The Value of Platelet Indices in Henoch- Schonlein Purpura

Abstract

Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood and is usually associated with thrombocytosis. Platelet indices, mean platelet volume (MPV) and platelet distribution width (PDW) have recently been described as markers of platelet activation and function. The aim of this retrospective study is to investigate the value of platelet indices in HSP. Methods: The study was conducted in 117 HSP patients diagnosed with HSP and 68 age-and sexmatched healthy controls with a retrospective design. The data for both patient and control groups were extracted from the hospital' s computerized database following approval by the local ethics commitee. Results: The mean leukocyte and platelet counts were significantly higher in HSP patients than in the control group (p<0.01), while mean MPV and PDW values did not differ in the two groups. Furthermore, the platelet indices did not differ between patients with and without multisystemic involvement. Conclusions: The results of our study suggest that platelet indices cannot be used as a laboratory markers either in diagnosis of HSP or predicting severe multisystemic disease in HSP.

Role of Hematological Parameters in the Diagnosis of Juvenile Idiopathic Arthritis in Children with Arthritis

“…Algunos estudios han reportado que el VPM fue menor en la fiebre reumática aguda, la brucelosis y la HSP que en los voluntarios sanos 20,21 . Sin embargo, en otro estudio que incluyó a niños con HSP, no hubo diferencias en los índices plaquetarios entre los grupos de casos y de control 22 . Los hallazgos de este estudio revelaron que el recuento medio de plaquetas y el VPM fueron similares en los pacientes con y sin artritis por AIJ.…”