The Value of Preoperative Plasma VEGF Levels in Urothelial Carcinoma of the Bladder Treated with Radical Cystectomy

Mori, Keiichiro; Schuettfort, Victor M.; Katayama, Satoshi; Laukhtina, Ekaterina; Pradère, Benjamin; Quhal, Fahad; Motlagh, Reza Sari; Mostafaei, Hadi; Grossmann, Nico C.; Rajwa, Paweł; König, Frederik; Aydh, Abdulmajeed; Soria, Francesco; Moschini, Marco; Karakiewicz, Pierre I.; Lotan, Yair; Scherr, Douglas; Nyírády, Péter; Teoh, Jeremy Yuen‐Chun; Egawa, Shin; Compérat, Éva; Shariat, Shahrokh F.

doi:10.1016/j.euf.2021.08.006

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Among the many studied angiogenic factors, VEGF plays a significant and principal role in BC angiogenesis. Elevated levels of VEGF expression are generally associated with worse outcomes for patients with BC [ 4 , 27 – 31 , 32 •]. Notably, the level of VEGF expression did not predict outcomes for patients with BC in many studies [ 33 – 37 ].…”

Section: Clinical Assessment Of Angiogenesis In Bladder Cancersmentioning

confidence: 99%

An Overview of Angiogenesis in Bladder Cancer

2023

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Purpose of the Review Angiogenesis plays a key role in bladder cancer (BC) pathogenesis. In the last two decades, an increasing number of publications depicting a multitude of novel angiogenic molecules and pathways have emerged. The growing complexity necessitates an evaluation of the breadth of current knowledge to highlight key findings and guide future research. Recent Findings Angiogenesis is a dynamic biologic process that is inherently difficult to assess. Clinical assessment of angiogenesis in BCs is advancing with the integration of image analysis systems and dynamic contrast-enhanced and magnetic resonance imaging (DCE-MRI). Tumour-associated macrophages (TAMs) significantly influence the angiogenic process, and further research is needed to assess their potential as therapeutic targets. A rapidly growing list of non-coding RNAs affect angiogenesis in BCs, partly through modulation of vascular endothelial growth factor (VEGF) activity. Vascular mimicry (VM) has been repeatedly associated with increased tumour aggressiveness in BCs. Standardised assays are needed for appropriate identification and quantification of VM channels. Summary This article demonstrates the dynamic and complex nature of the angiogenic process and asserts the need for further studies to deepen our understanding.

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Section: Clinical Assessment Of Angiogenesis In Bladder Cancersmentioning

confidence: 99%

An Overview of Angiogenesis in Bladder Cancer

2023

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“…1 Thus, identifying preoperative biomarkers capable of capturing the biological and clinical potential of each tumor variety is crucial for further refinement of risk stratification in patients with UCB. 2,3 Vascular cell adhesion molecule-1 (VCAM-1) involved in cellular adhesion is closely associated with inflammation, immunological disorders, tumor angiogenesis, and metastasis. 4 Although VCAM-1 is reportedly associated with oncological outcomes in several tumor varieties, 4 the predictive and/or prognostic value of blood VCAM-1 remains relatively unexplored in patients with UCB undergoing radical cystectomy (RC).…”

Section: Pastmentioning

confidence: 99%

ASO Author Reflections: Is Vascular Cell Adhesion Molecule-1 (VCAM-1) a Promising Biomarker in Urothelial Carcinoma of the Bladder?

et al. 2022

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Impact of sex on outcomes after surgery for non-muscle-invasive and muscle-invasive bladder urothelial carcinoma: a systematic review and meta-analysis

Mori

Yanagisawa²,

Katayama³

et al. 2022

World J Urol

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Purpose To assess the prognostic value of sex for non-muscle-invasive/muscle-invasive bladder urothelial carcinoma (NMIBC/MIBC) treated with radical surgery. Methods The PubMed, Web of Science, and Scopus databases were searched in November 2021 according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. Studies were deemed eligible if they involved the comparison of the overall, cancer-specific, progression, and recurrence-free survival of patients with NMIBC/MIBC. Formal sex-stratified meta-analyses of these outcomes were performed. Results Thirty-one studies, which included 32,525 patients with NMIBC, and 63 studies, which included 85,132 patients with MIBC, were eligible for review and meta-analysis. Female sex was associated with worse cancer-specific survival (pooled hazard ratio [HR], 1.21; 95% confidence interval [CI], 1.11–1.31) and overall survival (pooled HR, 1.02; 95% CI, 1.00–1.05) in patients with MIBC. In contrast, however, sex was not associated with cancer-specific survival (pooled HR, 1.01; 95% CI, 0.70–1.46), progression-free survival (pooled HR, 1.04; 95% CI, 0.88–1.24), and recurrence-free survival (pooled HR, 1.06; 95% CI, 0.98–1.16) in patients with NMIBC. Conclusions Sex is associated with an increased risk of worse survival outcomes in patients with MIBC but not in those with NMIBC. Given the genetic and social differences between sexes, sex may represent a key factor in the clinical decision-making process.

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The Value of Preoperative Plasma VEGF Levels in Urothelial Carcinoma of the Bladder Treated with Radical Cystectomy

Cited by 3 publications

References 30 publications

An Overview of Angiogenesis in Bladder Cancer

An Overview of Angiogenesis in Bladder Cancer

ASO Author Reflections: Is Vascular Cell Adhesion Molecule-1 (VCAM-1) a Promising Biomarker in Urothelial Carcinoma of the Bladder?

Impact of sex on outcomes after surgery for non-muscle-invasive and muscle-invasive bladder urothelial carcinoma: a systematic review and meta-analysis

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