The Vascular Anatomy of the Rat Cochlea

Hornstrand, Charlotte; Axelsson, A.; Vertes, D.

doi:10.3109/00016488009127102

Cited by 20 publications

(6 citation statements)

References 11 publications

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“…Within the developing sensory organ, their presence parallels changes in cochlear vascular supply. The premature organ of Corti is well supplied by a large blood vessel in the basilar membrane which may provide the major metabolic support associated with development (Hornstrand et al 1980). This vessel disappears as the organ of Corti matures and the cochlea detects airborne sound (Hornstrand et al 1980) and perhaps sound transduction processes are supported then by glucose and oxygen diVusion through the cochlear Xuids and supplemented by creatine-phosphate metabolism in the organ of Corti, especially for transient sound detection.…”

Section: Discussionmentioning

confidence: 99%

Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues

Wong

Velamoor

Skelton

et al. 2012

Histochem Cell Biol

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Physiological processes in the cochlea associated with sound transduction and maintenance of the unique electrochemical environment are metabolically demanding. Creatine maintains ATP homeostasis by providing high-energy phosphates for ATP regeneration which is catalyzed by creatine kinase (CK). Cellular uptake of creatine requires a specific high affinity sodium- and chloride-dependent creatine transporter (CRT). This study postulates that this CRT is developmentally regulated in the rat cochlea. CRT expression was measured by quantitative real-time RT-PCR and immunohistochemistry in the postnatal (P0-P14) and adult (P22-P56) rat cochlea. The maximum CRT expression was reached at the onset of hearing (P12), and this level was maintained through to adulthood. CRT immunoreactivity was strongest in the sensory inner hair cells, supporting cells and the spiral ganglion neurons. Cochlear distribution of the CK brain isoform (CKB) was also assessed by immunohistochemistry and compared with the distribution of CRT in the developing and adult cochlea. CKB was immunolocalized in the organ of Corti supporting cells, and the lateral wall tissues involved in K(+) cycling, including stria vascularis and spiral ligament fibrocytes. Similar to CRT, CKB reached peak expression after the onset of hearing. Differential spatial and temporal expression of CRT and CK in cochlear tissues during development may reflect differential requirements for creatine-phosphocreatine buffering to replenish ATP consumed during energy-dependent metabolic processes, especially around the period when the cochlea becomes responsive to airborne sound.

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Section: Discussionmentioning

confidence: 99%

Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues

Wong

Velamoor

Skelton

et al. 2012

Histochem Cell Biol

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“…He gave a detailed description of the vessels in the cochlea in man and guinea pig and was the first who observed the different vascular anatomy in the basal end of the cochlea. Hornstrand et al [9] described the vascular anatomy of the cochlea of the rat according to the technique of Axelsson [3], Nevertheless, these studies failed to show the overall three-dimensional picture of the cochlear microvasculature. Up until now this region has not been studied by means of microcorrosion casts and SEM.…”

Section: Discussionmentioning

confidence: 99%

Microvasculature of the Stria vascularis in the Round Window Area in the Rat

Tange¹,

Hodde

1985

ORL

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This paper reports the results of a scanning electron microscopy study of corrosion cast preparation of the vessels in the cochlea of the rat. This method confirms the general findings about the cochlear vascularization, but also gives the opportunity to study the detailed pattern of the vascular supply of the stria vascularis in the round window area. The basal end of the stria vascularis has a remarkably different vascular anatomy compared with the other areas of the cochlea. The possible role of the vessels in the round area is discussed.

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“…Normal blood supply to the cochlea is very important for establishing the endocochlear potential and sustaining production of endolymph (2,27,28). The inner ear pericytes are also structural and functional components of the microvasculature.…”

Section: Origin Of the Inner Ear Vasculaturementioning

confidence: 99%

“…A similar event was observed in the vessel of the basilar membrane in the rat cochlea. The vessel of the basilar membrane under the organ of Corti is much larger during embryonic life, in comparison with the adult life, which allows the presumption that it may be important for the development and the regeneration of the organ of Corti (28,52).…”

Section: Origin Of the Inner Ear Vasculaturementioning

confidence: 99%

The pericyte progenitors and the pericytes are the ancestors of the inner ear structures

Davidoff

2020

International Bulletin of Otorhinolaryngology

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This short scientific overview concerns the morpho-functional comparison between the omnipresent pericytes and the pericytes of the inner ear and, besides some characteristic features of the last, provides evidence that the otic pericytes are authentic part of the omnipresent pericyte (adult stem cell) population of the vertebrate organism. In the present review we offer evidences for a new hypothesis that the pericyte progenitors and the pericytes, as pluripotent epiblast derivatives, are the ancestors of the supporting and hair cells of the Corti organ, the cells of the vestibular (balance) organ and the neural elements of the inner ear in norm and experiment. The most important evidences for this statement provide results concerning: 1. the origin of the inner ear vasculature; 2. the close relationships of the pericytes with the microvasculature of the inner ear (periendothelial location in microvascular niches); 3.their importance for the blood-labyrinth barrier; 4. the events that accompany the origin of the inner ear sensory epithelia; 5. the authentic stem cell qualities of the pericytes allowing the production of cells and tissues characteristic for the three embryonal germ layers: ectoderm, mesoderm and endoderm (during embryogenesis, in the adult organisms and at experimental and pathological conditions), as well as 6. the remarkable pericyte plasticity and their involvement in the immune system.

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The Vascular Anatomy of the Rat Cochlea

Cited by 20 publications

References 11 publications

Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues

Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues

Microvasculature of the Stria vascularis in the Round Window Area in the Rat

The pericyte progenitors and the pericytes are the ancestors of the inner ear structures

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