The values of (1,3)-β-D-glucan and galactomannan in cases of invasive fungal rhinosinusitis

Wei, Hongzheng; Li, Yunchuan; Han, Demin; Wang, Xiangdong; Liu, Xin; He, Shuai; Lü, Xinxin

doi:10.1016/j.amjoto.2020.102871

Cited by 6 publications

(19 citation statements)

References 15 publications

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“…Tissue culture and sensitivities provide important information on planning treatment of AIFS based on organism. Tissue fungal culture from operatively collected tissue has been shown to have the highest yield 7,17,28,31,33,57,60–65 . In addition, direct microscopy of the tissue specimens also allows for detection of fungal elements, but it may not allow for precise identification of organism and susceptibilities.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies combined ophthalmoplegia, diplopia, vision changes, and other ocular symptoms into a category such as “visual dysfunction.” 25,55 Similarly, the descriptions of pain (facial, orbital, headache, etc.) are generally heterogeneous 26,31 . A minority of articles did not provide information on symptom prevalence.…”

Section: Signs and Symptomsmentioning

confidence: 99%

“…Cranial nerve symptoms (25% to 49%), 30,33,39,57 including facial anesthesia (8% to 55%), 5,7,15,31,37–38,56,58 palatal anesthesia (up to 8%), 15 and facial paralysis (25% to 44%), 33,47 as well as ophthalmologic symptoms/symptoms, which include loss of visual acuity (26% to 87%), 17,26,30,38 proptosis (16% to 100%), 35,45,47 ophthalmoplegia (17% to 60%), 28,38,42,58 diplopia/extraocular muscle weakness (9% to 50%), 7,24,46,55 and ptosis (up to 100% in some series) 26,35,45 frequently develop if the disease extends outside the sinonasal cavity.…”

Section: Signs and Symptomsmentioning

confidence: 99%

“…Tissue fungal culture is an important component of AIFS diagnosis and treatment 7,17,28,31,33,60,61 . Intraoperatively collected tissue or aspirates, not swabs, maximize yield 62 .…”

Section: Laboratory and Microbiology Diagnosticsmentioning

confidence: 99%

“…Serum analysis for the fungal cell wall constituent (1,3)‐β‐D‐glucan (BDG) has been used to detect IFIs, although data are conflicting on diagnostic accuracy 75 . Several antibiotics, bacteremia, and malignancy can cause false‐positive results and BDG is not specific to a fungal species 31,75,76 . Heterogeneous cutoffs (>151.5, >59, and >30 pg/mL) have been used to examine diagnostic accuracy and prognosis in a limited number of patients, often too small to calculate meaningful statistics 27,31,43 .…”

Section: Laboratory and Microbiology Diagnosticsmentioning

confidence: 99%

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Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence‐Based Review with Recommendations

Roland

Humphreys

et al. 2023

Int Forum Allergy Rhinol

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BackgroundAcute invasive fungal sinusitis (AIFS) is an aggressive disease that requires prompt diagnosis and multidisciplinary treatment given its rapid progression. However, there is currently no consensus on diagnosis, prognosis, and management strategies for AIFS, with multiple modalities routinely employed. The purpose of this multi‐institutional and multidisciplinary evidence‐based review with recommendations (EBRR) is to thoroughly review the literature on AIFS, summarize the existing evidence, and provide recommendations on the management of AIFS.MethodsThe PubMed, EMBASE, and Cochrane databases were systematically reviewed from inception through January 2022. Studies evaluating management for orbital, non‐sinonasal head and neck, and intracranial manifestations of AIFS were included. An iterative review process was utilized in accordance with EBRR guidelines. Levels of evidence and recommendations on management principles for AIFS were generated.ResultsA review and evaluation of published literature was performed on 12 topics surrounding AIFS (signs and symptoms, laboratory and microbiology diagnostics, endoscopy, imaging, pathology, surgery, medical therapy, management of extrasinus extension, reversing immunosuppression, and outcomes and survival). The aggregate quality of evidence was varied across reviewed domains.ConclusionBased on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidisciplinary team via a combination of surgery (including resection whenever possible), antifungal therapy, and correcting sources of immunosuppression. Higher quality (i.e., prospective) studies are needed to better define the roles of each modality and determine diagnosis and treatment algorithms.

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Section: Discussionmentioning

confidence: 99%

Section: Signs and Symptomsmentioning

confidence: 99%

Section: Signs and Symptomsmentioning

confidence: 99%

“…Tissue fungal culture is an important component of AIFS diagnosis and treatment 7,17,28,31,33,60,61 . Intraoperatively collected tissue or aspirates, not swabs, maximize yield 62 .…”

Section: Laboratory and Microbiology Diagnosticsmentioning

confidence: 99%