‘Vitamin D and cognition in older adults’: updated international recommendations

Annweiler, Cédric; Dursun, Erdinç; Féron, François; Gezen-Ak, Duygu; Kalueff, Allan V.; Littlejohns, Thomas J.; Llewellyn, David J.; Millet, Pascal; Scott, Tammy; Tucker, Katherine L.; Yılmazer, Selma; Beauchet, Olivier

doi:10.1111/joim.12279

Cited by 142 publications

(142 citation statements)

References 73 publications

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“…Despite growing evidence on vitamin D effects in the brain [18,19], particularly on cognition [4], only a few studies have examined the impact of vitamin D insufficiency on brain structures and specifically on the skull [3]. To the best of our knowledge, only one observational study has previously explored the association of serum 25OHD concentration with the intracranial volume [5].…”

Section: Discussionmentioning

confidence: 97%

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Vitamin D-related changes in intracranial volume in older adults: A quantitative neuroimaging study

et al. 2015

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Section: Discussionmentioning

confidence: 97%

“…However at least 1 billion people have insufficient 25OHD concentrations worldwide [1], and older adults are at particular risk with prevalence between 40 and 90% [1]. Vitamin D insufficiency exposes older adults to various adverse health events [1,2], including brain changes, cognitive decline, Alzheimer disease and dementia [3,4].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D-related changes in intracranial volume in older adults: A quantitative neuroimaging study

et al. 2015

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“…Nevertheless, vitamin D implementation in clinical practice does not give univocal results. A 7-year follow-up study confirmed that a huger intake of vitamin D has been linked to a lower risk of developing AD in normal ageing women [214][215][216]. Some recent works put in evidence that the combined effect of vitamin D and docosahexaenoic acid can enhance the neural protection towards the different effects of beta amyloid deposition [217], and a 6-month trial determined that there are better, even limited effects, when memantine was prescribed in association with vitamin D, rather than alone in AD patients [218].…”

Section: Vitamin D Deficiency and Neurodegenerative Diseasesmentioning

confidence: 87%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

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“…Inadequate vitamin D intake, urban dwelling, female gender, winter season, age, and high parity were independent predictors of low vitamin D levels. 12 Lifestyle-related factors that alter the endogenous production of Vitamin D in the human body as a result of inadequate exogenous intake over a long period of time undermine the most relevant risk factors to ascertain the difference of magnitude effect and compare each one. Sun exposure, including its determinants: time of day, application of sunscreen, sunbathing, nature of work and residence, outdoor/physical activity, and clothing as cultural behavior are significant in assessing the magnitude of risks posed on developing Vitamin D deficiency.…”

Section: Discusionmentioning

confidence: 99%

Assessing the Magnitude and Effect of Various Risk Factors Associated with Vitamin D Deficiency among Females in the UAE

Alomar¹,

Khouri²

2015

JYP

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Aim:The aim of this research is to determine the incidence and risk of developing Vitamin D deficiency, specifically among females within a certain age range in the UAE. Materials and Methods: A cross-sectional, descriptive, and observational study to observe and record lifestyle and dietary risk factors and their frequency in the selected females' daily lives and routines. An online distributed questionnaire has been designed and distributed among women of Al Ain city in Abu Dhabi (UAE). Statistical Analysis: SPSS version 20 was used for data analysis and statistical testing. The significance was tested using Chi Square. Results: Among the 124 females, 35.5% were exposed to the sun between 10 am and 3 pm and 64.5% were not exposed. Yes, 70.2% No). A high degree of association with P-values of 0.007 Pearson Chi-Square for frequent use of Sun protection factor 15 and its effect on sun exposure being daily in an in doors work/education environment, and Pvalues of 0.046 and 0.028 corresponding to "usual" use of Sun protection factor 15 and "rare" use. Conclusion: Vitamin D deficiency is common among female women who live in the UAE; many factors contribute to this deficiency. More rigorous work is needed to encourage women to avoid some of these factors in order to promote health and prevent vitamin D deficiency related health problems.

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‘Vitamin D and cognition in older adults’: updated international recommendations

Cited by 142 publications

References 73 publications

Vitamin D-related changes in intracranial volume in older adults: A quantitative neuroimaging study

Vitamin D-related changes in intracranial volume in older adults: A quantitative neuroimaging study

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Assessing the Magnitude and Effect of Various Risk Factors Associated with Vitamin D Deficiency among Females in the UAE

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