The Vitamin “D‐bate”: What Vascular Risk in Geriatric Inpatients?

Abraham, P.; Cales, S.; Redureau, Elise; Fantino, Bruno; Decker, Laure de; Beauchet, Olivier; Annweiler, Cédric

doi:10.1111/j.1532-5415.2011.03513.x

Cited by 7 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus the onset of executive dysfunction primarily characterized by impairments of the mental flexibility in case of vitamin D deficiency may be explained by a dysfunction of the frontal-subcortical neuronal circuits, particularly of the dorsolateral circuit, resulting from the loss of vitamin D neuroprotective effects [2,3,4] and the promotion of stroke and leukoaraiosis in the subcortical and frontal structures, as reported in prior neuroimaging studies [6]. Chronic hypovitaminosis D is thought to be a cardiovascular risk factor [36] and to promote the onset of other vascular risk factors such as atherosclerosis, diabetes or hypertension [37], which are known to increase the risk of cerebrovascular disease and AD [6,38]. This may be especially true when hypovitaminosis D is deeper and installed for a longer time, as evidenced here by the finding of an association of executive dysfunction with vitamin D deficiency, but not with vitamin D insufficiency.…”

Section: Discussionmentioning

confidence: 85%

Hypovitaminosis D and Executive Dysfunction in Older Adults with Memory Complaint: A Memory Clinic-Based Study

Annweiler¹,

Maby

Meyerber

et al. 2013

Dement Geriatr Cogn Disord

Self Cite

View full text Add to dashboard Cite

Background: Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. Methods: One hundred Caucasian older community dwellers with memory complaint (mean, 71.02 ± 0.74 years; 52.0% female) were divided into 3 groups according to serum 25-hydroxyvitamin D (25-OHD) concentration (deficiency <25 nmol/l, insufficiency 25-50 nmol/l, sufficiency >50 nmol/l). Executive functions were assessed with error rates by executing the Trail Making Test-B (TMT-B) for mental flexibility, the N-Back Test for information updating, the Stroop Interference Test for cognitive inhibition, and the Go/No-Go score for motor inhibition. Age, gender, BMI, education level, number of morbidities, depressive symptoms, Mini-Mental State Examination score, calcemia, estimated glomerular filtration rate and season tested were considered as potential confounders. Results: Compared to participants with vitamin D insufficiency and sufficiency, those with vitamin D deficiency had a poorer TMT-B performance (p = 0.019 and p = 0.017, respectively) but similar N-Back (p = 0.175), Stroop (p = 0.135) and Go/No-Go (p = 0.224) scores. Cognitive performance did not differ between participants with insufficient and sufficient vitamin D levels. Vitamin D deficiency was associated with poorer performance on TMT-B (adjusted β = 1.48, p = 0.011), but not on N-Back (p = 0.665), Stroop (p = 0.817) or Go/No-Go (p = 0.971). Conclusion: Vitamin D deficiencywas associated with poorer mental flexibility among older community dwellers with memory complaint.

show abstract

Section: Discussionmentioning

confidence: 85%

Hypovitaminosis D and Executive Dysfunction in Older Adults with Memory Complaint: A Memory Clinic-Based Study

Annweiler¹,

Maby

Meyerber

et al. 2013

Dement Geriatr Cogn Disord

Self Cite

View full text Add to dashboard Cite

show abstract

“…The second scenario corresponds to an overall deterioration in A and B (e.g. vascular calcification and deterioration in cerebrovascular health following addition of vitamin D) . The third scenario corresponds to an improvement in A, but a deterioration in B (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the fourth scenario corresponds to an improvement in B accompanied by a deterioration in A (e.g. increased calcium absorption in the digestive tract following addition of vitamin D with a consequent ameliorative effect on secondary osteoporosis, but a deleterious effect on vascular calcification and cerebrovascular health) . Thus, due to the ubiquitous role of vitamin D, elucidating its cognitive effects is more complex than investigating only the cerebral actions, and future basic and clinical studies should take into account all the effects of vitamin D in the body, particularly with regard to morbidity burden.…”

Section: Discussionmentioning

confidence: 99%

‘Vitamin D and cognition in older adults’: updated international recommendations

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Specifically, a potential anti‐atherosclerotic activity of vitamin D has been highlighted, and hypovitaminosis D has been associated with a higher prevalence of peripheral arterial disease . Potential mechanisms for increased vascular disease risk include increased oxidative stress, lipid peroxidation, glucose intolerance and metabolic syndrome in the case of hypovitaminosis D . Moreover, hypovitaminosis D appears to be a contributing factor to hypertension , mainly by suppression of the renin‐angiotensin system expression in the juxtaglomerular apparatus .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and white matter abnormalities in older adults: a cross‐sectional neuroimaging study

Annweiler

Bartha

et al. 2014

Euro J of Neurology

View full text Add to dashboard Cite

Background and purpose: Morphological brain changes related to hypovitaminosis D have been poorly studied. In particular, the age-related decrease in vitamin D concentrations may explain the onset of white matter abnormalities (WMA) in older adults. Our objectives were (i) to investigate whether there was an association between serum 25-hydroxyvitamin D (25OHD) concentration and the grade of WMA in older adults and (ii) to determine whether the location of WMA was associated with 25OHD concentration. Methods: One hundred and thirty-three Caucasian older community-dwellers with no clinical hydrocephalus (mean 71.6 AE 5.6 years; 43.6% female) received a blood test and a magnetic resonance imaging scan of the brain. The grades of total, periventricular and deep WMA were scored using semiquantitative visual rating scales from T2-weighted fluid-attenuated inversion recovery images. The association of WMA with as-measured and deseasonalized 25OHD concentrations was evaluated with the following covariates: age, gender, body mass index, use of anti-vascular drugs, number of comorbidities, impaired mobility, education level, Mini-Mental State Examination score, medial temporal lobe atrophy, serum concentrations of calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate. Results: Both as-measured and deseasonalized serum 25OHD concentrations were found to be inversely associated with the grade of total WMA (adjusted b = À0.32, P = 0.027), specifically with periventricular WMA (adjusted b = À0.15, P = 0.009) but not with deep WMA (adjusted b = À0.12, P = 0.090). Similarly, participants with 25OHD concentration <75 nM had on average a 33% higher grade of periventricular WMA than those with 25OHD ≥75 nM (P = 0.024). No difference in average grade was found for deep WMA (P = 0.949). Conclusions: Lower serum 25OHD concentration was associated with higher grade of WMA, particularly periventricular WMA. These findings provide a scientific basis for vitamin D replacement trials.

show abstract

The Vitamin “D‐bate”: What Vascular Risk in Geriatric Inpatients?

Cited by 7 publications

References 8 publications

Hypovitaminosis D and Executive Dysfunction in Older Adults with Memory Complaint: A Memory Clinic-Based Study

Hypovitaminosis D and Executive Dysfunction in Older Adults with Memory Complaint: A Memory Clinic-Based Study

‘Vitamin D and cognition in older adults’: updated international recommendations

Vitamin D and white matter abnormalities in older adults: a cross‐sectional neuroimaging study

Contact Info

Product

Resources

About