The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict preeclampsia

Uyar, İbrahim; Kurt, Sefa; Demirtaş, Ömer; Gürbüz, Tutku; Aldemir, Onur Süleyman; Keser, Buket; Taşyurt, Abdullah

doi:10.1007/s00404-014-3563-3

Cited by 16 publications

(11 citation statements)

References 22 publications

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“…The first trimester UAD has elusive or limited diagnostic accuracy in predicting preeclampsia and FGR [3,11,12,[57][58][59][60][61][62][63][64][65][66][67][68][69][70] IV 9…”

Section: Methodsmentioning

confidence: 99%

“…(1) the first trimester UAD indices are highly predictive of both preeclampsia and FGR [5,7,9,10,; (2) the first trimester UAD is highly predictive of preeclampsia and fairly predictive or not predictive of the FGR [1,2,8,; (3) the first trimester UAD has elusive or limited diagnostic accuracy in preeclampsia and FGR [3,11,12,[57][58][59][60][61][62][63][64][65][66][67][68][69][70]; and (4) the first trimester UAD indices are not predictive of preeclampsia or FGR [6,[71][72][73][74][75][76][77][78].…”

Section: Problem Definitionmentioning

confidence: 99%

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Predictive accuracy of the first trimester Doppler scan: a meta-study

Matevosyan

2015

Wien Med Wochenschr

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“…The first trimester UAD has elusive or limited diagnostic accuracy in predicting preeclampsia and FGR [3,11,12,[57][58][59][60][61][62][63][64][65][66][67][68][69][70] IV 9…”

Section: Methodsmentioning

confidence: 99%

Section: Problem Definitionmentioning

confidence: 99%

Predictive accuracy of the first trimester Doppler scan: a meta-study

Matevosyan

2015

Wien Med Wochenschr

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“…Otra investigación en pacientes con quemaduras severas demostró que el aumento en las concentraciones de PNC y la disminución de la proteinuria, reflejo de la disminución del daño capilar, están asociadas con un menor número de complicaciones (26) . Al igual que esta investigación, un estudio previo no fue capaz de obtener datos sobre la correlación entre los péptidos natriuréticos y los valores de plaquetas, fosfatasa alcalina y proteinuria (27) .…”

Section: Resultsunclassified

Péptido natriurético cerebral sérico en preeclámpticas y embarazadas normotensas

Mejia-Montilla

Reyna-Villasmil

Bolívar

et al. 2017

Rev peru ginecol obstet.

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Objetivo: Comparar las concentraciones séricas de péptido natriurético cerebral en pacientes con preeclampsia y embarazadas normotensas sanas. Diseño: Estudio de casos y controles. Institución: Hospital Central “Dr. Urquinaona”, Maracaibo, Venezuela. Participantes: Se seleccionó un total de 180 embarazadas. Se incluyeron 90 preeclámpticas como grupo de estudio (grupo A) y un grupo de control seleccionado por tener edad e índice de masa corporal similares al grupo de estudio, que consistió en 90 embarazadas normotensas sanas (grupo B). Métodos: Las muestras de sangre se recolectaron en todas las pacientes antes del parto e inmediatamente después del diagnóstico en el grupo A, para determinar las concentraciones de péptido natriurético cerebral. Principales medidas de resultados: Características generales, concentraciones de péptido natriurético cerebral y eficacia diagnóstica. Resultados: Se encontraron diferencias estadísticamente significativas en las concentraciones séricas de péptido natriurético cerebral entre las pacientes del grupo A (65,1 +/- 14,1 pg/mL) y las pacientes del grupo B (43,2 +/- 9,8 pg/mL; p < 0,001). No se observaron correlaciones significativas con los valores de presión arterial sistólica y diastólica en las preeclámpticas (p = ns). Un valor de corte de 55 pg/mL presentó un valor por debajo de la curva de 0,88, sensibilidad 71,1%, especificidad 83,3%, valor predictivo positivo 81,0% y valor predictivo negativo 74,2%, con una exactitud diagnóstica del 77,2%. Conclusión: Las preeclámpticas presentaron concentraciones séricas significativamente más altas de péptido natriurético cerebral al compararlo con embarazadas normotensas sanas.

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“…Studies have reported elevated levels of NT-pro BNP in established pre-eclampsia with or without ventricular failure [ 14 , 16 , 37 ], but the benefit of using NT-pro BNP for predicting pre-eclampsia is uncertain [ 38 , 39 ]. A recent study reported a better predictive value for pre-eclampsia when adding NT-pro BNP to the existing biomarkers (soluble FMS-like tyrosine kinase 1 and placental growth factor) [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy-specific Reference Intervals for BNP and NT-pro BNP—Changes in Natriuretic Peptides Related to Pregnancy

Dockree

Brook

Shine

et al. 2021

Journal of the Endocrine Society

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Background Cardiac disease is the leading cause of maternal mortality in the UK, so accurate cardiovascular diagnoses in pregnancy are essential. BNP (B-type natriuretic peptide) and NT-pro BNP (N-terminal-pro BNP) are useful clinical tools for investigating suspected peripartum cardiomyopathy but, as the pregnancy-specific reference intervals are undefined, it is uncertain how they should be interpreted in pregnant women. Methods Longitudinal study of 260 healthy pregnant women, with sampling in each trimester to define 95% reference intervals. Results The upper reference limit for NT-pro BNP was 200 pg/mL in the first and second trimesters, and 150 pg/mL in the third. Levels were significantly reduced in overweight women in the third trimester (p=0.0001), which supports the partitioning of reference intervals by BMI. The upper limit for BNP was 50 pg/mL, with no detectable trimester-related differences. Whilst other biomarkers (haemoglobin and platelets) fell throughout pregnancy, both natriuretic peptides were initially elevated before falling by the third trimester, suggesting that the observed changes in natriuretic peptides are driven by dynamic interplay between cardiac strain and progressive haemodilution. NT-pro BNP in the first trimester was inversely associated with neonatal birthweight at term (p=0.011). Conclusions Cardiac biomarkers have an important role for investigating suspected disease in high-risk pregnant women, but a robust assessment of the levels expected in healthy pregnant women is an essential prerequisite to their application in clinical practice. This study has defined trimester- and BMI-specific reference intervals for NT-pro BNP and BNP, which may improve how women with suspected cardiovascular disease are investigated in pregnancy.

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The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict preeclampsia

Cited by 16 publications

References 22 publications

Predictive accuracy of the first trimester Doppler scan: a meta-study

Predictive accuracy of the first trimester Doppler scan: a meta-study

Péptido natriurético cerebral sérico en preeclámpticas y embarazadas normotensas

Pregnancy-specific Reference Intervals for BNP and NT-pro BNP—Changes in Natriuretic Peptides Related to Pregnancy

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