The Value of Plasma Oxytocinase in the Assessment of Fetal‐Placental Function

Abstract

Preliminary results in the study of plasma I-cystine aminopeptidase levels as a test of fetaI-placental function are reported. A significant correlation has been obtained between plasma 1-cystine aminopeptidase and the total 24-hour urinary oestrogen excretion. It is concluded that serial determinations of plasma I-cystine aminopeptidase levels are of value in assessing fetal-placental function. , ,, 69: 409. 88: 977.

Physiology and Genetics of Reproduction

“…Among the placental enzymes indicated in Table II, the estimation of heat-stable alkaline phosphatase has been repeatedly suggested as a useful placental function test (for review, see Curzen and Varma, 1971; Curzen and Hensel, 1972;Dumont et aZ., 1969Dumont et aZ., ,1971Watney etaZ., 1970;Diaz Infante et aZ., 1971;Iyengar and Srikantia, 1970). Furthermore, diamine oxidase (histaminase) (Ahlmark, 1944;Swanberg, 1950) and L-cystine aminopeptidase (oxytocinase) (e.g., Babuna and Yenen, 1966;Blunt, 1971;Diaz Infante et al, 1971;Hensleigh and Krantz, 1970) and renin (e.g., Brown et aI., 1963) are also produced by the placenta and secreted into the maternal circulation. The plasma levels of some of these enzymes have also been advocated to be of value in the assessment of placental function.…”

Comparative prognostic value of serum placental and tissue oxytocinase, alkaline phosphatase and its heat-stable fraction in pregnancy at neuroendocrinological risk

“…Only a few authors emphasize that under pathologic conditions, mainly in gestoses and essential hypertension, a sudden rise or fall in HSAP concentration may be prognostically unfavorable [2, 13,26], and is an indication for strict monitoring rather than for therapeutic decisions [3]. CAPis considered by most authors to be useful in the diagnosis of threatened pregnancy [l, 4,5,7,8,16,18,20,21,22,28], although a few investigators hold the opposite opinion [9]. A special application of this enzyme assay is in the diagnosis of the hypothalamic post-pregnancy syndrome in pregnant women [23], and the combination of CAP with AP and cytohormonal vaginal smears may be of value in the diagnosis of primary and secondary placental insufficiency [30].…”

Diagnosis of Intrauterine Fetal Growth Retardation by Serial Serum Oxytocinase, Urinary Oestrogen and Serum Heat Stable Alkaline Phosphatase (Hsap) Estimations in Uncomplicated and Hypertensive Pregnancies

“…Babuna and Yenen (1966), Josephides and Turkington ( I 967) and Hensleigh and Krantz (l970), have indicated that serial serum oxytochase measurements can be a useful aid in monitoring placental function especially in pregnancies complicated by hypertension and pre-eclampsia. Tovey (1969) and Blunt (1971) found a significant correlation between maternal urinary oestrogen and serum oxytocinase activity in normal and complicated pregnancies, again suggesting that serum oxytocinase measurement was a useful guide to placental function. Kleiner (1969) and Hurry et al (1972) measuring leucine amino-peptidase and cystine amino-peptidase activity respectively, indicated that serial estimations of this group of enzymes was helpful in the diagnosis of intrauterine fetal growth retardation.…”