The value of global longitudinal strain and galectin-3 for predicting cardiovascular events in patients with severe aortic stenosis

Agoşton-Coldea, Lucia; Bheecarry, Kunal; Petra, Cristian; Strambu, Lelia; Ober, Camelia; Revnic, Radu; Lupu, Silvia; Mocan, Teodora; Fodor, Daniela

doi:10.11152/mu-1456

Cited by 8 publications

(10 citation statements)

References 26 publications

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“…This significance only remained after multivariate adjustment in one study [75], with the significance abolished after adjustment for age [66], eGFR [76] and STS score [43] in the other studies. In the one study that reported MACE, Galectin-3 was found to be significantly associated with MACE; however, this did not remain on adjustment for confounding factors [59].…”

Section: Galectin-3mentioning

confidence: 83%

“…The average age of participants was 79 years and 57% were male (Supplementary Material, Table S5). All studies reported all-cause mortality excluding one which exclusively reported MACE [59]. Galectin-3 was found to be significantly associated with all-cause mortality in all that reported it, with an average two-fold increased risk of death in those with higher baseline levels of Galectin-3 [43,66,75,76].…”

Section: Galectin-3mentioning

confidence: 97%

“…Importantly, only one study found that BNP was not significantly associated with all-cause mortality [26]. Similarly, 23 of the NT-proBNP studies reported all-cause mortality [6,17,22,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] and the other 10 studies reported composite mortality outcomes such as MACE [59][60][61][62][63][64][65][66][67][68]. Again, only one study found that NT-proBNP was not significantly associated with all-cause mortality [52].…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

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Biomarkers Associated with Mortality in Aortic Stenosis: A Systematic Review and Meta-Analysis

et al. 2021

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The optimal timing of aortic valve replacement (AVR) remains controversial. Several biomarkers reflect the underlying pathophysiological processes in aortic stenosis (AS) and may be of use as mortality predictors. The aim of this systematic review and meta-analysis is to evaluate the blood biomarkers utilised in AS and assess whether they associate with mortality. PubMed and Embase were searched for studies reporting baseline biomarker level and mortality outcomes in patients with AS. A total of 83 studies met the inclusion criteria and were systematically reviewed. Of these, 21 reporting brain natriuretic peptide (BNP), N-terminal pro B-type natriuretic peptide (NT-proBNP), Troponin and Galectin-3 were meta-analysed. Pooled analysis demonstrated that all-cause mortality was significantly associated with elevated baseline levels of BNP (HR 2.59; 95% CI 1.95–3.44; p < 0.00001), NT-proBNP (HR 1.73; 95% CI 1.45–2.06; p = 0.00001), Troponin (HR 1.65; 95% CI 1.31–2.07; p < 0.0001) and Galectin-3 (HR 1.82; 95% CI 1.27–2.61; p < 0.001) compared to lower baseline biomarker levels. Elevated levels of baseline BNP, NT-proBNP, Troponin and Galectin-3 were associated with increased all-cause mortality in a population of patients with AS. Therefore, a change in biomarker level could be considered to refine optimal timing of intervention. The results of this meta-analysis highlight the importance of biomarkers in risk stratification of AS, regardless of symptom status.

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Section: Galectin-3mentioning

confidence: 83%

Section: Galectin-3mentioning

confidence: 97%

Section: Natriuretic Peptidesmentioning

confidence: 99%

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Biomarkers Associated with Mortality in Aortic Stenosis: A Systematic Review and Meta-Analysis

et al. 2021

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“…Ventricular interdependence is the mechanism through which the size, shape, compliance, and pressure-volume curve of one ventricle can affect those of the other ventricle [1,2]. The main anatomical structures that enable ventricular interactions are the interventricular septum, pericardium, myocardial muscular fibers, which connect the two ventricles, and pulmonary vascular system [3,4]. The myocardial fibers of the right ventricle resemble a web composed of three layers and the main muscular components reside in the superficial and deep layers.…”

mentioning

confidence: 99%

“…* email: alina_paunescu@yahoo.com; Phone: 0745135095 Pulmonary vascularization is one form of connection between the ventricles. Changes in the relaxation and/or contraction properties of the left ventricle lead to changes in the after-load of the right ventricle, with a subsequent impact on the function of the right ventricle [4]. Ventricular interdependence occurs continuously and is prominent in both postural and respiratory conditions.…”

mentioning

confidence: 99%

The Significance of Ventricular Interdependence in Patients with Right Ventricular Hypertrophy and Normal Left Ventricular Function

Paun¹,

Nanea²,

Nicolae³

et al. 2019

Rev. Chim.

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The aim of the study is to quantify ventricular interactions by comparing tissue and spectral systolic echocardiographic parameters to allow the early identification of ventricular dysfunction. Clinical, paraclinical, electrocardiographic and echocardiographic evaluations were performed. Right ventricular hypertrophy was diagnosed in the M mode subcostal echocardiographic section. RV hypertrophy was defined by a right ventricular free wall thickness of ] 5 mm in diastole. We assessed the following RV and LV tissue and spectral systolic indices: apical systolic excursion of the lateral mitral ring (MAPSE), apical systolic excursion of the lateral tricuspid ring (TAPSE), left (Svs) and right (Svd) ventricular tissue systolic velocities, and RV and LV ejection times. We calculated the following to assess systolic ventricular interdependence: MAPSE/TAPSE, the normal value of which was considered as 0.66 � 0.14, and Svs/Svd, the normal value of which was considered as 0.76 � 0.21. The study group was compared to a control group with the same clinical features but without ventricular hypertrophy. Twenty-one patients were included in the study: 13 men (62%) and eight women (38%) with a mean age of 56 � 3.8 years. We compared the values between the study group and control group, with the following results: TAPSE = 20.4 � 0.9 vs. 24.1 � 0.76 and MAPSE/TAPSE = 0.74 � 0.06 vs. 0.75 � 0.04. MAPSE was comparable between the groups. Svs was comparable between the groups (0.09 � 0.01 vs. 0.12 � 0.02), whereas Svd was different between the groups (0.11 � 0.03 vs 0.16 � 0.03). Svs/Svd was 0.81 � 0.05 in the study group and 0.75 � 0.08 in the control group. LV ejection time was comparable between the two groups (299.8 � 23.6 ms vs. 303.3 � 28 ms), whereas, RV ejection time differed between the groups (275 � 17 ms vs. 245.5 � 28.5). Changes in TAPSE and MAPSE/TAPSE, in addition to Svd and Svs/Svd, are related to right ventricular dysfunction and suggest pathological changes in the interdependence mechanism of the ventricles in patients with RV hypertrophy. In addition, RV free wall thickness was strongly correlated with ventricular interdependence parameters, with the exception of MAPSE. Assessing these parameters and proportions in clinical practice will facilitate the early detection and appropriate treatment of right ventricular dysfunction.

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Non-ischemic dilated cardiomyopathy and cardiac fibrosis

2020

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The value of global longitudinal strain and galectin-3 for predicting cardiovascular events in patients with severe aortic stenosis

Abstract: Among tested parameters, GLS and NT-proBNP were the most reliable predictors of MACEs in patients with severe AS, while Galectin-3 performed more poorly.

Cited by 8 publications

References 26 publications

Biomarkers Associated with Mortality in Aortic Stenosis: A Systematic Review and Meta-Analysis

Biomarkers Associated with Mortality in Aortic Stenosis: A Systematic Review and Meta-Analysis

The Significance of Ventricular Interdependence in Patients with Right Ventricular Hypertrophy and Normal Left Ventricular Function

Non-ischemic dilated cardiomyopathy and cardiac fibrosis

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