The Value of Glucagon in Routine Barium Investigations of the Gastrointestinal Tract

Rothe, A.; Young, Jeremy W. R.; Keramati, B

doi:10.1097/00004424-198710000-00004

Cited by 9 publications

(7 citation statements)

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“…The advantage of glucagon, as compared to anticholinergic agents, is that it is virtually free of side effects at the low doses used in radiology. However, some radiologists do not agree with the routine use of glucagon in gastrointestinal radiology because of the pain and discomfort related to intravenous injection, the high cost of the hormone, and the necessity to keep the drug stocked [23,24].…”

Section: Discussionmentioning

confidence: 99%

“…Intravenous (IV) glucagon (commercially available porcine glucagon, Novo, Bagsvaerd [23], Denmark), 0.5 mg, was prepared fresh before administration following manufacturer's instructions. Intranasal (IN) glucagon was prepared as follows: 1 mg lyophilized glucagon and sodium glycocholate (SGC, Calbiochem-Behring, La Jolla, CA, USA) were stored together as powder in a capsule that was placed on top of a brown glass bottle (Koster, Milan, Italy) that contained a diluent (0.7 ml).…”

Section: Methodsmentioning

confidence: 99%

“…Motility was evaluated by a 1-4 semiquantitative score in which 1 = paradoxical hypermotility; 2 = normal motility; 3 = poor motility; and 4 = immotility [23].…”

Section: Gastric Motility Score Of Efficacymentioning

confidence: 99%

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The hypotonic effect of intranasal and intravenous glucagon in gastrointestinal radiology

et al. 1995

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In the present study, following a double-blind, double placebo protocol vs. placebo, we compared the hypotonic effect of intranasal and intravenous glucagon during a double-contrast barium meal examination of the stomach. We found a statistically significant difference between placebo and intranasal or intravenous glucagon in inducing gastric hypomotility, with no significant differences between IN and IV glucagon. The intranasal administration of glucagon has the advantage of being noninvasive and well tolerated by the patients, and might be a valuable aid in upper gastrointestinal examination as well as in CT scan or magnetic resonance imaging of the abdomen.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The hypotonic effect of intranasal and intravenous glucagon in gastrointestinal radiology

et al. 1995

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“…Hypotonization of the stomach and duodenum, recommended in pre-eminent textbooks of gastrointestinal radiology [2±3], is accepted with few exceptions [4]. The two most used hypotonic agents are glucagon and hyoscine-N-butylbromide (HBB), with preference for the former or the latter by the various authors.…”

Section: Introductionmentioning

confidence: 99%

Compared effect of a genetically engineered glucagon and hyoscine N-butylbromide on double-contrast barium meal study

et al. 1998

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The aim of this study was to compare the effects of a genetically engineered glucagon (geG) and hyoscine N-butylbromide (HBB) on the quality of double-contrast barium meal (DCBM) study. Two hundred sixty-four patients scheduled for DCBM were randomized to receive intravenously geG 0.25 mg (geG-25), or geG 0.5 mg (geG-50), or HBB 20 mg as hypotonic agent. The evaluation concerned: duration of isolated visualization of the stomach (A); gastric mucosal coating (B); visualization of areae gastricae (C); quality of duodenal cap (D) and loop (E) study; delay, if any, of duodenal study (F). Global significant differences (P from 0.0183 to < 0.0001) were found for A, C, D, and F. GeG-50 allowed the longest isolated gastric visualization (P < 0.0001); geG-25 allowed more extensive visualization of areae gastricae than HBB (P = 0.0006); HBB allowed a better study of duodenal cap (P = 0.0052) and loop (P = 0.0190) than geG-25; geG-50 prolonged the examination time (P < 0.01). No adverse effect was observed with geG within 1 h after DCBM. In conclusion, geG can be safely used as a hypotonic agent in DCBM. When DCBM is focused on the stomach, 0.25 mg of geG is the optimal choice; if DCBM is focused on the duodenum, 0.5 mg of geG (with a prolonged examination time) or 20 mg of HBB (with a less effective study of the stomach) should be used.

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“…It has previously been suggested as an aid in barium enema procedures,24 based on a small number of RCTs. Although glucagon decreases pain,25 it shows no advantages over placebo in term of colon distension or exam quality 26 27. However, it has been used by some physicians treating infants with acute intestinal intussusception.…”

Section: Commentarymentioning

confidence: 99%

Question 3 Does the administration of glucagon improve the rate of radiological reduction in children with acute intestinal intussusception?: Table 3

Cachat¹,

Ramseyer²

2012

Arch Dis Child

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The Value of Glucagon in Routine Barium Investigations of the Gastrointestinal Tract

Cited by 9 publications

References 0 publications

The hypotonic effect of intranasal and intravenous glucagon in gastrointestinal radiology

The hypotonic effect of intranasal and intravenous glucagon in gastrointestinal radiology

Compared effect of a genetically engineered glucagon and hyoscine N-butylbromide on double-contrast barium meal study

Question 3 Does the administration of glucagon improve the rate of radiological reduction in children with acute intestinal intussusception?: Table 3

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