Diagnostic possibility of diffusion tensor imaging for the evaluation of myometrial invasion in endometrial cancer: An ex vivo study

Toba, Mikayo; Matsuda, Naoyuki; Sakurai, Urara; Yamada, Ichiro; Eishi, Yoshinobu; Kubota, Toshiro

doi:10.1002/jmri.22693

Cited by 24 publications

(20 citation statements)

References 28 publications

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“…Current published studies include ex vivo and in vivo studies. [11][12][13][14][15][16] In 2006, threedimensional fibre architecture of the normal human uterus based on DTI has been ex vivo evaluated in five samples by Weiss et al 11 Toba et al 12 ex vivo study showed that DTI might be a useful tool for the diagnosis of myometrial invasion of uterine endometrial cancer. However, fractional anisotropy (FA) value of a normal uterus has not been thoroughly investigated yet.…”

Section: Yonglan He and Ning Ding Have Contributed Equally To This Armentioning

confidence: 99%

3-T diffusion tensor imaging (DTI) of normal uterus in young and middle-aged females during the menstrual cycle: evaluation of the cyclic changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values

Ding²,

Li³

et al. 2015

BJR

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Section: Yonglan He and Ning Ding Have Contributed Equally To This Armentioning

confidence: 99%

3-T diffusion tensor imaging (DTI) of normal uterus in young and middle-aged females during the menstrual cycle: evaluation of the cyclic changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values

Ding²,

Li³

et al. 2015

BJR

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“…The study was carried out on a 3T MRI, and DTI was obtained with a b value of (0.600 smm -2 ) (10). In an ex vivo study published by Toba et al (8), data were obtained from five ex vivo organs of patients subjected to hysterectomy for medical reasons. In this study, a 4. were statistically higher than the tumor (0.216±0.05) (p<0.01…”

Section: Discussionmentioning

confidence: 99%

“…Diffusion is not a one-dimensional process, and in the organized viscera, diffusion does not occur equally in all directions. The directionality of water diffusion is defined by anisotropy index (fractional anisotropy), which determines microstructural arrangement, like the quantity and direction of fibrous tissue (8,9). In tissues like the kidneys, due to the presence of collecting ducts and tubules, or the uterus, due to the muscle structures, diffusion has anisotropic properties.…”

mentioning

confidence: 99%

“…Diffusion tensor imaging is the best method to evaluate the anisotropic properties of solid organs, and it, unlike DWI, permits the analysis of diffusion along multiple directions. Recently, the improvement of this technique made it a useful and complementary sequence to conventional imaging techniques for demonstrating the fiber structures of the uterus (4,8,(10)(11)(12)(13).…”

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confidence: 99%

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Diffusion Tensor Imaging of the Uterine Zones Related to the Menstrual Cycle and Menopausal Status at 3 Tesla MRI

Kılıçkesmez¹,

Fırat

Oygen

et al. 2016

Balkan Med J

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Background: Diffusion and diffusion tensor imaging techniques (DTI) are widely available and used both in central nervous system and body imaging, including gynecological diseases. Aims: The aims of this study were to assess the capability of DTI of uterine zones in relation to the menstrual cycle and ascertain the normal apparent diffusion coefficient and fractional anisotropy values at 3T magnetic resonance imaging (MRI).

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“…The addition of DWI, and DTI sequences which serve as functional imaging in the MRI protocol for the evaluation of uterine pathologies have been offered by several papers [2,3,7,8] . Besides quantitative evaluation with values has been found out to be effective in the discrimination of malignancy from benign lesions [1720] .…”

Section: Dwi and Dti Of Diseased Uterusmentioning

confidence: 99%

Diffusion-weighted and diffusion-tensor imaging of normal and diseased uterus

Bozkurt

Nazli

et al. 2015

WJR

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Owing to technical advances and improvement of the software, diffusion weighted imaging and diffusion tensor imaging (DWI and DTI) greatly improved the diagnostic value of magnetic resonance imaging (MRI) of the pelvic region. These imaging sequences can exhibit important tissue contrast on the basis of random diffusion (Brownian motion) of water molecules in tissues. Quantitative measurements can be done with DWI and DTI by apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values respectively. ADC and FA values may be changed by various physiological and pathological conditions providing additional information to conventional MRI. The quantitative DWI assists significantly in the differentiation of benign and malignant lesions. It can demonstrate the microstructural architecture and celluler density of the normal and diseased uterine zones. On the other hand, DWI and DTI are useful for monitoring the treatment outcome of the uterine lesions. In this review, we discussed advantages of DWI and DTI of the normal and diseased uterus. Core tip: Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) sequences greatly improved the diagnostic value of magnetic resonance imaging of the uterus with the additional benefits of functional information. They reflect the microstructural architecture and cellular density of the uterine zones and enable quantitative evaluation. Depending on this review, DWI and DTI appear to be applicable and reliable methods for demonstrating physiological changes of the uterus, benign and malignant characteristics of uterine zones

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Diagnostic possibility of diffusion tensor imaging for the evaluation of myometrial invasion in endometrial cancer: An ex vivo study

Abstract: Our ex vivo study suggests that DTI might be a useful tool for the diagnosis of myometrial invasion of uterine endometrial cancer ex vivo.

Cited by 24 publications

References 28 publications

3-T diffusion tensor imaging (DTI) of normal uterus in young and middle-aged females during the menstrual cycle: evaluation of the cyclic changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values

3-T diffusion tensor imaging (DTI) of normal uterus in young and middle-aged females during the menstrual cycle: evaluation of the cyclic changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values

Diffusion Tensor Imaging of the Uterine Zones Related to the Menstrual Cycle and Menopausal Status at 3 Tesla MRI

Diffusion-weighted and diffusion-tensor imaging of normal and diseased uterus

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