The Value of Histologic Differentiation of Basal Cell Carcinomas

Abstract

physical examination and accurately interpreted x-ray plates. If there are signs of obstructive emphysema, the source of the obstruction must be determined by bronchoscopy. It is surprising that such very minute bits of foreign material as the tiny sliver of peanut removed at the second bronchoscopy are not coughed up. Though these bodies may be small, the bronchial tree is unable to take care of them, and they remain as sources of continued irritation and the causes of later bronchiectasis. The longer the foreign material is allowed to remain in the bronchial tree, the more rapidly progressive is the bronchiectatic process. Needless to say, the treatment of bronchiectasis is long and complicated and far from satisfactory. For this reason, prophylaxis is by far the more important factor. 9. R. L. (199747). Age, 2 5/12 years. Male. This patient was admitted on March 21, 1936, because of abdominal pain following the ingestion of a button 48 hours previously. The family history showed that the paternal grandmother had diabetes. The patient's past history was normal. He had been born with a right inguinal hernia, but, except for local swelling, it had never caused him any trouble. He had worn a truss from early infancy. Forty-eight hours before admission the child put a large button into his mouth, and suddenly coughed, choked and gagged as he swallowed it. Following this he vomited. Since that time he had complained of vague abdominal pain, but there had been no further vomiting. He had been able to eat without difficulty. On admission physical examination was normal, except for a slightly injected throat and a moderately large right inguinal hernia, which was supported by a truss. X-rays on admission showed a large button lying transversely in the esophagus at the level of the sternoclavicular joints.One-half hour after admission, under avertin anesthesia, esophagoscopy was performed. A 1 inch pearl button was removed without difficulty from FIG. 11. (Case 9) A-P film shows a button in the esophagus. the esophagus. Following operation the patient had no reaction whatever. He complained of no further pain in the abdomen and had no vomiting. He continued to eat well. Two days later, on March 23, 1936, he was discharged improved.Comment-It is surprising that a button of this size should remain so high in the esophagus for as long a period as 2 days without producing more difficulty in swallowing. Apparently the child was able to eat normally, and for this reason the mother had expected that the button had passed on down through the intestinal tract. The only symptoms were vague abdominal pains, and the failure to recover the button. The button, as is the case with esophageal foreign bodies, Mras found in a transverse position.THE since the recognition of the relatively Ju benign course of rodent or Jacobean ulcer and its differentiation as a basal cell carcinoma by Krompecher1 there has been much discussion among pathologists as to the proper classification of cutaneous carcinoma other than the epidermoid and adenocar...

Growth of periocular basal cell carcinomas

“…Scrutiny of earlier research on the growth of BCCs reveals that data were published up to 70 years ago and were based on small sample sizes; had ques-tionable study designs; and were retrospective studies with no description of the tumour site or histological type. [1][2][3][4] New Zealand has one of the highest incidences of skin cancers in the world. [5][6][7] Several factors contribute to this high incidence.…”

“…We defined nonaggressive BCCs as being of nodular or superficial type, and aggressive BCCs as being of infiltrative, micronodular, metatypical or mixed type. 3,4,[8][9][10][11][12][13][14] Aggressive BCCs accounted for 49Á0% (n = 57) of all types, of which micronodular was the most common type (30Á0%; n = 19). There was no association between aggressive BCCs and significant growth (P = 0Á84, Fisher's exact test).…”

“…Basal cell carcinomas (BCCs) have traditionally been considered as slow‐growing tumours. Scrutiny of earlier research on the growth of BCCs reveals that data were published up to 70 years ago and were based on small sample sizes; had questionable study designs; and were retrospective studies with no description of the tumour site or histological type …”

Differentiation in the Rodent Ulcer Group of Tumours

“…(b) They are abortive hair follicles (Haythorn, 1931;Warren, Gates and Butterfield, 1936). The term "abortive " here is a convenient one; it conceals the fact that the structures resemble no part of the follicle in any respect which will bear analysis.…”

“…His over-enthusiastic inclusion of the "transitional" squamous tumours of mucosae in his basal-cell carcinoma group was his only major error (Owen, 1930). Subsequent authors have been largely concerned either with alternative accounts of the histogenesis which have been on the whole less plausible (e.g., Borrman, 1904;Mallory, 1910;Kyrle, 1916;Haythorn, 1931;Foot, 1947), or with attempts at classification within the group (e.g., Darier and Ferrand, 1922;Montgomery, 1928Montgomery, , 1935Lacassagne, 1933;Warren, Gates and Butterfield, 1936;Foot, 1947).…”