Ig-A vasküliti (Henoch-Schönlein purpurası) Tanısı Alan Çocuklarda Trombosit İndekslerinin Klinik Önemi

Türe, Esra; Yazar, Abdullah; Akın, Fatih

doi:10.16899/gopctd.387725

Cited by 1 publication

(4 citation statements)

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“…IgAV/HSP is most common between 3-15 years of age and peaks between 5-7 years of age [9][10][11]. In studies from Turkey, the mean age of IgAV/HSP has been reported to be between 7 and 9 years [3,6,[12][13][14]. In our study, the age of onset was 7.5±3.0 years, and males and females were equally affected.…”

Section: Discussionsupporting

confidence: 55%

“…In our study, the age of onset was 7.5±3.0 years, and males and females were equally affected. In the literature, besides the studies reporting gender equality, there are also studies showing male, or female dominance [3,6,[12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…There was no case of massive rectal bleeding. The rate of GI involvement in IgAV/HSP cases has been reported to be between 32-72% [3,6,[12][13][14]19]. Intussusception is the most important surgical complication in IgAV/HSP and develops in 0.7-13.6% [20].…”

Section: Discussionmentioning

confidence: 99%

“…IgAV/HSP is seen especially in autumn, spring, and winter. This is explained by the relationship between IgAV/HSP and infections [3]. An upper respiratory tract infection occurs in about half of IgAV/HSP cases, but the disease is also associated with possible triggers such as vaccines and insect bites [4].…”

Section: Introductionmentioning

confidence: 99%

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Demographics, clinical, laboratory findings and treatment results of pediatric patients with IgA Vasculitis: Single-center experience

et al. 2022

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Objective: Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura (HSP), is a vasculitis characterized by the accumulation of IgA in the vessel walls. In this study, we purposed to evaluate the demographics, clinical and laboratory findings, and treatment and treatment responses of patients diagnosed with IgAV/HSP in our center. Methods: The records of 201 IgAV/HSP patients who were followed up in the pediatric nephrology-rheumatology clinic were evaluated retrospectively. Results: It was seen with the equal frequency between girls and boys. While all patients had purpura, other findings were gastrointestinal, joint, renal, subcutaneous edema, and testicular involvement, in order of frequency. The rate of patients who developed intussusception was 2.5%, and none required surgical treatment. Biopsy was performed in patients with persistent proteinuria or hematuria. Histopathological diagnoses were mesangial proliferation, crescent, and minimal change, respectively. While the rate of renal involvement was high in cases with rash and relapse (p=0.046), there was no difference in gastrointestinal and joint involvement. In the histopathological findings of the boys, the crescent was higher than in the girls (p=0.017). Conclusion: IgAV/HSP generally has a good prognosis, but some patients suffer from renal involvement. In our study, renal histopathology in cases with renal involvement showed milder findings in girls than in boys, but there was no difference in other findings. Renal involvement was higher in relapsed patients.

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