Effects of Anesthetics on Ischemia-reperfusion Injury of the Heart

Preckel, Benedikt; Schlack, W.

doi:10.1007/978-1-4757-5551-0_16

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…These values were significantly greater than those obtained from placebo hearts. Changes in biomechanical parameters during heart perfusion and after midazolam pre-medication -experimental pilot study perimental conditions in vitro and in vivo; cardioprotection against reperfusion damage was also maintained when the heart was already protected against ischaemic damage by cardioplegic solutions 12,13 . The benzodiazepines have hardly been investigated for myocardial protection.…”

Section: Discussionmentioning

confidence: 99%

Changes in Biomechanical Parameters During Heart Perfusion and After Midazolam Pre-Medication - Experimental Pilot Study

Bartošíková¹,

Nečas²,

Bartošík³

et al. 2008

BIOMED PAP

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Background:Midazolam is a frequently used benzodiazepine in anaesthesiology and intensive care. Aim: The aim of pilot study was to monitor its eff ect during heart perfusion in the laboratory rat. Methods: The same groups of animals (n = 10). The 1 st group was treated with midazolam in a dose of 0.5mg/kg i.p. The 2 nd group was a placebo. After i.p. administration of heparine injection of 500 IU dose, the hearts were excised and perfused (modifi ed Langendorf's method). Working schedule: stabilization/ischaemia/reperfusion proceed at intervals of 20/30/60 min. Monitored parameters in isolated heart: left ventricle pressure (LVP), end-diastolic pressure (LVEDP), contractility (+dP/dt max ).Results: The treated hearts showed improved postischemic recovery, reaching LVP values of 92 ± 6 % at the end of the reperfusion, placebo only 61 ± 7 %. In placebo hearts LVEDP rose from 10.0 ± 0.5 mmHg to 43 ± 4 mmHg after, in treated animals only about 25 mmHg. The treated hearts improved +dP/dt max recovery during reperfusion to 91 ± 8 %. These values were signifi cantly greater than those obtained from the placebo hearts.Conclusions: Positive changes in monitored parameters were found in this experimental pilot study. We conclude that the administration of midazolam in laboratory rats has a cardioprotective potential against ischemia-reperfusion induced injury.

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Section: Discussionmentioning

confidence: 99%

Changes in Biomechanical Parameters During Heart Perfusion and After Midazolam Pre-Medication - Experimental Pilot Study

Bartošíková¹,

Nečas²,

Bartošík³

et al. 2008

BIOMED PAP

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show abstract

“…Задача анестезиолога -по возможности снизить или предотвратить метаболические, функциональные и струк турные изменения, происходящие после восстановления коро нарной перфузии, при помощи модификации условий репер фузии. Защита от реперфузионного повреждения получила название посткондиционирования [50,51].…”

Section: защита от реперфузии: посткондиционированиеunclassified

Ischemic and Pharmacological Preconditioning (part 2)

Лихванцев¹,

Мороз²,

Гребенчиков³

et al. 2012

rmt

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Effects of Anesthetics on Ischemia-reperfusion Injury of the Heart

Cited by 2 publications

References 39 publications

Changes in Biomechanical Parameters During Heart Perfusion and After Midazolam Pre-Medication - Experimental Pilot Study

Changes in Biomechanical Parameters During Heart Perfusion and After Midazolam Pre-Medication - Experimental Pilot Study

Ischemic and Pharmacological Preconditioning (part 2)

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