The value of IgG-uria in predicting renal failure in idiopathic glomerular diseases. A long-term follow-up study

Tofik, Rafid; Aziz, Rawa Abdul Redha; Reda, A.; Rippe, Bengt; Bakoush, Omran

doi:10.3109/00365513.2010.542828

Cited by 17 publications

(11 citation statements)

References 20 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a number of studies have been published investigating whether urinary excretion of these damage markers is associated with progression of CKD. For instance, the glomerular damage marker IgG and several markers of the proximal tubule were found to predict the onset of ESRD or renal function decline in CKD patients (14,15,28,29) and renal transplant recipients (27). Similar findings have been obtained for the urinary excretion of the distal tubular marker H-FABP (30) and the inflammation markers NGAL and MCP-1 (16,31).…”

Section: Discussionsupporting

confidence: 66%

Glomerular and Tubular Damage Markers in Individuals with Progressive Albuminuria

Nauta

Scheven

Meijer

et al. 2013

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

SummaryBackground and objectives Albuminuria is associated with risk for renal and cardiovascular disease. It is difficult to predict which persons will progress in albuminuria. This study investigated whether assessment of urinary markers associated with damage to different parts of the nephron may help identify individuals that will progress in albuminuria.Design, setting, participants, & measurements Individuals were selected from a prospective community-based cohort study with serial follow-up and defined as "progressors" if they belonged to the quintile of participants with the most rapid annual increase in albuminuria, and reached an albuminuria $150 mg/d during follow-up. Patients with known renal disease or macroalbuminuria at baseline were excluded. Each progressor was matched to two control participants, based on baseline albuminuria, age, and sex. Furthermore, damage markers were measured in a separate set of healthy individuals.Results After a median follow-up of 8.6 years, 183 of 8394 participants met the criteria for progressive albuminuria. Baseline clinical characteristics were comparable between progressors and matched controls (n=366). Both had higher baseline albuminuria than the overall population. Urinary excretion of the glomerular damage marker IgG was significantly higher in progressors, whereas urinary excretion of proximal tubular damage markers and inflammatory markers was lower in these individuals compared with controls. Healthy individuals (n=109) had the lowest values for all urinary damage markers measured.Conclusions These data suggest that albuminuria associated with markers of glomerular damage is more likely to progress, whereas albuminuria associated with markers of tubulointerstitial damage is more likely to remain stable.

show abstract

Section: Discussionsupporting

confidence: 66%

Glomerular and Tubular Damage Markers in Individuals with Progressive Albuminuria

Nauta

Scheven

Meijer

et al. 2013

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…Contrary to our expectation, urine MCP-1 was not an independent predictor of long-term outcome in this cohort of patients with idiopathic chronic glomerulonephritis, while IgG-uria was [10]. This seems to contradict previous reports on the prognostic value of urine MCP-1 in patients with systemic diseases [11], [21]–[24].…”

Section: Discussioncontrasting

confidence: 99%

Urinary Concentration of Monocyte Chemoattractant Protein-1 in Idiopathic Glomerulonephritis: A Long-Term Follow-Up Study

2014

Self Cite

View full text Add to dashboard Cite

BackgroundMonocyte chemoattractant protein-1 (MCP-1), which is up regulated in kidney diseases, is considered a marker of kidney inflammation. We examined the value of urine MCP-1 in predicting the outcome in idiopathic glomerulonephritis.MethodsBetween 1993 and 2004, 165 patients (68 females) diagnosed with idiopathic proteinuric glomerulopathy and with serum creatinine <150 µmol/L at diagnosis were selected for the study. Urine concentrations of MCP-1 were analyzed by ELISA in early morning spot urine samples collected on the day of the diagnostic kidney biopsy. The patients were followed until 2009. The progression rate to end-stage kidney disease was calculated using Kaplan–Meier survival analysis. End-stage kidney disease (ESKD) was defined as the start of kidney replacement therapy during the study follow-up time.ResultsPatients with proliferative glomerulonephritis had significantly higher urinary MCP-1 excretion levels than those with non-proliferative glomerulonephritis (p<0.001). The percentage of patients whose kidney function deteriorated significantly was 39.0% in the high MCP-1 excretion group and 29.9% in the low MCP-1 excretion group. However, after adjustment for confounding variables such as glomerular filtration rate (GFR) and proteinuria, there was no significant association between urine MCP-1 concentration and progression to ESKD, (HR = 1.75, 95% CI = 0.64–4.75, p = 0.27).ConclusionOur findings indicate that progression to end-stage kidney disease in patients with idiopathic glomerulopathies is not associated with urine MCP-1 concentrations at the time of diagnosis.

show abstract

“…A high predictive value of outcome of HMW protein excretion has been observed in other types of GN; IgG in glomerulonephritis [23, 24], idiopathic membranous nephropathy [25–27], crescentic [28] and noncrescentic IgA nephropathy [29, 30] with different cutoffs for each type of GN; IgM (MW: 900 kDa) in ANCA-associated renal vasculitis [31] and type 2 diabetic nephropathy [32]. …”

Section: Discussionmentioning

confidence: 99%

Urinary IgG andα2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome

Bazzi¹,

Rizza

Casellato

et al. 2013

BioMed Research International

View full text Add to dashboard Cite

Objective. To assess whether high-molecular-weight proteins excretion predicts outcome and therapy-responsiveness in patients with FSGS and nephrotic syndrome. Research Design and Methods. Thirty-eight patients measured at biopsy fractional excretion of IgG (FEIgG) and urinary α2-macroglobulin/creatinine ratio (α2m/C). Low and high risk groups were defined by cutoffs assessed by ROC analysis. In all patients first-line therapy was with steroids alone or in combination with cyclophosphamide. Results. α2m/C and FEIgG were correlated with segmental sclerosis (r = 0.546; r = 0.522). Twenty-three patients (61%) entered Remission and 9 (24%) progressed to ESRD. Comparing low and high risk groups, by univariate analysis remission was predicted by FEIgG (77% versus 25%, P = 0.016) and α2m/C (81% versus 17%, P = 0.007) and ESRD at best by FEIgG (0% versus 75%, P < 0.0001) and α2m/C (4% versus 67%, P < 0.0001). By multivariate analysis FEIgG was the only independent predictor of remission and α2m/C the most powerful predictor of ESRD. Low and high risk groups of FEIgG and α2m/C in combination had very high predictive value of sustained remission and ESRD in response to therapy. Conclusions. FEIgG and α2m/C are powerful predictors of outcome and responsiveness to steroids and cyclophosphamide; their predictive value, if validated in prospective studies, may be useful in clinical practice suggesting first-line alternative treatments in high risk patients.

show abstract

The value of IgG-uria in predicting renal failure in idiopathic glomerular diseases. A long-term follow-up study

Cited by 17 publications

References 20 publications

Glomerular and Tubular Damage Markers in Individuals with Progressive Albuminuria

Glomerular and Tubular Damage Markers in Individuals with Progressive Albuminuria

Urinary Concentration of Monocyte Chemoattractant Protein-1 in Idiopathic Glomerulonephritis: A Long-Term Follow-Up Study

Urinary IgG andα2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome

Contact Info

Product

Resources

About