The vanadium compounds: Chemistry, synthesis, insulinomimetic properties

Role of Vanadium in Cellular and Molecular Immunology: Association with Immune‐Related Inflammation and Pharmacotoxicology Mechanisms

“…It is an early first-row transition metal (Group 5 with Z = 23), with an electronic configuration of [Ar]3d 3 4s 2 , having two natural isotopes, 51 V and 50 V. Its presence in biological systems in the marine and terrestrial environment has been well-established over the years [ 4 ]. It is encountered, among others, in vanadium-dependent haloperoxidases and alternative nitrogenases [ 5 ]. Moreover, various vanadium species have been found to exhibit significant effects as external cofactors, inhibiting the function of a wide range of enzymes (glyceraldehyde-3-phosphate dehydrogenase, lipoprotein lipase, tyrosine phosphorylase, glucose-6-phosphate dehydrogenase, glycogen synthase, adenylate cyclase, and cytochrome oxidase) and stimulating the function of others (Na + -K + -ATPase, H + /K + -ATPase, myosin ATPase, dynein, adenylate kinase, phosphofructokinase, and choline esterase) [ 6 , 7 ].…”

Design, Synthesis and Pharmacological Evaluation of Novel Vanadium-Containing Complexes as Antidiabetic Agents

“…It is well known that both V(IV) and V(V) complexes show insulin mimetic effects [6] , however it is generally considered that the most effective insulin-mimetic vanadium complexes are neutral V(IV) compounds of the general formula VO[L 2 ] 0 . Several such VOL 2 type complexes with hypoglycemic activity have already been patented.…”

“…Vanadium compounds, in particular organic derivatives, are effective oral insulinomimetics, which inhibit lipolysis, decrease blood glucose levels (BGL) in animals and in clinical trials, and stimulate insulin secretion in experimental models of Diabetes Mellitus (DM) [1] – [5] . Although mechanisms of the insulin mimetic effect of vanadium complexes still have to be clarified, their ability to sensitize peripheral tissues to insulin and to reduce insulin resistance attracts significant attention in the context of their potential use for the treatment of Diabetes Type 1 (DM1), Diabetes Type 2 (DM2) and obesity [6] , [7] .…”

Design, synthesis andin vitrobactericidal/fungicidal screening of some vanadyl(IV)complexes with mono- and di-substituted ONS donor triazoles

“…The most important aspect is; its ability to enhance the activity of insulin mimetic 13,14 in diabetes mellitus of human pathophysiological condition. Vanadyl(IV) complexes with bi-dentate ligands bound to the vanadium metal through oxygen and nitrogen atoms, have been broadly focused in recent years due to their significant efficiency as insulin mimetic compounds 15,16 . Orally active medication of these compounds as drug represents an important advancement in the curative approach of human diabetes mellitus.…”