The volatile anesthetic sevoflurane mitigates cardiodepressive effects of platelets in reperfused hearts

Abstract

1) Pretreatment of hearts with sevoflurane reduces intracoronary platelet adhesion, most likely via an endothelial mechanism. 2) Pretreatment of platelets with sevoflurane does not reduce platelet adhesion, but nevertheless averts cardiodepressive effects derived from or generated by adherent platelets. 3) Transudate formation of hearts during reperfusion was reduced after platelet application, independent of the adherence of platelets.

Myocardial protection by anesthetic agents against ischemia-reperfusion injury: An update for anesthesiologists

“…57 These studies imply that halogenated anesthetics can act directly on neutrophils at the time of reperfusion. Volatile anesthetics also reduced platelet adhesion to the vascular wall after ischemia, 45,47 but sevoflurane failed to reduce the expression of glycoprotein IIb/IIIa, a platelet adhesion molecule involved in the platelet-endothelium interaction. 47 Another possibility of coronary protection by halogenated anesthetics is via an ischemic preconditioning-like effect.…”

“…This anesthetic improves postischemic mechanical and coronary function, and reduces infarct size. 32,34,37,[45][46][47][48][49][50] A beneficial effect of desflurane was suggested by a few groups. 34,49,51 Further investigations are needed to determine the effect of desflurane in other experimental settings.…”

“…32,37 A similar effect was also shown for platelets. 45,47 Reduced neutrophil/platelet entrapment by anesthetics was accompanied by enhancement of postischemic mechanical function. 37,47 However, the effects of halogenated anesthetics on neutrophil/platelet sequestration have been studied by a limited number of research groups.…”

“…45,47 Reduced neutrophil/platelet entrapment by anesthetics was accompanied by enhancement of postischemic mechanical function. 37,47 However, the effects of halogenated anesthetics on neutrophil/platelet sequestration have been studied by a limited number of research groups. 32,37,45,47 Novalija and coworkers measured coronary flow changes in response to endothelial-dependent and independent vasodilators.…”

“…37,47 However, the effects of halogenated anesthetics on neutrophil/platelet sequestration have been studied by a limited number of research groups. 32,37,45,47 Novalija and coworkers measured coronary flow changes in response to endothelial-dependent and independent vasodilators. Sevoflurane preserved the reaction provoked by both types of vasodilators during the reperfusion period better than no treatment.…”