The variances in histamine control skin-testing response between Asian/Pacific islanders and other racial groups

Chou, Vivian; Lee-Wong, Mary; Wong, Raúl Igor Corrada; Cohen, Hillel W.

doi:10.1016/j.jaci.2004.01.088

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Variability in this technique has been described that may impact the validity of pharmacodynamic assessments using this method. Studies have also described differences in histamine prick skin test results across different racial and ethnic groups 21 . It is plausible that this described difference may be due to operator error in accurately assessing erythema in varying skin tones.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have also described differences in histamine prick skin test results across different racial and ethnic groups. 21 It is plausible that this described difference may be due to operator error in accurately assessing erythema in varying skin tones. Similar errors related to the ability to perceive erythema or other skin changes in darker skin tones have been described across various dermatologic conditions and states (e.g., eczema, infectious skin rashes, psoriasis).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker

Ramprasad,

Ezekwe,

Lee

et al. 2024

Clinical Translational Sci

View full text Add to dashboard Cite

The phenotypical manifestations of asthma among children are diverse and exhibit varying responses to therapeutic interventions. There is a need to develop objective biomarkers to improve the characterization of allergic and inflammatory responses relevant to asthma to predict therapeutic treatment responses. We have previously investigated histamine iontophoresis with laser Doppler flowmetry (HILD) as a potential surrogate biomarker that characterizes histamine response and may be utilized to guide the treatment of allergic and inflammatory disease. We have identified intra‐individual variability of HILD response type among children and adults with asthma and that HILD response type varied in association with racial classification. As laser Doppler flowimetry may be impacted by skin color, we aimed to further validate the HILD method by determining if skin color or tone is associated with observed HILD response type differences. We conducted an observational study utilizing quantification of skin color and tone obtained from photographs of the skin among participants during HILD assessments via the RGB color model. We compared RGB values across racial, ethnic, and HILD response type via the Kruskal‐Wallis test and calculated Kendall rank correlation coefficient to evaluate the relationship between RGB composite scores and HILD pharmacodynamic measures. We observed that RGB scores differed among racial groups and histamine response phenotypes (p < 0.05). However, there was a lack of correlation between the RGB composite score and HILD pharmacodynamic measures (r values 0.1, p > 0.05). These findings suggest that skin color may not impact HILD response variations, necessitating further research to understand previously observed differences across identified racial groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker

Ramprasad,

Ezekwe,

Lee

et al. 2024

Clinical Translational Sci

View full text Add to dashboard Cite

show abstract

“…This finding has indeed opened up new avenues to deduce the physiology and pathophysiology of histaminergic receptors in relation to skin pigmentation. Also recently, Chou et al [167] investigated the variances in the histamine control skin-testing response between Asian/Pacific islanders and other racial groups. It was found that Asian-Americans did not have a statistically significant difference in the histamine skin test when compared to Hispanic-Americans and caucasians.…”

Section: The Pharmacology Of Histamine Receptorsmentioning

confidence: 99%

Vertebrate melanophores as potential model for drug discovery and development: A review

Salim¹,

Ali²

2011

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

Drug discovery in skin pharmacotherapy is an enormous, continually expanding field. Researchers are developing novel and sensitive pharmaceutical products and drugs that target specific receptors to elicit concerted and appropriate responses. The pigment-bearing cells called melanophores have a significant contribution to make in this field. Melanophores, which contain the dark brown or black pigment melanin, constitute an important class of chromatophores. They are highly specialized in the bidirectional and coordinated translocation of pigment granules when given an appropriate stimulus. The pigment granules can be stimulated to undergo rapid dispersion throughout the melanophores, making the cell appear dark, or to aggregate at the center, making the cell appear light. The major signals involved in pigment transport within the melanophores are dependent on a special class of cell surface receptors called G-protein-coupled receptors (GPCRs). Many of these receptors of adrenaline, acetylcholine, histamine, serotonin, endothelin and melatonin have been found on melanophores. They are believed to have clinical relevance to skin-related ailments and therefore have become targets for high throughput screening projects. The selective screening of these receptors requires the recognition of particular ligands, agonists and antagonists and the characterization of their effects on pigment motility within the cells. The mechanism of skin pigmentation is incredibly intricate, but it would be a considerable step forward to unravel its underlying physiological mechanism. This would provide an experimental basis for new pharmacotherapies for dermatological anomalies.

show abstract

The variances in histamine control skin-testing response between Asian/Pacific islanders and other racial groups

Cited by 2 publications

References 0 publications

The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker

The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker

Vertebrate melanophores as potential model for drug discovery and development: A review

Contact Info

Product

Resources

About