“…In patients suffering from diabetes or hypertension this percentage tends to behave in an oppo site way and they equal to 26.7%, 26.7%, 46.7% and 16%, 24%, 60%, respectively [9], This remains coherent with the statement that in pregnant women, threatened with mis carriages or premature deliveries, the enzyme values are still lower, though the ACTH-therapy in such cases enables the successful outcome of pregnancy. The substitutive ACTH-therapy, introduced in the 60s -led to the fact that instead of intrauterine fetal deaths observed in 80% of pregnancies in women with hypothalamic syndrome, now adays, the survival of such infants amounts to above 90% [12,13,15]. The clinical application of ACTH as the optional treaatment in hypothalamic insufficiency syn drome has appeared gradually very useful in preventing the premature labors or neonatal respiratory distress.…”