The Value of the Apparent Diffusion Coefficient in Differentiating Stage IA Endometrial Carcinoma From Normal Endometrium and Benign Diseases of the Endometrium

Wang, Junping; Yu, Tao; Renju, Bai; Sun, Hongzan; Zhao, Xin; Li, Yajun

doi:10.1097/rct.0b013e3181d0f666

Cited by 38 publications

(23 citation statements)

References 15 publications

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“…The accuracy of detecting myometrial invasion by endometrial cancer using T2-weighted images varies between 77% and 87% (3)(4)(5), whereas that using DCE is about 89%-91% (4,(6)(7)(8)(9). Recent reports suggest that the diagnostic accuracy of a combination of diffusionweighted imaging (DWI), T2WI, and DCE is more than that of imaging without DWI (10)(11)(12). However, preoperative MRI is still not a perfect imaging tool for analyzing cancers.…”

Section: Discussionmentioning

confidence: 95%

Diagnostic possibility of diffusion tensor imaging for the evaluation of myometrial invasion in endometrial cancer: An ex vivo study

Toba¹,

Matsuda²,

Sakurai³

et al. 2011

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 95%

Diagnostic possibility of diffusion tensor imaging for the evaluation of myometrial invasion in endometrial cancer: An ex vivo study

Toba¹,

Matsuda²,

Sakurai³

et al. 2011

Magnetic Resonance Imaging

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“…9). 12,18 On dynamic contrast-enhanced (DCE)-MRI, endometrial hyperplasia shows progressive enhancement, enhancing similar to or greater than adjacent myometrium. [12][13][14] Sometimes, small lowsignal-intensity cystic foci (cystic glandular dilatations) can be seen on delayed contrast-enhanced images.…”

Section: Benignmentioning

confidence: 99%

“…11,14 Polyps demonstrate less restricted diffusion than malignant lesions; Fujii et al 15 reported a mean apparent diffusion coefficient value of 1.44 Ϯ 0.34 for benign lesions and 0.98 Ϯ 0.19 for malignant lesions with an accuracy of 92%. [15][16][17][18] Endometrial polyps are typically removed to alleviate symptoms and to evaluate for atypical hyperplasia or carcinoma or both. [10][11][12] The risk of malignancy is related to polyp size and patient age.…”

Section: Benignmentioning

confidence: 99%

Magnetic Resonance Imaging of Benign and Malignant Uterine Neoplasms

Leursen

Gardner

Sagebiel

et al. 2015

Seminars in Ultrasound, CT and MRI

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“…DWI imaging of endometrial tumors has decreased ADC values (108)(109)(110)(111)(112)(113)(114)(115)(116). Endometrial carcinoma is clearly depicted as an area of increased signal intensity relative to the surrounding hypointense myometrium on DWI (116).…”

Section: Female Pelvis Applicationsmentioning

confidence: 99%

“…Endometrial carcinoma is clearly depicted as an area of increased signal intensity relative to the surrounding hypointense myometrium on DWI (116). ADC measurements have the potential to quantitatively differentiate Stage IA endometrial carcinoma from normal endometrium, endometrial dysplasia and benign diseases of the endometrium, such as endometrial hyperplasia, adenomyosis, submucosal leiomyoma, and endometrial polyps (108)(109)(110)(111)(112)(113)(114)(115)(116). DWI and combined DWI/T2W MRI can increase the overall detection sensitivity for endometrial carcinoma (113).…”

Section: Female Pelvis Applicationsmentioning

confidence: 99%

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Türkbey

Aras

Karabulut

et al. 2011

Diagn Interv Radiol

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Imaging is used to detect, characterize, and monitor cancer. Recently, diffusion-weighted magnetic resonance imaging (DWI) has become a useful adjunct for assessing tumors with magnetic resonance imaging (MRI). DWI involves the acquisition of a magnetic resonance signal related to random thermal motion (Brownian motion) or the "diffusion" of water protons in tissue. The signal obtained with DWI is a measure of the net displacement of water molecules, e.g., the water path length in the extracellular, intracellular and intravascular spaces. This motion is largely random and can be reduced by structural barriers, such as cell membranes and collagen. Restricted diffusion in biological tissues is inversely proportional to tissue cellularity and the integrity of cell membranes, and it can be quantified with apparent diffusion coefficient (ADC) measurements (1). Depending on the microarchitecture, either restricted or increased diffusion can occur in malignant tumors. For instance, diffusion is restricted in cellular portions of the tumor, but it may be increased in necrotic portions (2, 3). Other causes of enhanced diffusion include increased water content arising from intratumoral edema and cystic tumor components (4-6).Although initially used to evaluate neurological diseases, the applications of DWI have been extended to oncologic imaging throughout the body made possible by improvements in MRI hardware and new sequences. The use of DWI as a complement to conventional MRI methods has led to improvements in the detection and characterization of tumors, treatment response monitoring, and detection of recurrence in oncology patients. Basic concepts of DWIIn 1965, Stejskal and Tanner (7) proposed the application of a symmetric pair of additional gradients on either side of the 180˚ refocusing radiofrequency pulse. The Stejskal-Tanner sequence is still the basis of modern DWI. For static water molecules, the phasing effect caused by the first gradient will be reversed by the second gradient, leading to no signal loss; however, this phasing effect will not be completely reversed if the water molecules are not stationary, which results in the observed well-known diffusion signal decay. The amount of diffusion weighting is determined by the b value, which describes the amplitude, duration of the applied gradient, and time interval between the two diffusion gradients (4). The degree of signal attenuation from water molecules is cor- ABSTRACT Diffusion-weighted magnetic resonance imaging (MRI), which involves the acquisition of a magnetic resonance signal related to the Brownian motion of water protons in tissue, has become a useful technique for assessing tumors. In this article, we review the basic concepts, imaging strategies, and body applications of diffusion-weighted MRI in detecting and monitoring cancer.

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The Value of the Apparent Diffusion Coefficient in Differentiating Stage IA Endometrial Carcinoma From Normal Endometrium and Benign Diseases of the Endometrium

Cited by 38 publications

References 15 publications

Diagnostic possibility of diffusion tensor imaging for the evaluation of myometrial invasion in endometrial cancer: An ex vivo study

Diagnostic possibility of diffusion tensor imaging for the evaluation of myometrial invasion in endometrial cancer: An ex vivo study

Magnetic Resonance Imaging of Benign and Malignant Uterine Neoplasms

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

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