies of RNA-based delivery by a lipid nanoparticle and break down the possible etiological elements of harm.

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“…In IBV, suboptimal vaccination alters the evolutionary dynamics of the viruses and can contribute to the production of escape mutants [89][90][91]. Finding broadly neutralizing IBV vaccines remains a significant challenge for the poultry industry [92][93][94][95][96].Other, more distantly related coronaviruses have veterinary vaccines available. These have been summarized in a recent review [83].…”

Section: Harms Of Coronavirus Vaccinationmentioning

confidence: 99%

The Novelty of mRNA Vaccines and Potential Harms: A Scoping Review

Halma¹,

Rose²,

Jenks³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Pharmacovigilance databases are showing evidence of injury in the context of the COVID-19 modified mRNA shots. According to recent publications, adverse event reports linked to the mRNA COVID-19 products largely point to the spike protein as an aetiological agent of adverse events, but we propose that the platform itself may be culpable. To assess the safety of current and future mRNA vaccines, further analysis on the risks due to the platform itself, and not specifically the expressed antigen. If harm can be exclusively and conclusively attributed to the spike protein, then it is possible that future mRNA vaccines expressing other antigens will be safe. If harms are attributable to the platform itself, then regardless of the toxicity, or lack thereof, of the chosen payload therein, the platform may be inherently unsafe, pending modification. In this work, we examine previous studies of RNA-based delivery by a lipid nanoparticle and break down the possible etiological elements of harm.

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“…Therefore, bird treatment schemes in poultry farms mostly constitute programs or technological maps of vaccination. 185 Each poultry farm has its own technology for the specific prevention of infectious diseases. Following the technology allows to achieve a full immune response, suppress subclinical disease course, reduce the incidence of secondary infections and minimize the use of veterinary drugs for therapeutic and prophylactic purposes.…”

Section: Measures To Control and Prevent The Infectious Diseases Of B...mentioning

confidence: 99%

Potential Role of Intensive Bird Growing during Outbreaks of Viral Zoonosis in Ukraine, Russian Federation, Kazakhstan and Belarus (on the Model Viruses Highly Pathogenic Influenza and Newcastle Diseases): Systematic Review

Chechet¹,

Kornienko²,

Ukhovskyi³

et al. 2022

J. Pure Appl. Microbiol.

0

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The paper highlights the impact of two cross-border poultry infections with zoonotic potential (avian flu and Newcastle disease) on the functioning of industrial poultry farms in the former Soviet Union counties (Ukraine, Russia, Belarus, Kazakhstan), where the poultry industry is fairly well-developed. Despite the permanent vaccination of poultry against Newcastle disease in industrial poultry farming, the disease still affects individual farms in Ukraine, the Russian Federation, and Kazakhstan. In case of outbreaks, the Russian Federation and Kazakhstan use inactivated influenza vaccines. In Ukraine, for almost 20 years, outbreaks of influenza have been confirmed mainly on individual farms, and one outbreak of highly pathogenic influenza was reported on an industrial poultry farm in 2020. In the Russian Federation, highly pathogenic influenza occurs on industrial poultry farms more often. In Russia, seven industrial poultry enterprises were affected by influenza in 2016-2017, and eight in 2018. Infection of poultry with influenza virus on poultry factory farms is an indication of shortcomings in compliance with biosecurity measures. Influenza and Newcastle disease are always likely to occur in the countries in question, as wild birds migrate through their territory, and they are a reservoir of pathogens, therefore outbreaks are often associated with spring and autumn migrations of wild birds. In all of said countries, a large number of poultry is kept by individual households, where basic biosecurity, sanitation and preventive vaccination measures are not applied. This component is often crucial in bringing viral infections such as influenza and Newcastle disease on large poultry farms. As a result, the virus is brought onto poultry farms by synanthropic birds, humans, transport, feed, etc.

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Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy

Cited by 31 publications

References 188 publications

The Novelty of mRNA Vaccines and Potential Harms: A Scoping Review

The Novelty of mRNA Vaccines and Potential Harms: A Scoping Review

The Novelty of mRNA Vaccines and Potential Harms: A Scoping Review

Potential Role of Intensive Bird Growing during Outbreaks of Viral Zoonosis in Ukraine, Russian Federation, Kazakhstan and Belarus (on the Model Viruses Highly Pathogenic Influenza and Newcastle Diseases): Systematic Review

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