The Value of Apparent Diffusion Coefficient Measurement in Assessment and Follow Up of Multiple Sclerosis Patients

Ragheb, Samar Ramzy; Ekladious, Mena E.Y.

doi:10.21608/ejhm.2021.150438

Cited by 2 publications

(2 citation statements)

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“…However, some case series documented that some asymptomatic MS patients may diagnosed by chance during the MRI examination indicated for other diseases other than suspected inflammatory demyelinating disease of CNS, in these cases the situation referred as radiologically isolated syndrome as a common type of MS. 19 The present study comparison of MRI ADC of M.S plaques in symptomatic and asymptomatic group revealed that mean ADC value in symptomatic group was significantly higher than that in asymptomatic group; 1.43±0.21 vs. 1.18±0.19 x (10 −3 mm 2 /s), respectively, (P<0.001). This finding indicated an association between disease activity and ADC values and consistent with that reported in previous studies 20,21,22 Additionally, ADC value were not significantly different between restricted plaques on DWI in symptomatic and asymptomatic MS patients (37). Also no significant differences were found in the number of plaques that enhanced or not despite that, T1post contrast enhancement of M.S plaques was more detected in the symptomatic than asymptomatic patient as well as the restricted plaques were more in symptomatic than in asymptomatic patients but not reach significant level.…”

Section: Adc Value X (10supporting

confidence: 91%

“…Another study conducted by Almolla et al 23 , documented that ADC was significantly correlated to cognitive impairment in MS patients with relapse remittent form with regard to the plaque number, periplaque and normal white matter. A recent Egyptian study conducted by Ragheb et al 22 found that ADC value of normal white matter and MS can be used to differentiate MS and assessment of clinical subtypes and also can be helpful in follow up of progression of disease as it showed strong correlation with the degree of progression. Furthermore, Ragheb et al 22 also assessed the value of ADC in differentiation between relapsing remittent from progressive cases and found that at cutoff point of 1.3 x10 -3 mm 2 /sec ADC had a sensitivity of 89.3%, specificity of 85% and accuracy of 80%, which are close to our results.…”

Section: Adc Value X (10mentioning

confidence: 99%

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Role of Diffusion Weighted Imaging and Apparent Diffusion Coefficient Value in Diagnosis of Asymptomatic / Inactive Multiple Sclerosis Plaques

Al-Isawi

Keshn²,

Roshdy³

2022

Al-Azhar International Medical Journal

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Background: Although in most cases, the diagnosis of MS remains a clinical, magnetic resonance imaging became a fundamental imaging technique for the investigation and monitoring patients with MS, as it allows the visualization of lesions in the brain and spinal cord and help in understanding and follow of the disease and it is widely used to confirm the clinical diagnosis. Aim of TheWork: To evaluation of asymptomatic or inactive multiple sclerosis plaques by using diffusion weighted imaging and ADC value. Patients and Methods: We evaluated prospectively 50 patients with known multiple sclerosis and fulfilled McDonald Criteria 2017. Patients of interest were recruited from the Neurology department in Al-Azhar University Hospitals during two years (May 2020 to May 2022). Clinical diagnosis was performed by an expert neurologist with 10 years of experience in treating MS.Results: Receiver operator characteristics (ROC) curves for ADC value x (10−3 mm2/s) as a predictor of activity of the M.S disease in enrolled patients. ADC value x (10−3 mm2/s) indices were significant predictors as denoted by the significantly large area under the curves (AUCs), there was used to define the best cut off value of ADC value x (10−3 mm2/s) which was ≥1.292, with sensitivity of 82.1% specificity of 82.6% positive predictive value of 85.2%, negative predictive value of 79.2%, diagnostic area under the curve of 0.828 with p-value <0.001. Conclusion: Measurement of ADC value should be done as a routine study with conventional MRI in MS patients.

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Section: Adc Value X (10supporting

confidence: 91%

Section: Adc Value X (10mentioning

confidence: 99%

Role of Diffusion Weighted Imaging and Apparent Diffusion Coefficient Value in Diagnosis of Asymptomatic / Inactive Multiple Sclerosis Plaques

Al-Isawi

Keshn²,

Roshdy³

2022

Al-Azhar International Medical Journal

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Apparent Diffusion Coefficient in the Diagnosis and Follow-up of Multiple Sclerosis: Role of Magnetic Resonance Imaging

Ahmed,

Dema,

Yehia

et al. 2024

Al-Rafidain J Med Sci

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Background: Chronic Multiple Sclerosis (MS) modifies the apparent diffusion coefficient (ADC) value due to severe pathological changes. After trauma, it is the second most common cause of brain injury in healthy young adults. MRI is considered the initial imaging modality for MS diagnosis and follow-up. Objective: To assess the significance of the ADC in the diagnosis and follow-up of MS plaques across various disease subtypes. Methods: Forty MS patients were included in a case-control study at Ibn-Sina Teaching Hospital, Mosul Province, between June 1, 2022 and February 28, 2023. The patients had diffusion-weighted and traditional MR imaging with ADC measurement in plaques, and the normal white matter value of controls was compared to the patients' results. Results: The ADC values were higher in cases that were acute or secondary-progressive than in relapsing-remitting cases or normal white matter. In both types of newly generated plaques, there was an initial non-significant increase in ADC values compared to existing plaques. Overall, the ADC sensitivity, specificity, and accuracy in diagnosing MS were 85.7%, 95.2%, and 90.5% in acute cases, and 85.7%, 83.3%, and 84.6% in chronic cases, respectively, with no significant difference between active and inactive lesions. Conclusions: The apparent diffusion coefficient value can be included in the imaging protocol for the diagnosis and follow-up of various subtypes of MS.

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The Value of Apparent Diffusion Coefficient Measurement in Assessment and Follow Up of Multiple Sclerosis Patients

Cited by 2 publications

References 13 publications

Role of Diffusion Weighted Imaging and Apparent Diffusion Coefficient Value in Diagnosis of Asymptomatic / Inactive Multiple Sclerosis Plaques

Role of Diffusion Weighted Imaging and Apparent Diffusion Coefficient Value in Diagnosis of Asymptomatic / Inactive Multiple Sclerosis Plaques

Apparent Diffusion Coefficient in the Diagnosis and Follow-up of Multiple Sclerosis: Role of Magnetic Resonance Imaging

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