Question 3 Does the administration of glucagon improve the rate of radiological reduction in children with acute intestinal intussusception?: Table 3

Cachat, François; Ramseyer, Pascal

doi:10.1136/archdischild-2012-301763

Cited by 4 publications

(4 citation statements)

References 28 publications

(19 reference statements)

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“…adjuvants can facilitate non-surgical management, but their e icacy remains controversial. For example, glucagon is an antispasmodic adjuvant used by 10% to 21% of surveyed practitioners (Cachat 2012;Katz 1992;Meyer 1992;Rosenfeld 1999). It provides analgesia (Lappas 1995) and reduces colonic muscle tone (Skucas 1994).…”

Section: Pharmacologicalmentioning

confidence: 99%

“…It provides analgesia (Lappas 1995) and reduces colonic muscle tone (Skucas 1994). However, a recent narrative review suggests that glucagon does not improve the rate of reduction in the non-surgical management of intussusception (Cachat 2012). Other adjuvants include antibiotics (Ein 2006;Moss 2000;Pepper 2012).…”

Section: Pharmacologicalmentioning

confidence: 99%

“…To the best of our knowledge, this is the only systematic review of RCTs related to this topic, including unpublished data and ongoing trials. However, several narrative reviews have included comparative studies and RCTs (Applegate 2009;Cachat 2012;Daneman 2003;Ko 2007;Sadigh 2015). Applegate 2009 included comparative trials as well as RCTs to examine the role of ultrasonography, air versus liquid enema for reduction, and risk of bowel perforation in children with intussusception.…”

Section: Agreements and Disagreements With Other Studies Or Reviewsmentioning

confidence: 99%

“…These results are similar to those of the current review. Applegate 2009, Cachat 2012, Daneman 2003, Ko 2007, and Sadigh 2015 included no relevant randomised trial that was not included in our review.…”

Section: Agreements and Disagreements With Other Studies Or Reviewsmentioning

confidence: 99%

See 3 more Smart Citations

Management for intussusception in children

Gluckman

Karpelowsky

Webster

et al. 2017

Cochrane Database of Systematic Reviews

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This review identified a small number of trials that assessed a variety of interventions. All included trials provided evidence of low quality and were subject to serious concerns about imprecision, high risk of bias, or both. Air enema may be superior to liquid enema for successfully reducing intussusception in children; however, this finding is based on a few studies including small numbers of participants. Dexamethasone as an adjuvant may be more effective in reducing intussusception recurrence rates following air enema or liquid enema, but these results are also based on a few studies of small numbers of participants. This review highlights several points that need to be addressed in future studies, including reducing the risk of bias and including relevant outcomes. Specifically, surgical trials are lacking, and future research is needed to address this evidence gap.

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Section: Pharmacologicalmentioning

confidence: 99%

Section: Pharmacologicalmentioning

confidence: 99%