Differentiation in the Rodent Ulcer Group of Tumours

Lennox, Bernard; Wells, Alan

doi:10.1038/bjc.1951.21

Cited by 34 publications

(6 citation statements)

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“…The existence and diagnosis of basosquamous carcinoma initially was debated in the 1950s and 1960s. Certain pathologists still do not believe that basosquamous carcinoma exists,3, 4 whereas others accept it as a “meta‐typical carcinoma.”5 Basosquamous carcinoma now has been widely accepted as a clinical entity with a significant occurrence rate among carcinomas of the skin. Basosquamous carcinoma also has been referred to as basaloid squamous carcinoma and basaloid squamous cell carcinoma.…”

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confidence: 99%

Basosquamous carcinoma

Martin

Edwards

Cawte

et al. 2000

Cancer

132

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BACKGROUND Basosquamous carcinoma is a rare malignancy, with features of both basal cell carcinoma and squamous cell carcinoma. Some authors believe that basosquamous carcinoma merely is a variant of basal cell carcinoma, whereas others have suggested that basosquamous carcinoma may behave more aggressively. To the authors' knowledge the largest published series to date, comprised of 35 cases, was reported > 20 years ago. The authors reviewed their recent experience with basosquamous carcinoma to identify prognostic factors influencing recurrence. METHODS The medical records of all patients with the diagnosis of basosquamous carcinoma treated at the University of Louisville‐affiliated hospitals between 1985–1988 were reviewed by a senior pathologist. Prognostic factors were analyzed using Cox regression analysis and the log rank test. RESULTS Thirty‐one cases of basosquamous carcinoma were identified in 28 patients. The median age at diagnosis was 68 years (range, 10–94 years). The median follow‐up was 60 months (range, 12–312 months). Seventy‐five percent of cases were located on the face, neck, and scalp. One patient had regional lymph node metastasis synchronous with the primary tumor. Patterns of recurrence were: local recurrence only (five patients), local recurrence plus regional lymph nodes (three patients), and pulmonary plus regional lymph nodes (one patient). One patient died of pulmonary metastasis. Significant factors predictive of recurrence (P < 0.01) were male gender, positive surgical resection margin, lymphatic invasion, and perineural invasion. Although tumor size was not a statistically significant factor overall (P = 0.076), the 3 patients with lymph node metastases had large tumors (measuring 2 cm, 5 cm, and 5 cm, respectively). CONCLUSIONS Basosquamous carcinoma is an aggressive epithelial neoplasm with a propensity for local recurrence and potential for distant metastatic spread. This behavior differs substantially from basal cell carcinoma. Complete resection with negative surgical margins is essential. Long term follow‐up for the detection of local recurrence and distant metastatic spread is recommended. Cancer 2000;88:1365–9. © 2000 American Cancer Society.

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confidence: 99%

Basosquamous carcinoma

Martin

Edwards

Cawte

et al. 2000

Cancer

132

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“…Its histological diagnosis is controversial: it is accepted by some authors [3,4,6,14] and rejected by others [11,12], The WHO has accepted its morphological autonomy among the skin cancers [ 18]. The relative radioresis tance [19] and the tendency to relapses and métastasés [3,7,17] are biological features which distinguish the basosquamous carcino ma from the basal cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Basosquamous Carcinoma of the Orbit Invading the Maxillary Sinus (With 1 color plate)

Catalano

Cavallaro²,

Gangemi³

et al. 1988

Ophthalmologica

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“…[5][6][7][8][9] These carcinomas are not more aggressive. That is, they are not more likely to metastasize or invade muscle, nerve, or vasculature.…”

Section: Indicationsmentioning

confidence: 98%

Peripheral Frozen Sections

Davis¹,

Pellowski²

2005

Pathology Case Reviews

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Skin cancer cure rates of 99% can be promised to the patient if the entire peripheral margin of a cutaneous excision is verified to be free of that cancer. Preparing frozen sections to examine only the peripheral margin may seem esoteric to the surgical pathologist. This technique was historically named Mohs' micrographic surgery and is typically performed by a dermatologist in an outpatient clinic, away from the observation of other medical specialists. This treatise provides detailed specifics on how to prepare tissue for peripheral margin evaluation. Along the way, it also provides a brief history of Frederic Mohs' discoveries of the 1930s and how several generations of skin cancer surgeons have refined Mohs' techniques to offer the cutting-edge advantages of the highest cure rates and normal skin sparing.

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Differentiation in the Rodent Ulcer Group of Tumours

Abstract: Images Figs. 8-11 Figs. 12-14 Figs. 1-3 Figs. 4-7

Cited by 34 publications

References 2 publications

Basosquamous carcinoma

Basosquamous carcinoma

A Rare Case of Basosquamous Carcinoma of the Orbit Invading the Maxillary Sinus (With 1 color plate)

Peripheral Frozen Sections

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