SummaryMore than 100 hydropower dams have already been built in the Amazon basin and numerous proposals for further dam constructions are under consideration. The accumulated negative environmental effects of built and proposed dams, if constructed, will trigger massive hydrophysical and biotic disturbances that will impact the Amazon basin's floodplains, estuary, and sediment plume. By introducing a Dam Environmental Vulnerability Index (DEVI) we quantify the current and potential impacts of dams in the basin. The scale of foreseeable environmental degradation indicates the need for collective action among nations and states to avoid cumulative, far-field impacts. We suggest institutional innovations to assess and avoid the likely impoverishment of Amazon rivers.